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LVS-HARMED Risk Sco...
LVS-HARMED Risk Score for Incident Heart Failure in Patients With Atrial Fibrillation Who Present to the Emergency Department : Data from a World-Wide Registry
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- Johnson, Linda S.B. (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,McMaster University,Skåne University Hospital
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- Oldgren, Jonas, 1964- (författare)
- Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Barrett, Tyler W. (författare)
- Vanderbilt Univ, Sch Med, Dept Emergency Med, Nashville, TN 37212 USA.,Vanderbilt University
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- McNaughton, Candace D. (författare)
- Vanderbilt Univ, Sch Med, Dept Emergency Med, Nashville, TN 37212 USA.;Tennessee Valley Healthcare Syst VA Med Syst, Geriatr Res Educ & Clin Ctr, Nashville, TN USA.,Vanderbilt University,Nashville Veterans Affairs Medical Center
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- Wong, Jorge A. (författare)
- McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.,McMaster University
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- McIntyre, William F. (författare)
- McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.,McMaster University
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- Freeman, Clifford L. (författare)
- Vanderbilt Univ, Sch Med, Dept Emergency Med, Nashville, TN 37212 USA.,Vanderbilt University
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- Murphy, Laura (författare)
- Vanderbilt Univ, Sch Med, Dept Emergency Med, Nashville, TN 37212 USA.,Vanderbilt University
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- Engström, Gunnar (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Ezekowitz, Michael (författare)
- Sidney Kimmel Med Coll Bryn Mawr Hosp, Lankenau Heart Ctr, Wynnewood, PA USA.,Bryn Mawr Hospital
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- Connolly, Stuart J. (författare)
- McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.,McMaster University
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- Xu, Lizhen (författare)
- McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.,McMaster University
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- Nakamya, Juliet (författare)
- McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.,McMaster University
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- Conen, David (författare)
- McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.,McMaster University
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- Bangdiwala, Shrikant, I (författare)
- McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.,McMaster University
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- Yusuf, Salim (författare)
- McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.,McMaster University
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- Healey, Jeff S. (författare)
- McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.,McMaster University
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(creator_code:org_t)
- Wolters Kluwer, 2021
- 2021
- Engelska.
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Ingår i: Journal of the American Heart Association. - : Wolters Kluwer. - 2047-9980. ; 10:18
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: Heart failure (HF) is a common complication to atrial fibrillation (AF), leading to rehospitalization and death. Early identification of patients with AF at risk for HF might improve outcomes. We aimed to derive a score to predict 1-year risk of new-onset HF after an emergency department (ED) visit with AF.Methods and Results: The RE-LY AF (Randomized Evaluation of Long-Term Anticoagulant Therapy) registry enrolled patients with AF presenting to an ED in 47 countries, and followed them for a year. The end point was HF hospitalization and/or HF death. Among 15 400 ED patients, 9765 had no prior HF (mean age, 64.9 +/- 14.9 years). Within 1 year, new-onset HF developed in 6.8% of patients, of whom 21% died of HF. Independent predictors of HF included left ventricular hypertrophy (odds ratio [OR], 1.47; 95% CI, 1.19-1.82), valvular heart disease (OR, 1.55; 95% CI, 1.18-2.04), smoking (OR, 1.42; 95% CI, 1.12-1.78), height (OR, 0.93; 95% CI, 0.90-0.95 per 3 cm), age (OR, 1.11; 95% CI, 1.07-1.15 per 5 years), rheumatic heart disease (OR, 1.77, 95% CI, 1.24-2.51), prior myocardial infarction (OR, 1.85; 95% CI, 1.45-2.36), remaining in AF at ED discharge (OR, 1.86; 95% CI, 1.46-2.36), and diabetes (OR, 1.33; 95% CI, 1.09-1.64). A continuous risk prediction score (LVS-HARMED [left ventricular, valvular heart disease, smoking or other tobacco use, height, age, rheumatic heart disease, myocardial infarction, emergency department discharge rhythm, and diabetes]) had good discrimination (C statistic, 0.735; 95% CI, 0.716-0.755). Validation was conducted internally using bootstrapping (optimism-corrected C statistic, 0.705) and externally (C statistic, 0.699). The 1-year incidence of HF hospitalization and/or HF death across quartile groups of the score was 1.1%, 4.5%, 6.9%, and 14.4%, respectively. LVS-HARMED also predicted incident stroke (C statistic, 0.753; 95% CI, 0.728-0.778).Conclusions: The LVS-HARMED score predicts new-onset HF after an ED visit for AF. Preventative strategies should be considered in patients with high LVS-HARMED HF risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- atrial fibrillation
- epidemiology
- heart failure
- prevention
- risk score
- risk stratification
- Atrial fibrillation
- Epidemiology
- Heart failure
- Prevention
- Risk score
- Risk stratification
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Johnson, Linda S ...
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Oldgren, Jonas, ...
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Barrett, Tyler W ...
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McNaughton, Cand ...
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Wong, Jorge A.
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McIntyre, Willia ...
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visa fler...
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Freeman, Cliffor ...
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Murphy, Laura
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Engström, Gunnar
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Ezekowitz, Micha ...
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Connolly, Stuart ...
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Xu, Lizhen
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Nakamya, Juliet
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Conen, David
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Bangdiwala, Shri ...
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Yusuf, Salim
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Healey, Jeff S.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Journal of the A ...
- Av lärosätet
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Uppsala universitet
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Lunds universitet