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Interleukin-13 :
Interleukin-13 : A pivotal target against influenza-induced exacerbation of chronic lung diseases
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- Shastri, Madhur D. (author)
- Univ Tasmania, Sch Pharm & Pharmacol, Hobart, Tas 7005, Australia.
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- Allam, Venkata (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Shukla, Shakti D. (author)
- Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, POB 123 Broadway, Sydney, NSW 2007, Australia.;Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Ultimo, NSW 2007, Australia.
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- Jha, Niraj Kumar (author)
- Sharda Univ, Sch Engn & Technol SET, Dept Biotechnol, Greater Noida, UP, India.
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- Paudel, Keshav Raj (author)
- Centenary Inst, Ctr Inflammat, Sydney, NSW 2050, Australia.;Univ Technol Sydney, Fac Sci, Sch Life Sci, Sydney, NSW 2007, Australia.
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- Peterson, Gregory M. (author)
- Univ Tasmania, Sch Pharm & Pharmacol, Hobart, Tas 7005, Australia.
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- Patel, Rahul P. (author)
- Univ Tasmania, Sch Pharm & Pharmacol, Hobart, Tas 7005, Australia.
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- Hansbro, Philip M. (author)
- Centenary Inst, Ctr Inflammat, Sydney, NSW 2050, Australia.;Univ Technol Sydney, Fac Sci, Sch Life Sci, Sydney, NSW 2007, Australia.
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- Chellappan, Dinesh K. (author)
- Int Med Univ IMU, Sch Pharm, Dept Life Sci, Kuala Lumpur, Malaysia.
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- Dua, Kamal (author)
- Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, POB 123 Broadway, Sydney, NSW 2007, Australia.;Centenary Inst, Ctr Inflammat, Sydney, NSW 2050, Australia.;Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Ultimo, NSW 2007, Australia.
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Univ Tasmania, Sch Pharm & Pharmacol, Hobart, Tas 7005, Australia Institutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)
- Elsevier, 2021
- 2021
- English.
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In: Life Sciences. - : Elsevier. - 0024-3205 .- 1879-0631. ; 283
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Non-communicable, chronic respiratory diseases (CRDs) affect millions of individuals worldwide. The course of these CRDs (asthma, chronic obstructive pulmonary disease, and cystic fibrosis) are often punctuated by microbial infections that may result in hospitalization and are associated with increased risk of morbidity and mortality, as well as reduced quality of life. Interleukin-13 (IL-13) is a key protein that regulates airway inflammation and mucus hypersecretion. There has been much interest in IL-13 from the last two decades. This cytokine is believed to play a decisive role in the exacerbation of inflammation during the course of viral infections, especially, in those with pre-existing CRDs. Here, we discuss the common viral infections in CRDs, as well as the potential role that IL-13 plays in the virus-induced disease pathogenesis of CRDs. We also discuss, in detail, the immune-modulation potential of IL-13 that could be translated to in-depth studies to develop IL-13based therapeutic entities.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- IL-13
- Chronic respiratory diseases (CRDs)
- Asthma
- COPD
- Cystic fibrosis
- COVID
- IL-33
- Eosinophils
- Innate lymphoid cells (ILC2s)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Shastri, Madhur ...
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Allam, Venkata
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Shukla, Shakti D ...
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Jha, Niraj Kumar
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Paudel, Keshav R ...
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Peterson, Gregor ...
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Patel, Rahul P.
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Hansbro, Philip ...
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Chellappan, Dine ...
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Dua, Kamal
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Life Sciences
- By the university
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Uppsala University