Extending the "resting state hypothesis of depression"-dynamics and topography of abnormal rest-task modulation

Gupta, AnvitaUniv Ottawa, Inst Mental Hlth Res, Mind Brain Imaging & Neuroeth, Ottawa, ON, Canada.;McMaster Univ, Dept Psychol Neurosci & Behav, Hamilton, ON, Canada. (author)

Major depressive disorder (MDD) is characterized by changes in both rest and task states as manifested in temporal dynamics (EEG) and spatial patterns (fMRI). Are rest and task changes related to each other? Extending the "Resting state hypothesis of depression" (RSHD) (Northoff et al., 2011), we, using multimodal imaging, take a tripartite approach: (i) we conduct a review of EEG studies in MDD combining both rest and task states; (ii) we present our own EEG data in MDD on brain dynamics, i.e., intrinsic neural timescales as measured by the autocorrelation window (ACW); and (iii) we review fMRI studies in MDD to probe whether different regions exhibit different rest-task modulation. Review of EEG data shows reduced rest-task change in MDD in different measures of temporal dynamics like peak frequency (and others). Notably, our own EEG data show decreased rest-task change as measured by ACW in frontal electrodes of MDD. The fMRI data reveal that different regions exhibit different rest-task relationships (normal rest-abnormal task, abnormal rest-normal task, abnormal rest abnormal task) in MDD. Together, we demonstrate altered spatiotemporal dynamics of rest-task modulation in MDD; this further supports and extends the key role of the spontaneous activity in MDD as proposed by the RSHD.

Wolff, AnnemarieUniv Ottawa, Inst Mental Hlth Res, Mind Brain Imaging & Neuroeth, Ottawa, ON, Canada. (author)
Northoff, Georg,1961-Uppsala universitet,Centrum för forsknings- och bioetik,Univ Ottawa, Inst Mental Hlth Res, Mind Brain Imaging & Neuroeth, Ottawa, ON, Canada.;Zhejiang Univ, Sch Med, Hosp 7, Mental Hlth Ctr, Hangzhou, Zhejiang, Peoples R China.(Swepub:uu)geono807 (author)
Univ Ottawa, Inst Mental Hlth Res, Mind Brain Imaging & Neuroeth, Ottawa, ON, Canada.;McMaster Univ, Dept Psychol Neurosci & Behav, Hamilton, ON, Canada.Univ Ottawa, Inst Mental Hlth Res, Mind Brain Imaging & Neuroeth, Ottawa, ON, Canada. (creator_code:org_t)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

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