Selective laser sintering 3D printing of personalized dosage forms : Effect of powder formulation and process parameters on the physical properties of the printed tablets

• Large batches of placebo and drug-loaded solid dosage forms were successfully fabricated using selective laser sintering (SLS) 3D printing. The tablet batches were prepared using pharmaceutical grade Plasdone S-360 (60:40 linear copolymer of N-vinyl-2-pyrrolidone and vinyl acetate) and activated carbon as the NIR-active pigment, which was added to improve the sintering of the polymer. The physical properties of the tablets were evaluated at different pigment concentrations (i.e. 0.5 and 1.0 wt.%) and at different laser energy inputs (LPR). The mass, hardness, and friability of the tablets were found to be tunable and structures of higher mass and mechanical strength were obtained with increasing carbon concentration and LPR. Amorphization of the active pharmaceutical ingredient in the drug-loaded batches, which contained 10 wt.% naproxen and 1 wt.% activated carbon, was achieved in-situ during printing and the obtained tablets showed friabilities below 1 wt.%. In conclusion, this study has shown that solid dosage forms of varying mass and mechanical strength can be manufactured using SLS 3D printing. The preparation of amorphous solid dispersions could further be prepared in a single step during the printing process thus making SLS 3D printing an interesting and promising technique for the fabrication of personalized medicines.

Ämnesord

TEKNIK OCH TEKNOLOGIER  -- Nanoteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Nano-technology (hsv//eng)

Nyckelord

additive manufacturing

3D printing

selective laser sintering

personalized medicines

Teknisk fysik med inriktning mot nanoteknologi och funktionella material

Engineering Science with specialization in Nanotechnology and Functional Materials

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