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Evolution of cytoki...
Evolution of cytokine production capacity in ancient and modern European populations
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- Domínguez-Andrés, Jorge (författare)
- Radboud Univ Nijmegen, Dept Internal Med, Med Ctr, Nijmegen, Netherlands; Radboud Univ Nijmegen, Radboud Ctr Infect Dis RCI, Med Ctr, Nijmegen, Netherlands.;RadboudUniv, Radboud Inst Mol Life Sci RIMLS, Med Ctr, Nijmegen, Netherlands
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- Kuijpers, Yunus (författare)
- Ctr Individualised Infect Med CiiM, Dept Computat Biol Individualised Infect Med, Hannover, Germany; Ctr Expt & Clin Infect Res, TWINCORE, Hannover, Germany
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- Bakker, Olivier B. (författare)
- Univ Med Ctr Groningen, Dept Genet, Nijmegen, Netherlands
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- Jaeger, Martin (författare)
- Radboud Univ Nijmegen, Dept Internal Med, Med Ctr, Nijmegen, Netherlands; Radboud Univ Nijmegen, Radboud Ctr Infect Dis RCI, Med Ctr, Nijmegen, Netherlands.;RadboudUniv, Radboud Inst Mol Life Sci RIMLS, Med Ctr, Nijmegen, Netherlands
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- Xu, Cheng-Jian (författare)
- Radboud Univ Nijmegen, Dept Internal Med, Med Ctr, Nijmegen, Netherlands; Radboud Univ Nijmegen, Radboud Ctr Infect Dis RCI, Med Ctr, Nijmegen, Netherlands; Ctr Individualised Infect Med CiiM, Dept Computat Biol Individualised Infect Med, Hannover, Germany; Ctr Expt & Clin Infect Res, TWINCORE, Hannover, Germany
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- Van der Meer, Jos WM (författare)
- Radboud Univ Nijmegen, Dept Internal Med, Med Ctr, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Radboud Ctr Infect Dis RCI, Med Ctr, Nijmegen, Netherlands
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- Jakobsson, Mattias (författare)
- Uppsala universitet,Människans evolution,Univ Johannesburg, Ctr Anthropol Res, Dept Anthropol & Dev Studies, Auckland Pk, South Africa
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- Bertranpetit, Jaume (författare)
- Univ Pompeu Fabra, Inst Biol Evolut UPF CSIC, Barcelona, Spain
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- Ab Joosten, Leo (författare)
- Radboud Univ Nijmegen, Dept Internal Med, Med Ctr, Nijmegen, Netherlands; Radboud Univ Nijmegen, Radboud Ctr Infect Dis RCI, Med Ctr, Nijmegen, Netherlands; Radboud Univ, Radboud Inst Mol Life Sci RIMLS, Med Ctr, Nijmegen, Netherlands
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- Li, Yang (författare)
- Radboud Univ Nijmegen, Dept Internal Med, Med Ctr, Nijmegen, Netherlands; Radboud Univ Nijmegen, Radboud Ctr Infect Dis RCI, Med Ctr, Nijmegen, Netherlands; Radboud Univ, Radboud Inst Mol Life Sci RIMLS, Med Ctr, Nijmegen, Netherlands; Ctr Individualised Infect Med CiiM, Dept Computat Biol Individualised Infect Med, Hannover, Germany; Ctr Expt & Clin Infect Res, TWINCORE, Hannover, Germany
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- Netea, Mihai G. (författare)
- Radboud Univ Nijmegen, Dept Internal Med, Med Ctr, Nijmegen, Netherlands; Radboud Univ Nijmegen, Radboud Ctr Infect Dis RCI, Med Ctr, Nijmegen, Netherlands; Radboud Univ, Radboud Inst Mol Life Sci RIMLS, Med Ctr, Nijmegen, Netherlands; Univ Bonn, Life & Med Sci Inst LIMES, Dept Genom & Immunoregulat, Bonn, Germany
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Radboud Univ Nijmegen, Dept Internal Med, Med Ctr, Nijmegen, Netherlands; Radboud Univ Nijmegen, Radboud Ctr Infect Dis RCI, Med Ctr, Nijmegen, Netherlands;RadboudUniv, Radboud Inst Mol Life Sci RIMLS, Med Ctr, Nijmegen, Netherlands Ctr Individualised Infect Med CiiM, Dept Computat Biol Individualised Infect Med, Hannover, Germany; Ctr Expt & Clin Infect Res, TWINCORE, Hannover, Germany (creator_code:org_t)
- eLife Sciences Publications Ltd, 2021
- 2021
- Engelska.
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Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 10
- Relaterad länk:
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https://doi.org/10.7...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.7...
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Abstract
Ämnesord
Stäng
- As our ancestors migrated throughout different continents, natural selection increased the presence of alleles advantageous in the new environments. Heritable variations that alter the susceptibility to diseases vary with the historical period, the virulence of the infections, and their geographical spread. In this study we built polygenic scores for heritable traits that influence the genetic adaptation in the production of cytokines and immune-mediated disorders, including infectious, inflammatory, and autoimmune diseases, and applied them to the genomes of several ancient European populations. We observed that the advent of the Neolithic was a turning point for immune-mediated traits in Europeans, favoring those alleles linked with the development of tolerance against intracellular pathogens and promoting inflammatory responses against extracellular microbes. These evolutionary patterns are also associated with an increased presence of traits related to inflammatory and auto-immune diseases.
Ämnesord
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
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Domínguez-Andrés ...
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Kuijpers, Yunus
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Bakker, Olivier ...
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Jaeger, Martin
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Xu, Cheng-Jian
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Van der Meer, Jo ...
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Jakobsson, Matti ...
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Bertranpetit, Ja ...
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Ab Joosten, Leo
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Li, Yang
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Netea, Mihai G.
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