NT-proBNP for Risk Prediction in Heart Failure: Identification of Optimal Cutoffs Across Body Mass Index Categories

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Januzzi James L) > NT-proBNP for Risk ...

22 of 22
Previous record
Next record
To hitlist

NT-proBNP for Risk Prediction in Heart Failure : Identification of Optimal Cutoffs Across Body Mass Index Categories

Vergaro, Giuseppe (author): Scuola Super Sant Anna, Pisa, Italy; Fdn Toscana G Monasterio, Pisa, Italy

Gentile, Francesco (author): Fdn Toscana G Monasterio, Pisa, Italy

Meems, Laura M. G. (author): Univ Med Ctr Groningen, Groningen, Netherlands

Aimo, Alberto (author): Scuola Super Sant Anna, Pisa, Italy

Januzzi Jr., James L. (author): Massachusetts Gen Hosp, Boston, MA 02114 USA; Baim Inst Clin Res, Boston, MA USA

Richards, A. Mark (author): Univ Otago, Dunedin, New Zealand

Lam, Carolyn S. P. (author): Natl Heart Ctr Singapore, Singapore, Singapore; Duke Natl Univ Singapore, Singapore, Singapore

Latini, Roberto (author): IRCCS Milano, IRCCS Ist Ric Farmacol Mario Negri, Milan, Italy

Staszewsky, Lidia (author): IRCCS Milano, IRCCS Ist Ric Farmacol Mario Negri, Milan, Italy

Anand, Inder S. (author): Univ Minnesota, Minneapolis, MN USA; VA Med Ctr, Minneapolis, MN USA

Cohn, Jay N. (author): Univ Minnesota, Minneapolis, MN USA

Ueland, Thor (author): Oslo Univ Hosp, Oslo, Norway; Oslo Univ Hosp, Rigshosp, Oslo, Norway; Univ Oslo, Oslo, Norway; Univ Tromso, Tromso, Norway

Gullestad, Lars (author): Univ Oslo, KG Jebsen Ctr Cardiac Res, Oslo, Norway; Oslo Univ Hosp, Ctr Heart Failure Res, Oslo, Norway

Aukrust, Pål (author): Oslo Univ Hosp, Rigshosp, Oslo, Norway; Univ Oslo, Oslo, Norway

Brunner-La Rocca, Hans-Peter (author): Maastricht Univ, Med Ctr, Maastricht, Netherlands

Bayes-Genis, Antoni (author): Hosp Badalona Germans Trias & Pujol, Badalona, Barcelona, Spain; Inst Salud Carlos III, CIBER Cardiovasc, Madrid, Spain

Lupón, Josep (author): Hosp Badalona Germans Trias & Pujol, Badalona, Barcelona, Spain; Inst Salud Carlos III, CIBER Cardiovasc, Madrid, Spain

Yoshihisa, Akiomi (author): Fukushima Med Univ, Fukushima, Japan

Takeishi, Yasuchika (author): Fukushima Med Univ, Fukushima, Japan

Egstrup, Michael (author): Copenhagen Univ Hosp, Rigshosp, Copenhagen, Denmark

Gustafsson, Ida (author): Copenhagen Univ Hosp, Rigshosp, Copenhagen, Denmark

Gaggin, Hanna K. (author): Massachusetts Gen Hosp, Boston, MA 02114 USA; Harvard Med Sch, Boston, MA 02115 USA

Eggers, Kai M., 1962- (author): Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi

Huber, Kurt (author): Wilhelminenspital Stadt Wien, Vienna, Austria; Sigmund Freud Univ, Med Sch, Vienna, Austria

Gamble, Greg D. (author): Univ Auckland, Auckland, New Zealand

Ling, Lieng H. (author): Natl Univ Heart Ctr, Singapore, Singapore; Natl Univ Singapore, Singapore, Singapore

Leong, Kui Tong Gerard (author): Changi Gen Hosp, Singapore, Singapore

Yeo, Poh Shuah Daniel (author): Tan Tock Seng Hosp, Singapore, Singapore

Ong, Hean Yee (author): Khoo Teck Puat Hosp, Singapore, Singapore

Jaufeerally, Fazlur (author): Singapore Gen Hosp, Singapore, Singapore

Ng, Tze P. (author): Natl Univ Heart Ctr, Singapore, Singapore; Natl Univ Singapore, Singapore, Singapore

Troughton, Richard (author): Massachusetts Gen Hosp, Boston, MA 02114 USA; Baim Inst Clin Res, Boston, MA USA

Doughty, Robert N. (author): Univ Auckland, Auckland, New Zealand

Devlin, Gerry (author): Gisborne Hosp, Gisborne, New Zealand

Lund, Mayanna (author): Middlemore Hosp, Auckland, New Zealand

Giannoni, Alberto (author): Scuola Super Sant Anna, Pisa, Italy; Fdn Toscana G Monasterio, Pisa, Italy

Passino, Claudio (author): Scuola Super Sant Anna, Pisa, Italy; Fdn Toscana G Monasterio, Pisa, Italy

Boer, Rudolf A. de (author): Univ Med Ctr Groningen, Groningen, Netherlands

Emdin, Michele (author): Scuola Super Sant Anna, Pisa, Italy; Fdn Toscana G Monasterio, Pisa, Italy

show less...

(creator_code:org_t)

American College of Cardiology, 2021
2021
English.
In: JACC. Heart failure. - : American College of Cardiology. - 2213-1779 .- 2213-1787. ; 9:9, s. 653-663

Related links:: https://pure.rug.nl/...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

ObjectivesThe goal of this study was to assess the predictive power of N-terminal pro–B-type natriuretic peptide (NT-proBNP) and the decision cutoffs in heart failure (HF) across body mass index (BMI) categories.BackgroundConcentrations of NT-proBNP predict outcome in HF. Although the influence of BMI to reduce levels of NT-proBNP is known, the impact of obesity on prognostic value remains uncertain.MethodsIndividual data from the BIOS (Biomarkers In Heart Failure Outpatient Study) consortium were analyzed. Patients with stable HF were classified as underweight (BMI <18.5 kg/m2), normal weight (BMI 18.5-24.9 kg/m2), overweight (BMI 25-29.9 kg/m2), and mildly (BMI 30-34.9 kg/m2), moderately (BMI 35-39.9 kg/m2), or severely (BMI ≥40 kg/m2) obese. The prognostic role of NT-proBNP was tested for the endpoints of all-cause and cardiac death.ResultsThe study population included 12,763 patients (mean age 66 ± 12 years; 25% women; mean left ventricular ejection fraction 33% ± 13%). Most patients were overweight (n = 5,176), followed by normal weight (n = 4,299), mildly obese (n = 2,157), moderately obese (n = 612), severely obese (n = 314), and underweight (n = 205). NT-proBNP inversely correlated with BMI (β = –0.174 for 1 kg/m2; P < 0.001). Adding NT-proBNP to clinical models improved risk prediction across BMI categories, with the exception of severely obese patients. The best cutoffs of NT-proBNP for 5-year all-cause death prediction were lower as BMI increased (3,785 ng/L, 2,193 ng/L, 1,554 ng/L, 1,045 ng/L, 755 ng/L, and 879 ng/L, for underweight, normal weight, overweight, and mildly, moderately, and severely obese patients, respectively) and were higher in women than in men.ConclusionsNT-proBNP maintains its independent prognostic value up to 40 kg/m2 BMI, and lower optimal risk-prediction cutoffs are observed in overweight and obese patients.

Find in a library

JACC. Heart failure (Search for host publication in LIBRIS)

To the university's database

22 of 22
Previous record
Next record
To hitlist

Find more in SwePub

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

Articles in the publication: JACC. Heart fail ...

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

NT-proBNP for Risk Prediction in Heart Failure : Identification of Optimal Cutoffs Across Body Mass Index Categories

Subject headings

Keyword

Publication and Content Type

Find in a library

To the university's database

Find more in SwePub

Search outside SwePub