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Ultrasound-Responsi...
Ultrasound-Responsive Smart Drug Delivery System of Lipid Coated Mesoporous Silica Nanoparticles
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- Amin, Muhammad Umair (författare)
- Dept Pharmaceut & Biopharmaceut, Univ Marburg, Robert Koch Str 4, D-35037 Marburg, Germany.
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- Ali, Sajid (författare)
- Uppsala universitet,Fysikalisk kemi,Dept Pharmaceut & Biopharmaceut, Univ Marburg, Robert Koch Str 4, D-35037 Marburg, Germany
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- Tariq, Imran (författare)
- Dept Pharmaceut & Biopharmaceut, Univ Marburg, Robert Koch Str 4, D-35037 Marburg, Germany.;Univ Punjab, Coll Pharm, Lahore 54000, Pakistan.
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- Ali, Muhammad Yasir (författare)
- Dept Pharmaceut & Biopharmaceut, Univ Marburg, Robert Koch Str 4, D-35037 Marburg, Germany.;GC Univ Faisalabad, Fac Pharmaceut Sci, Faisalabad 38000, Pakistan.
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- Pinnapreddy, Shashank Reddy (författare)
- Dept Pharmaceut & Biopharmaceut, Univ Marburg, Robert Koch Str 4, D-35037 Marburg, Germany.
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- Preis, Eduard (författare)
- Dept Pharmaceut & Biopharmaceut, Univ Marburg, Robert Koch Str 4, D-35037 Marburg, Germany.
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- Woelk, Christian (författare)
- Univ Leipzig, Fac Med, Inst Pharm Pharmaceut Technol, Eilenburger Str 15a, D-04317 Leipzig, Germany.
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- Harvey, Richard D. (författare)
- Univ Vienna, Dept Pharmaceut Chem, Althanstr 14, A-1090 Vienna, Austria.
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- Hause, Gerd (författare)
- Martin Luther Univ Halle Wittenberg, Bioctr, Weinbergweg 22, D-06120 Halle, Germany.
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- Bruessler, Jana (författare)
- Dept Pharmaceut & Biopharmaceut, Univ Marburg, Robert Koch Str 4, D-35037 Marburg, Germany.
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- Bakowsky, Udo (författare)
- Dept Pharmaceut & Biopharmaceut, Univ Marburg, Robert Koch Str 4, D-35037 Marburg, Germany.
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Dept Pharmaceut & Biopharmaceut, Univ Marburg, Robert Koch Str 4, D-35037 Marburg, Germany Fysikalisk kemi (creator_code:org_t)
- 2021-09-03
- 2021
- Engelska.
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Ingår i: Pharmaceutics. - : MDPI. - 1999-4923. ; 13:9
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- The immediate release of chemotherapeutics at the target site, along with no premature release in circulation is always challenging. The purpose of this study was to develop a stimuli responsive drug delivery system, composed of lipid supported mesoporous silica nanoparticles (MSNPs) for triggered drug release at the target site and simultaneously avoiding the premature release. MSNPs with a higher drug loading capacity and very slow release were designed so as to enhance release by FDA approved US-irradiation. Doxorubicin, as a model drug, and perfluoropentane (PFP) as a US responsive material, were entrapped in the porous structure of MSNPs. Lipid coating enhanced the cellular uptake and in addition provided a gatekeeping effect at the pore opening to reduce premature release. The mechanical and thermal effects of US induced the conversion of liquid PFP to a gaseous form that was able to rupture the lipid layer, resulting in triggered drug release. The prolonged stability profile and non-toxic behavior made them suitable candidate for the delivery of anticancer drugs. This smart system, with the abilities of better cellular uptake and higher cytotoxic effects on US-irradiation, would be a good addition to the applied side of chemotherapeutic advanced drug delivery systems.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- mesoporous silica nanoparticles
- lipid coating
- ultrasound triggered release
- mechanical index
- cellular uptake
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Amin, Muhammad U ...
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Ali, Sajid
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Tariq, Imran
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Ali, Muhammad Ya ...
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Pinnapreddy, Sha ...
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Preis, Eduard
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visa fler...
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Woelk, Christian
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Harvey, Richard ...
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Hause, Gerd
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Bruessler, Jana
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Bakowsky, Udo
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Farmaceutiska ve ...
- Artiklar i publikationen
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Pharmaceutics
- Av lärosätet
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Uppsala universitet