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Adenoviral CD40 Lig...
Adenoviral CD40 Ligand Immunotherapy in 32 Canine Malignant Melanomas-Long-Term Follow Up
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- Saellström, Sara (författare)
- Uppsala universitet,Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,University Animal Hospital,Swedish Univ Agr Sci SLU, Univ Anim Hosp, Uppsala, Sweden.,Klinisk immunologi
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- Sadeghi, Arian, 1977- (författare)
- Uppsala universitet,Klinisk immunologi
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- Eriksson, Emma (författare)
- Uppsala universitet,Klinisk immunologi
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- Segall, Thomas (författare)
- Natl Vet Inst, Dept Pathol & Wildlife Dis, Uppsala, Sweden.
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- Dimopoulou, Maria (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,University Animal Hospital,Swedish Univ Agr Sci SLU, Univ Anim Hosp, Uppsala, Sweden.
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- Korsgren, Olle (författare)
- Uppsala universitet,Klinisk immunologi
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- Loskog, Angelica S.I. 1973- (författare)
- Uppsala universitet,Klinisk immunologi
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- Tötterman, Thomas (författare)
- Uppsala universitet,Klinisk immunologi
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- Hemminki, Akseli (författare)
- Univ Helsinki, Translat Immunol Res Program, Canc Gene Therapy Grp, Helsinki, Finland.;Helsinki Univ Hosp, Ctr Comprehens Canc, Helsinki, Finland.
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- Rönnberg, Henrik (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Swedish Univ Agr Sci SLU, Fac Vet Med & Anim Sci, Dept Clin Sci, Ctr Clin Comparat Oncol C3O, Uppsala, Sweden.
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- 2021-07-23
- 2021
- Engelska.
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Ingår i: Frontiers in Veterinary Science. - : Frontiers Media S.A.. - 2297-1769. ; 8
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.frontier...
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https://pub.epsilon.... (primary) (Raw object) (free)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://res.slu.se/i...
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Abstract
Ämnesord
Stäng
- Malignant melanoma is a serious disease in both humans and dogs, and the high metastatic potential results in poor prognosis for many patients. Its similarities with human melanoma make spontaneous canine melanoma an excellent model for comparative studies of novel therapies and tumor biology. Gene therapy using adenoviruses encoding the immunostimulatory gene CD40L (AdCD40L) has shown promise in initial clinical trials enrolling human patients with various malignancies including melanoma. We report a study of local AdCD40L treatment in 32 cases of canine melanoma (23 oral, 5 cutaneous, 3 ungual and 1 conjunctival). Eight patients were World Health Organization (WHO) stage I, 9 were stage II, 12 stage III, and 3 stage IV. One to six intratumoral injections of AdCD40L were given every seven days, combined with cytoreductive surgery in 20 cases and only immunotherapy in 12 cases. Tumor tissue was infiltrated with T and B lymphocytes after treatment, suggesting immune stimulation. The best overall response based on result of immunotherapy included 7 complete responses, 5 partial responses, 5 stable and 2 progressive disease statuses according to the World Health Organization response criteria. Median survival was 285 days (range 20-3435 d). Our results suggest that local AdCD40L therapy is safe and could have beneficial effects in dogs, supporting further treatment development. Clinical translation to human patients is ongoing.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Klinisk vetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Clinical Science (hsv//eng)
Nyckelord
- immuno oncology
- adenoviral vectors
- translational medicine
- canine malignant melanoma
- clinical trials
- AdCD40L
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- ref (ämneskategori)
- art (ämneskategori)
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Saellström, Sara
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Sadeghi, Arian, ...
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Eriksson, Emma
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Segall, Thomas
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Dimopoulou, Mari ...
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Korsgren, Olle
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visa fler...
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Loskog, Angelica ...
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Tötterman, Thoma ...
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Hemminki, Akseli
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Rönnberg, Henrik
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Uppsala universitet
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