Utilisation Trend of Long-Acting Insulin Analogues including Biosimilars across Europe: Findings and Implications

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Utilisation Trend of Long-Acting Insulin Analogues including Biosimilars across Europe : Findings and Implications

Godman, Brian (författare): Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK;Division of Public Health Pharmacy and Management, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa;School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia

Wladysiuk, Magdalene (författare): Chair of Epidemiology and Preventive Medicine, Medical College, Jagiellonian University, Krakow, Poland;HTA Consulting, Starowiślna Str. 17/3, 31-038 Krakow, Poland

McTaggart, Stuart (författare): Public Health Scotland, Gyle Square, 1 South Gyle Crescent, Edinburgh, UK

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Kurdi, Amanj (författare): Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK;Division of Public Health Pharmacy and Management, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa;Department of Pharmacology, College of Pharmacy, Hawler Medical University, Erbil, Iraq

Allocati, Eleonora (författare): Istituto di Ricerche Farmacologiche ‘Mario Negri’ IRCCS, Milan, Italy

Jakovljevic, Mihajlo (författare): Department of Global Health Economics and Policy, University of Kragujevac, Kragujevac, Serbia;Institute of Comparative Economic Studies, Faculty of Economics, Hosei University Tokyo, Tokyo, Japan

Kalemeera, Francis (författare): Department of Pharmacy Practice and Policy, Faculty of Health Sciences, University of Namibia, Windhoek, Namibia

Hoxha, Iris (författare): Department of Pharmacy, Faculty of Medicine, University of Medicine, Tirana, Albania

Nachtnebel, Anna (författare): Dachverband der Österreichischen Sozialversicherungen, Kundmanngasse 21, AT-1030 Vienna, Austria

Sauermann, Robert (författare): Dachverband der Österreichischen Sozialversicherungen, Kundmanngasse 21, AT-1030 Vienna, Austria

Hinteregger, Manfred (författare): Dachverband der Österreichischen Sozialversicherungen, Kundmanngasse 21, AT-1030 Vienna, Austria

Marković-Peković, Vanda (författare): Faculty of Medicine, Department of Social Pharmacy, University of Banja Luka, Banja Luka, Bosnia and Herzegovina

Tubic, Biljana (författare): Faculty of Medicine, Department of Medicinal Chemistry, University of Banja Luka, Banja Luka, Bosnia and Herzegovina;Agency for Medicinal Product and Medical Devices of Bosnia and Herzegovina, 78000 Banja Luka, Bosnia and Herzegovina

Petrova, Guenka (författare): Faculty of Pharmacy, Department of Social Pharmacy and Pharmacoeconomics, Medical University of Sofia, Sofia, Bulgaria

Tachkov, Konstantin (författare): Faculty of Pharmacy, Department of Social Pharmacy and Pharmacoeconomics, Medical University of Sofia, Sofia, Bulgaria

Slabý, Juraj (författare): State Institute for Drug Control, Prague, Czech Republic

Nejezchlebova, Radka (författare): State Institute for Drug Control, Prague, Czech Republic

Krulichová, Iva Selke (författare): Department of Medical Biophysics, Faculty of Medicine in Hradec Králové, Charles University, Simkova 870, 500 03 Hradec Králové, Czech Republic

Laius, Ott (författare): State Agency of Medicines, Nooruse 1, 50411 Tartu, Estonia

Selke, Gisbert (författare): Wissenschaftliches Institut der AOK (WIdO), Rosenthaler Straße 31, 10178 Berlin, Germany

Langner, Irene (författare): Wissenschaftliches Institut der AOK (WIdO), Rosenthaler Straße 31, 10178 Berlin, Germany

Harsanyi, András (författare): Department of Health Policy and Health Economics, Eotvos Lorand University, Budapest, Hungary

Inotai, András (författare): Syreon Research Institute and Semmelweis University, Center of Health Technology Assessment, Budapest, Hungary

Jakupi, Arianit (författare): Faculty of Pharmacy, UBT Higher Education Institute, Pristina, Kosovo

Henkuzens, Svens (författare): Independent Consultant, Riga, Latvia

Garuolienė, Kristina (författare): Department of Pathology, Forensic Medicine and Pharmacology, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania

Gulbinovič, Jolanta (författare): Department of Pathology, Forensic Medicine and Pharmacology, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania

Bonanno, Patricia Vella (författare): Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK;Department of Health Services Management, University of Malta, Valletta, Malta

Rutkowski, Jakub (författare): HTA Consulting, Starowiślna Str. 17/3, 31-038 Krakow, Poland

Ingeberg, Skule (författare): Medicines Committee, Oslo University Hospitals, Oslo, Norway

Melien, Øyvind (författare): Medicines Committee, Oslo University Hospitals, Oslo, Norway

Mardare, Ileana (författare): Faculty of Medicine, Public Health and Management Department, “Carol Davila” University of Medicine and Pharmacy Bucharest, 050463 Bucharest, Romania

Fürst, Jurij (författare): Health Insurance Institute, Miklosiceva 24, SI-1507 Ljubljana, Slovenia

MacBride-Stewart, Sean (författare): Pharmacy Services, Greater Glasgow and Clyde (NHS GGC), Glasgow, UK

Holmes, Carol (författare): NHS Lothian, Edinburgh, UK

Pontes, Caridad (författare): Drug Department, Catalan Health Service, Gran Via de les Corts Catalanes, 08007 Barcelona, Spain;Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, Barcelona, Spain

Zara, Corinne (författare): Drug Department, Catalan Health Service, Gran Via de les Corts Catalanes, 08007 Barcelona, Spain

Pedrola, Marta Turu (författare): Drug Department, Catalan Health Service, Gran Via de les Corts Catalanes, 08007 Barcelona, Spain

Hoffmann, Mikael (författare): NEPI-Nätverk för läkemedelsepidemiologi, Stockholm, Sweden

Kourafalos, Vasileios (författare): National Organization for the Provision of Healthcare Services (EOPYY), Athens, Greece

Pisana, Alice (författare): Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden

Banzi, Rita (författare): Istituto di Ricerche Farmacologiche ‘Mario Negri’ IRCCS, Milan, Italy

Campbell, Stephen (författare): Centre for Primary Care and Health Services Research, School of Health Sciences, University of Manchester, Manchester M13 9PL, UK;NIHR Greater Manchester Patient Safety Translational Research Centre, School of Health Sciences, University of Manchester, Manchester, UK

Wettermark, Björn (författare): Uppsala universitet,Institutionen för farmaci,Pharmacoepidemiology

Melien, O (författare)

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Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK;Division of Public Health Pharmacy and Management, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa;School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia Chair of Epidemiology and Preventive Medicine, Medical College, Jagiellonian University, Krakow, Poland;HTA Consulting, Starowiślna Str 17/3, 31-038 Krakow, Poland (creator_code:org_t)

Hindawi Publishing Corporation, 2021
2021
Engelska.
Ingår i: BioMed Research International. - : Hindawi Publishing Corporation. - 2314-6133 .- 2314-6141. ; 2021

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://downloads.hi...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; visa färre...

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Background. Diabetes mellitus rates and associated costs continue to rise across Europe enhancing health authority focus on its management. The risk of complications is enhanced by poor glycaemic control, with long-acting insulin analogues developed to reduce hypoglycaemia and improve patient convenience. There are concerns though with their considerably higher costs, but moderated by reductions in complications and associated costs. Biosimilars can help further reduce costs. However, to date, price reductions for biosimilar insulin glargine appear limited. In addition, the originator company has switched promotional efforts to more concentrated patented formulations to reduce the impact of biosimilars. There are also concerns with different devices between the manufacturers. As a result, there is a need to assess current utilisation rates for insulins, especially long-acting insulin analogues and biosimilars, and the rationale for patterns seen, among multiple European countries to provide future direction.Methodology. Health authority databases are examined to assess utilisation and expenditure patterns for insulins, including biosimilar insulin glargine. Explanations for patterns seen were provided by senior-level personnel.Results. Typically increasing use of long-acting insulin analogues across Europe including both Western and Central and Eastern European countries reflects perceived patient benefits despite higher prices. However, activities by the originator company to switch patients to more concentrated insulin glargine coupled with lowering prices towards biosimilars have limited biosimilar uptake, with biosimilars not currently launched in a minority of European countries. A number of activities were identified to address this. Enhancing the attractiveness of the biosimilar insulin market is essential to encourage other biosimilar manufacturers to enter the market as more long-acting insulin analogues lose their patents to benefit all key stakeholder groups.Conclusions. There are concerns with the availability and use of insulin glargine biosimilars among European countries despite lower costs. This can be addressed.

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Av författaren/redakt...: Godman, Brian; Wladysiuk, Magda ...; McTaggart, Stuar ...; Kurdi, Amanj; Allocati, Eleono ...; Jakovljevic, Mih ...; visa fler...; Kalemeera, Franc ...; Hoxha, Iris; Nachtnebel, Anna; Sauermann, Rober ...; Hinteregger, Man ...; Marković-Peković ...; Tubic, Biljana; Petrova, Guenka; Tachkov, Konstan ...; Slabý, Juraj; Nejezchlebova, R ...; Krulichová, Iva ...; Laius, Ott; Selke, Gisbert; Langner, Irene; Harsanyi, András; Inotai, András; Jakupi, Arianit; Henkuzens, Svens; Garuolienė, Kris ...; Gulbinovič, Jola ...; Bonanno, Patrici ...; Rutkowski, Jakub; Ingeberg, Skule; Melien, Øyvind; Mardare, Ileana; Fürst, Jurij; MacBride-Stewart ...; Holmes, Carol; Pontes, Caridad; Zara, Corinne; Pedrola, Marta T ...; Hoffmann, Mikael; Kourafalos, Vasi ...; Pisana, Alice; Banzi, Rita; Campbell, Stephe ...; Wettermark, Björ ...; Melien, O; visa färre...

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Utilisation Trend of Long-Acting Insulin Analogues including Biosimilars across Europe : Findings and Implications

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