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NT-proBNP for Risk ...
NT-proBNP for Risk Prediction in Heart Failure : Identification of Optimal Cutoffs Across Body Mass Index Categories
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- Vergaro, Giuseppe (författare)
- Scuola Super Sant Anna, Pisa, Italy; Fdn Toscana G Monasterio, Pisa, Italy
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- Gentile, Francesco (författare)
- Fdn Toscana G Monasterio, Pisa, Italy
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- Meems, Laura M. G. (författare)
- Univ Med Ctr Groningen, Groningen, Netherlands
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- Aimo, Alberto (författare)
- Scuola Super Sant Anna, Pisa, Italy
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- Januzzi Jr., James L. (författare)
- Massachusetts Gen Hosp, Boston, MA 02114 USA; Baim Inst Clin Res, Boston, MA USA
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- Richards, A. Mark (författare)
- Univ Otago, Dunedin, New Zealand
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- Lam, Carolyn S. P. (författare)
- Natl Heart Ctr Singapore, Singapore, Singapore; Duke Natl Univ Singapore, Singapore, Singapore
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- Latini, Roberto (författare)
- IRCCS Milano, IRCCS Ist Ric Farmacol Mario Negri, Milan, Italy
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- Staszewsky, Lidia (författare)
- IRCCS Milano, IRCCS Ist Ric Farmacol Mario Negri, Milan, Italy
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- Anand, Inder S. (författare)
- Univ Minnesota, Minneapolis, MN USA; VA Med Ctr, Minneapolis, MN USA
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- Cohn, Jay N. (författare)
- Univ Minnesota, Minneapolis, MN USA
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- Ueland, Thor (författare)
- Oslo Univ Hosp, Oslo, Norway; Oslo Univ Hosp, Rigshosp, Oslo, Norway; Univ Oslo, Oslo, Norway; Univ Tromso, Tromso, Norway
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- Gullestad, Lars (författare)
- Univ Oslo, KG Jebsen Ctr Cardiac Res, Oslo, Norway; Oslo Univ Hosp, Ctr Heart Failure Res, Oslo, Norway
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- Aukrust, Pål (författare)
- Oslo Univ Hosp, Rigshosp, Oslo, Norway; Univ Oslo, Oslo, Norway
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- Brunner-La Rocca, Hans-Peter (författare)
- Maastricht Univ, Med Ctr, Maastricht, Netherlands
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- Bayes-Genis, Antoni (författare)
- Hosp Badalona Germans Trias & Pujol, Badalona, Barcelona, Spain; Inst Salud Carlos III, CIBER Cardiovasc, Madrid, Spain
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- Lupón, Josep (författare)
- Hosp Badalona Germans Trias & Pujol, Badalona, Barcelona, Spain; Inst Salud Carlos III, CIBER Cardiovasc, Madrid, Spain
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- Yoshihisa, Akiomi (författare)
- Fukushima Med Univ, Fukushima, Japan
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- Takeishi, Yasuchika (författare)
- Fukushima Med Univ, Fukushima, Japan
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- Egstrup, Michael (författare)
- Copenhagen Univ Hosp, Rigshosp, Copenhagen, Denmark
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- Gustafsson, Ida (författare)
- Copenhagen Univ Hosp, Rigshosp, Copenhagen, Denmark
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- Gaggin, Hanna K. (författare)
- Massachusetts Gen Hosp, Boston, MA 02114 USA; Harvard Med Sch, Boston, MA 02115 USA
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- Eggers, Kai M., 1962- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Huber, Kurt (författare)
- Wilhelminenspital Stadt Wien, Vienna, Austria; Sigmund Freud Univ, Med Sch, Vienna, Austria
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- Gamble, Greg D. (författare)
- Univ Auckland, Auckland, New Zealand
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- Ling, Lieng H. (författare)
- Natl Univ Heart Ctr, Singapore, Singapore; Natl Univ Singapore, Singapore, Singapore
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- Leong, Kui Tong Gerard (författare)
- Changi Gen Hosp, Singapore, Singapore
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- Yeo, Poh Shuah Daniel (författare)
- Tan Tock Seng Hosp, Singapore, Singapore
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- Ong, Hean Yee (författare)
- Khoo Teck Puat Hosp, Singapore, Singapore
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- Jaufeerally, Fazlur (författare)
- Singapore Gen Hosp, Singapore, Singapore
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- Ng, Tze P. (författare)
- Natl Univ Heart Ctr, Singapore, Singapore; Natl Univ Singapore, Singapore, Singapore
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- Troughton, Richard (författare)
- Massachusetts Gen Hosp, Boston, MA 02114 USA; Baim Inst Clin Res, Boston, MA USA
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- Doughty, Robert N. (författare)
- Univ Auckland, Auckland, New Zealand
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- Devlin, Gerry (författare)
- Gisborne Hosp, Gisborne, New Zealand
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- Lund, Mayanna (författare)
- Middlemore Hosp, Auckland, New Zealand
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- Giannoni, Alberto (författare)
- Scuola Super Sant Anna, Pisa, Italy; Fdn Toscana G Monasterio, Pisa, Italy
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- Passino, Claudio (författare)
- Scuola Super Sant Anna, Pisa, Italy; Fdn Toscana G Monasterio, Pisa, Italy
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- Boer, Rudolf A. de (författare)
- Univ Med Ctr Groningen, Groningen, Netherlands
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- Emdin, Michele (författare)
- Scuola Super Sant Anna, Pisa, Italy; Fdn Toscana G Monasterio, Pisa, Italy
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(creator_code:org_t)
- American College of Cardiology, 2021
- 2021
- Engelska.
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Ingår i: JACC. Heart failure. - : American College of Cardiology. - 2213-1779 .- 2213-1787. ; 9:9, s. 653-663
- Relaterad länk:
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https://pure.rug.nl/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- ObjectivesThe goal of this study was to assess the predictive power of N-terminal pro–B-type natriuretic peptide (NT-proBNP) and the decision cutoffs in heart failure (HF) across body mass index (BMI) categories.BackgroundConcentrations of NT-proBNP predict outcome in HF. Although the influence of BMI to reduce levels of NT-proBNP is known, the impact of obesity on prognostic value remains uncertain.MethodsIndividual data from the BIOS (Biomarkers In Heart Failure Outpatient Study) consortium were analyzed. Patients with stable HF were classified as underweight (BMI <18.5 kg/m2), normal weight (BMI 18.5-24.9 kg/m2), overweight (BMI 25-29.9 kg/m2), and mildly (BMI 30-34.9 kg/m2), moderately (BMI 35-39.9 kg/m2), or severely (BMI ≥40 kg/m2) obese. The prognostic role of NT-proBNP was tested for the endpoints of all-cause and cardiac death.ResultsThe study population included 12,763 patients (mean age 66 ± 12 years; 25% women; mean left ventricular ejection fraction 33% ± 13%). Most patients were overweight (n = 5,176), followed by normal weight (n = 4,299), mildly obese (n = 2,157), moderately obese (n = 612), severely obese (n = 314), and underweight (n = 205). NT-proBNP inversely correlated with BMI (β = –0.174 for 1 kg/m2; P < 0.001). Adding NT-proBNP to clinical models improved risk prediction across BMI categories, with the exception of severely obese patients. The best cutoffs of NT-proBNP for 5-year all-cause death prediction were lower as BMI increased (3,785 ng/L, 2,193 ng/L, 1,554 ng/L, 1,045 ng/L, 755 ng/L, and 879 ng/L, for underweight, normal weight, overweight, and mildly, moderately, and severely obese patients, respectively) and were higher in women than in men.ConclusionsNT-proBNP maintains its independent prognostic value up to 40 kg/m2 BMI, and lower optimal risk-prediction cutoffs are observed in overweight and obese patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- body mass index
- chronic heart failure
- NT-proBNP
- obesity
- outcome
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- Av författaren/redakt...
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Vergaro, Giusepp ...
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Gentile, Frances ...
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Meems, Laura M. ...
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Aimo, Alberto
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Januzzi Jr., Jam ...
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Richards, A. Mar ...
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visa fler...
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Lam, Carolyn S. ...
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Latini, Roberto
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Staszewsky, Lidi ...
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Anand, Inder S.
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Cohn, Jay N.
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Ueland, Thor
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Gullestad, Lars
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Aukrust, Pål
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Brunner-La Rocca ...
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Bayes-Genis, Ant ...
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Lupón, Josep
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Yoshihisa, Akiom ...
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Takeishi, Yasuch ...
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Egstrup, Michael
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Gustafsson, Ida
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Gaggin, Hanna K.
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Eggers, Kai M., ...
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Huber, Kurt
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Gamble, Greg D.
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Ling, Lieng H.
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Leong, Kui Tong ...
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Yeo, Poh Shuah D ...
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Ong, Hean Yee
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Jaufeerally, Faz ...
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Ng, Tze P.
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Troughton, Richa ...
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Doughty, Robert ...
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Devlin, Gerry
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Lund, Mayanna
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Giannoni, Albert ...
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Passino, Claudio
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Boer, Rudolf A. ...
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Emdin, Michele
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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JACC. Heart fail ...
- Av lärosätet
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Uppsala universitet