WFRF:(Liu Yichun)
Search: WFRF:(Liu Yichun) > H2A ubiquitination ...
- 2 of 4
- Previous record
- Next record
- To hitlist
- Liu, ShujingSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för växtbiologi,Department of Plant Biology,Swedish Univ Agr Sci, Dept Plant Biol, S-75007 Uppsala, Sweden.;Linnean Ctr Plant Biol, S-75007 Uppsala, Sweden. (author)
H2A ubiquitination is essential for Polycomb Repressive Complex 1-mediated gene regulation in Marchantia polymorpha
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2021-09-01
- BioMed Central (BMC),2021
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-456222
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-456222URI
- https://doi.org/10.1186/s13059-021-02476-yDOI
- https://res.slu.se/id/publ/113593URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Background Polycomb repressive complex 1 (PRC1) and PRC2 are chromatin regulators maintaining transcriptional repression. The deposition of H3 lysine 27 tri-methylation (H3K27me3) by PRC2 is known to be required for transcriptional repression, whereas the contribution of H2A ubiquitination (H2Aub) in the Polycomb repressive system remains unclear in plants. Results We directly test the requirement of H2Aub for gene regulation in Marchantia polymorpha by generating point mutations in H2A that prevent ubiquitination by PRC1. These mutants show reduced H3K27me3 levels on the same target sites as mutants defective in PRC1 subunits MpBMI1 and the homolog MpBMI1L, revealing that PRC1-catalyzed H2Aub is essential for Polycomb system function. Furthermore, by comparing transcriptome data between mutants in MpH2A and MpBMI1/1L, we demonstrate that H2Aub contributes to the PRC1-mediated transcriptional level of genes and transposable elements. Conclusion Together, our data demonstrates that H2Aub plays a direct role in H3K27me3 deposition and is required for PRC1-mediated transcriptional changes in both genes and transposable elements in Marchantia.
Subject headings and genre
- NATURVETENSKAP Biologi Genetik hsv//swe
- NATURAL SCIENCES Biological Sciences Genetics hsv//eng
- H2Aub
- Gene regulation
- Polycomb
- PRC1
- Marchantia polymorpha
Added entries (persons, corporate bodies, meetings, titles ...)
- Minerva, TrejoSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för växtbiologi,Department of Plant Biology,Swedish Univ Agr Sci, Dept Plant Biol, S-75007 Uppsala, Sweden.;Linnean Ctr Plant Biol, S-75007 Uppsala, Sweden.;John Innes Ctr, Dept Cell & Dev Biol, Norwich NR4 7UH, Norfolk, England.(Swepub:slu)99299 (author)
- Qiu, YichunSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för växtbiologi,Department of Plant Biology,Max Planck Institute for Molecular Plant Physiology,Swedish Univ Agr Sci, Dept Plant Biol, S-75007 Uppsala, Sweden.;Linnean Ctr Plant Biol, S-75007 Uppsala, Sweden.;Max Planck Inst Mol Plant Physiol, D-14476 Potsdam, Germany. (author)
- Eklund, D. MagnusUppsala universitet,Växtekologi och evolution(Swepub:uu)magek348 (author)
- Köhler, ClaudiaSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för växtbiologi,Department of Plant Biology,Max Planck Institute for Molecular Plant Physiology,Swedish Univ Agr Sci, Dept Plant Biol, S-75007 Uppsala, Sweden.;Linnean Ctr Plant Biol, S-75007 Uppsala, Sweden.;Max Planck Inst Mol Plant Physiol, D-14476 Potsdam, Germany.(Swepub:slu)50597 (author)
- Hennigs, LarsSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för växtbiologi,Department of Plant Biology,Swedish Univ Agr Sci, Dept Plant Biol, S-75007 Uppsala, Sweden.;Linnean Ctr Plant Biol, S-75007 Uppsala, Sweden.(Swepub:slu)50109 (author)
- Sveriges lantbruksuniversitetInstitutionen för växtbiologi (creator_code:org_t)
- Sveriges lantbruksuniversitet
Related titles
- In:Genome Biology: BioMed Central (BMC)22:11465-69061474-760X
Internet link
- https://doi.org/10.1186/s13059-021-02476-yFulltext
- https://uu.diva-portal.org/smash/get/diva2:1605603/FULLTEXT01.pdffulltext:print
- https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-021-02476-y
- https://pub.epsilon.slu.se/id/eprint/25365/contentsFULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-456222
- https://doi.org/10.1186/s13059-021-02476-y
- https://res.slu.se/id/publ/113593
Find in a library
- Genome Biology (Search for host publication in LIBRIS)
To the university's database
- 2 of 4
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Liu, Shujing
- Minerva, Trejo
- Qiu, Yichun
- Eklund, D. Magnu ...
- Köhler, Claudia
- Hennigs, Lars
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Genetics
- Articles in the publication
- Genome Biology
- By the university
- Uppsala University
- Swedish University of Agricultural Sciences
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
