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  • Bomholt, TobiasDepartment of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark (författare)

Hemoglobin A1c and Fructosamine Evaluated in Patients with Type 2 Diabetes Receiving Peritoneal Dialysis Using Long-Term Continuous Glucose Monitoring

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2021-11-03
  • S. Karger,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-457974
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-457974URI
  • https://doi.org/10.1159/000519493DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Introduction: Shortened erythrocyte life span and erythropoietin-stimulating agents may affect hemoglobin A1c (HbA1c) levels in patients receiving peritoneal dialysis (PD). We compared HbA1c with interstitial glucose measured by continuous glucose monitoring (CGM) in patients with type 2 diabetes receiving PD.Methods: Fourteen days of CGM (Ipro2, Medtronic) were performed in 23 patients with type 2 diabetes receiving PD and in 23 controls with type 2 diabetes and an estimated glomerular filtration rate over 60 mL/min/1.73 m2. Patients were matched on gender and age (±5 years). HbA1c (mmol/mol), its derived estimate of mean plasma glucose (eMPGA1c) (mmol/L), and fructosamine (µmol/L) were measured at the end of the CGM period and compared with the mean sensor glucose (mmol/L) from CGM.Results: In the PD group, mean sensor glucose was 0.98 (95% con-fidence interval (CI): 0.43-1.54) mmol/L higher than the eMPGA1c compared with the control group (p = 0.002) where glucose levels were nearly identical (-0.05 (95% CI: -0.35-0.25) mmol/L). A significant association was found between fructosamine and mean sensor glucose using linear regression with no difference between slopes (p = 0.89) or y-intercepts (p = 0.28).Discussion/Conclusion: HbA1c underestimates mean plasma glucose levels in patients with type 2 diabetes receiving PD. However, the clinical significance of this finding is undetermined. Fructosamine seems to more accurately reflect glycemic status. CGM or fructosamine could complement HbA1c to increase the accuracy of glycemic monitoring in the PD population.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Feldt-Rasmussen, BoDepartment of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark (författare)
  • Butt, RizwanDepartment of Nephrology, Herlev Hospital, University of Copenhagen, Herlev, Denmark (författare)
  • Borg, RikkeDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (författare)
  • Sarwary, Mir HassanDepartment of Nephrology, Hillerød Hospital, University of Copenhagen, Hillerød, Denmark (författare)
  • Elung-Jensen, ThomasDepartment of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark (författare)
  • Almdal, ThomasDepartment of Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark (författare)
  • Knop, Filip KDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (författare)
  • Nørgaard, KirstenSteno Diabetes Center Copenhagen, Gentofte, Denmark (författare)
  • Ranjan, Ajenthen GSteno Diabetes Center Copenhagen, Gentofte, Denmark (författare)
  • Larsson, AndersUppsala universitet,Klinisk kemi(Swepub:uu)andlarss (författare)
  • Rix, MarianneDepartment of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark (författare)
  • Hornum, MadsDepartment of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark (författare)
  • Department of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, DenmarkDepartment of Nephrology, Herlev Hospital, University of Copenhagen, Herlev, Denmark (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nephron. Clinical practice: S. Karger146:2, s. 146-1521660-81512235-3186

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