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Hemoglobin A1c and ...
Hemoglobin A1c and Fructosamine Evaluated in Patients with Type 2 Diabetes Receiving Peritoneal Dialysis Using Long-Term Continuous Glucose Monitoring
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- Bomholt, Tobias (author)
- Department of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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- Feldt-Rasmussen, Bo (author)
- Department of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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- Butt, Rizwan (author)
- Department of Nephrology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
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- Borg, Rikke (author)
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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- Sarwary, Mir Hassan (author)
- Department of Nephrology, Hillerød Hospital, University of Copenhagen, Hillerød, Denmark
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- Elung-Jensen, Thomas (author)
- Department of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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- Almdal, Thomas (author)
- Department of Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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- Knop, Filip K (author)
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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- Nørgaard, Kirsten (author)
- Steno Diabetes Center Copenhagen, Gentofte, Denmark
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- Ranjan, Ajenthen G (author)
- Steno Diabetes Center Copenhagen, Gentofte, Denmark
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- Larsson, Anders (author)
- Uppsala universitet,Klinisk kemi
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- Rix, Marianne (author)
- Department of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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- Hornum, Mads (author)
- Department of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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(creator_code:org_t)
- 2021-11-03
- 2022
- English.
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In: Nephron. Clinical practice. - : S. Karger. - 1660-8151 .- 2235-3186. ; 146:2, s. 146-152
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Introduction: Shortened erythrocyte life span and erythropoietin-stimulating agents may affect hemoglobin A1c (HbA1c) levels in patients receiving peritoneal dialysis (PD). We compared HbA1c with interstitial glucose measured by continuous glucose monitoring (CGM) in patients with type 2 diabetes receiving PD.Methods: Fourteen days of CGM (Ipro2, Medtronic) were performed in 23 patients with type 2 diabetes receiving PD and in 23 controls with type 2 diabetes and an estimated glomerular filtration rate over 60 mL/min/1.73 m2. Patients were matched on gender and age (±5 years). HbA1c (mmol/mol), its derived estimate of mean plasma glucose (eMPGA1c) (mmol/L), and fructosamine (µmol/L) were measured at the end of the CGM period and compared with the mean sensor glucose (mmol/L) from CGM.Results: In the PD group, mean sensor glucose was 0.98 (95% con-fidence interval (CI): 0.43-1.54) mmol/L higher than the eMPGA1c compared with the control group (p = 0.002) where glucose levels were nearly identical (-0.05 (95% CI: -0.35-0.25) mmol/L). A significant association was found between fructosamine and mean sensor glucose using linear regression with no difference between slopes (p = 0.89) or y-intercepts (p = 0.28).Discussion/Conclusion: HbA1c underestimates mean plasma glucose levels in patients with type 2 diabetes receiving PD. However, the clinical significance of this finding is undetermined. Fructosamine seems to more accurately reflect glycemic status. CGM or fructosamine could complement HbA1c to increase the accuracy of glycemic monitoring in the PD population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Continuous glucose monitoring
- Diabetic nephropathy
- Fructosamine
- Hemoglobin A1c
- Peritoneal dialysis
Publication and Content Type
- ref (subject category)
- art (subject category)
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Bomholt, Tobias
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Feldt-Rasmussen, ...
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Butt, Rizwan
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Borg, Rikke
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Sarwary, Mir Has ...
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Elung-Jensen, Th ...
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Almdal, Thomas
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Knop, Filip K
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Nørgaard, Kirste ...
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Ranjan, Ajenthen ...
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Larsson, Anders
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Rix, Marianne
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Hornum, Mads
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Nephron. Clinica ...
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Uppsala University