Sökning: WFRF:(Jernerén Fredrik) >
Changes in plasma f...
-
Alshahawy, RashaUniv Kafr Elshikh, Fac Med, Dept Physiol, Kafr Elshikh, Egypt.
(författare)
Changes in plasma fatty acids and related biomarkers during transition to an exclusively plant- and fish-based diet in healthy adults
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
-
Elsevier,2021
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-456833
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-456833URI
-
https://doi.org/10.1016/j.nut.2021.111306DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Objective: The aim of this study was to examine the time scale of plasma fatty acid changes during transition to an exclusively plant- and fish-based diet in healthy individuals and determine whether there are associated alterations in arachidonic acid (ARA)-derived inflammatory mediators, estimated stearoyl coenzyme A desaturase (SCD) activity, and blood pressure. Methods: In pursuit of a religious fast, 36 adults abstained from eating poultry, meat, dairy products, and eggs, while increasing fish intake for 6 wk. Participants were assessed 1 wk before (W0) and 1 (WI) and 6 (W6) weeks after the diet change. Results: By W6, fasting plasma long-chain omega-3 polyunsaturated fatty acids (omega-3 LC-PUFAs); docosahexaenoic (DHA) and eicosapentaenoic (EPA) had increased (+67% and +73%, respectively; P <= 0.001), with early rise of DHA (+22%), but not EPA at W1.The omega-3 index (sum of DHA and EPA as a percent of total fatty acids) increased from 2.1% to 3.4%. ARA decreased progressively (W1, -9%; W6, -16%; P < 0.001). ARA precursors gamma-linolenic and dihomo-gamma-linolenic acids also decreased, without changes in the ARA-derived mediators prostaglandin-E2 and leukotriene-B4. Myristic acid decreased at W1 (-37%) and W6 (-40%). There was no consistent change in SCD indices. At W6, systolic and diastolic blood pressure had declined by 8 and 5 mm Hg, respectively (P <= 0.013). Conclusions: Shifting to a plant- and fish-based diet produces rapid and sustained increases in omega-3 LC-PUFAs and decreases the omega-6 PUFA ARA and its precursors, consistent with a cardio-protective profile. The rapid response suggests that these biomarkers may be useful for assessment of diet interventions.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
El Habachi, NihalAlexandria Univ, Alexandria Clin Res Ctr, Alexandria, Egypt.;Univ Alexandria, Fac Med, Dept Physiol, Alexandria, Egypt.
(författare)
-
Allam, EmanUniv Alexandria, Fac Med, Dept Physiol, Alexandria, Egypt.
(författare)
-
Jernerén, FredrikUppsala universitet,Institutionen för farmaceutisk biovetenskap,Univ Oxford, Dept Pharmacol, Oxford, England.(Swepub:uu)frjer991
(författare)
-
Refsum, HelgaUniv Oxford, Dept Pharmacol, Oxford, England.;Univ Oslo, Inst Basic Med Sci, Dept Nutr, Oslo, Norway.
(författare)
-
Elshorbagy, AmanyUniv Alexandria, Fac Med, Dept Physiol, Alexandria, Egypt.;Univ Oxford, Dept Pharmacol, Oxford, England.
(författare)
-
Univ Kafr Elshikh, Fac Med, Dept Physiol, Kafr Elshikh, Egypt.Alexandria Univ, Alexandria Clin Res Ctr, Alexandria, Egypt.;Univ Alexandria, Fac Med, Dept Physiol, Alexandria, Egypt.
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Nutrition (Burbank, Los Angeles County, Calif.): Elsevier900899-90071873-1244
Internetlänk
Hitta via bibliotek
Till lärosätets databas