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Laboratory screenin...
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Rozalem Reali, Ana CarolinaUniv Fed Sao Paulo, Pediat Dept, Escola Paulista Med, Sao Paulo, SP, Brazil.
(author)
Laboratory screening test with inhalant and food allergens in atopic Brazilian children and adolescents : a performance
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-09-01
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CODON PUBLICATIONS,2021
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-456220
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-456220URI
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https://doi.org/10.15586/aei.v49i5.444DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The Phadiatop Infant (R)) is a panel developed to assess allergic sensitization (immunoglobulin E [IgE]) in children aged <5 years and combines inhalant and food allergens. The test has not been evaluated outside Europe. This is a cross-sectional study conducted at 11 pediatric allergy centers to evaluate PhInf as an allergic disease screening method in Brazilian children. Children as controls and patients (aged 6 months-18 years) were grouped according to their primary disease and age group. PhInf and specific serum IgE (sIgE) screening was performed for Dermatophagoides pteronyssinus (DP), cat and dog epithelia, a mix of grasses and pollens, eggs, cow's milk, peanuts, and shrimp. Values >= 0.35 kU (A)/L (or PAU/L) were considered positive. A total of 470 children and adolescents, which included 385 patients and 85 controls, participated in the study (47.7% boys, average age: 6.3 years). In all, 72.6% of the participants had positive PhInf test (n = 341), with a higher proportion of those having food allergy (92.6%), atopic dermatitis (91.9%), and those aged >13 years having allergy (95%). The PhInf and sIgE agreement between patients (Kappa = 0.94, P < 0.001) and controls (Kappa = 0.84, P < 0.001) was high. PhInf and DP agreement in patients aged >13 years was excellent (Kappa = 0.936, P < 0.001). Compared with sIgE dosage, PhInf had high sensitivity (97%) and specificity (93%). Positivity of PhInf test in this population was high and had an excellent correlation with the allergens comprising the panel. It is a useful method for screening children suspected of having allergic diseases in a non-European country.
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Pierotti, Felipe FariaUniv Fed Sao Paulo, Pediat Dept, Escola Paulista Med, Sao Paulo, SP, Brazil.
(author)
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Aranda, Carolina SanchezUniv Fed Sao Paulo, Pediat Dept, Escola Paulista Med, Sao Paulo, SP, Brazil.
(author)
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Cocco, Renata RodriguesAlbert Einstein Israeli Fac Hlth Sci, Pediat Dept, Sao Paulo, SP, Brazil.
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Cavalcanti Sarinho, Emanuel S.Univ Fed Pernambuco, Pediat Dept, Recife, PE, Brazil.
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Sano, FlavioNipo Brazilian Hosp, Pediat Dept, Sao Paulo, SP, Brazil.
(author)
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Porto Neto, ArnaldoFed Univ Fronteira Sul, Pediat Dept, Passo Fundo, RS, Brazil.
(author)
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Rosario, Nelson A.Univ Fed Parana, Pediat Dept, Curitiba, Parana, Brazil.
(author)
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Chong Neto, Herberto J.Univ Fed Parana, Pediat Dept, Curitiba, Parana, Brazil.
(author)
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Goudouris, Ekaterini SimoesUniv Fed Rio de Janeiro, Pediat Dept, Rio De Janeiro, RJ, Brazil.
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Moraes, Lilian SanchesUniv Fed Mato Grosso, Pediat Dept, Cuiaba, Mato Grosso, Brazil.
(author)
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Wandalsen, Neusa FalboABCs Fdn, Fac Med, Pediat Dept, Santo Andre, SP, Brazil.
(author)
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Pastorino, Antonio CarlosUniv Sao Paulo, Pediat Dept, Sao Paulo, SP, Brazil.
(author)
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Franco, Jackeline MottaUniv Fed Sergipe, Pediat Dept, Aracaju, Sergipe, Brazil.
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Chavarria, Maria LeticiaUniv Fed Goias, Pediat Dept, Goiania, Go, Brazil.
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Borres, Magnus P,1956-Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Thermo Fisher Scientific(Swepub:uu)magbo385
(author)
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Sole, DirceuUniv Fed Sao Paulo, Pediat Dept, Escola Paulista Med, Sao Paulo, SP, Brazil.
(author)
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Univ Fed Sao Paulo, Pediat Dept, Escola Paulista Med, Sao Paulo, SP, Brazil.Albert Einstein Israeli Fac Hlth Sci, Pediat Dept, Sao Paulo, SP, Brazil.
(creator_code:org_t)
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In:Allergologia et Immunopathologia: CODON PUBLICATIONS49:5, s. 42-480301-05461578-1267
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