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Sökning: L773:1527 7755 OR L773:0732 183X > (2020-2024) > Clinicopathologic F...

Clinicopathologic Features and Response to Therapy of NRG1 Fusion-Driven Lung Cancers : The eNRGy1 Global Multicenter Registry

Drilon, Alexander (författare)
Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10065 USA.;Weill Cornell Med Coll, New York, NY USA.
Duruisseaux, Michael (författare)
Hosp Civils Lyon, Louis Pradel Hosp, Resp Dept, Canc Inst, Lyon, France.;Canc Res Ctr Lyon, Anticanc Antibodies Lab, Lyon, France.;Univ Lyon, Univ Claude Bernard Lyon, UMR INSERM 1052 CNRS 528, Lyon, France.
Han, Ji-Youn (författare)
Natl Canc Ctr, Goyang Si, South Korea.
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Ito, Masaoki (författare)
Quiron Dexeus Univ Inst, Pangaea Oncol, Barcelona, Spain.;Inst Hlth Sci Res Germans Trias & Pujol IGTP, Badalona, Spain.;Hiroshima Univ, Res Inst Radiat Biol & Med, Hiroshima, Japan.
Falcon, Christina (författare)
Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10065 USA.;Weill Cornell Med Coll, New York, NY USA.
Yang, Soo-Ryum (författare)
Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10065 USA.;Weill Cornell Med Coll, New York, NY USA.
Murciano-Goroff, Yonina R. (författare)
Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10065 USA.
Chen, Haiquan (författare)
Fudan Univ, Shanghai Canc Ctr, Shanghai Med Coll, Shanghai, Peoples R China.;Fudan Univ, Sch Life Sci, Inst Thorac Oncol, State Key Lab Genet Engn, Shanghai, Peoples R China.
Okada, Morihito (författare)
Hiroshima Univ, Res Inst Radiat Biol & Med, Hiroshima, Japan.
Molina, Miguel Angel (författare)
Quiron Dexeus Univ Inst, Lab Mol Biol, Pangaea Oncol, Barcelona, Spain.
Wislez, Marie (författare)
Sorbonne Univ, INSERM, Ctr Rech Cordeliers, Univ Paris, Paris, France.;Hop Cochin, AP HP, Pulmonol Dept, Team Inflammat Complement & Canc, Paris, France.;Hop Cochin, AP HP, Pulmonol Dept, Oncol Thorac Unit, Paris, France.
Brun, Philippe (författare)
Helios Klinikum Emil von Behring, Lungenklin Heckeshorn, Dept Pneumol, Valence, France.
Dupont, Clarisse (författare)
Hosp Civils Lyon, Louis Pradel Hosp, Resp Dept, Canc Inst, Lyon, France.
Brandén, Eva (författare)
Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Karolinska Inst, Stockholm, Sweden.;Karolinska Univ Hosp Solna, Stockholm, Sweden.
Rossi, Giulio (författare)
Infermi Hosp, Local Hlth Author Romagna, Rimini, Italy.;St Maria delle Croci Hosp, Local Hlth Author Romagna, Ravenna, Italy.
Schrock, Alexa (författare)
Fdn Med Inc, Cambridge, MA USA.
Ali, Siraj (författare)
Fdn Med Inc, Cambridge, MA USA.
Gounant, Valerie (författare)
Hop Tenon, Assistance Publ Hop Paris, Dept Pulmonol, Paris, France.
Magne, Fanny (författare)
Hop Nord Ouest Villefranche Sur Saone, Gleize, France.
Blum, Torsten Gerriet (författare)
Klinikum Emil von Behring, Dept Pneumol, Berlin, Germany.
Schram, Alison M. (författare)
Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10065 USA.
Monnet, Isabelle (författare)
Ctr Hosp Intercommunal Creteil, Creteil, France.
Shih, Jin-Yuan (författare)
Natl Taiwan Univ, Natl Taiwan Univ Hosp, Taipei, Taiwan.;Natl Taiwan Univ, Coll Med, Taipei, Taiwan.
Sabari, Joshua (författare)
New York Univ Langone Hlth, Perlmutter Canc Ctr, New York, NY USA.
Perol, Maurice (författare)
Leon Berard Canc Ctr, Lyon, France.
Zhu, Viola W. (författare)
Univ Calif Irvine, Irvine Sch Med, Dept Med, Div Hematol Oncol,Chao Family Comprehens Canc Ctr, Orange, CA 92668 USA.
Nagasaka, Misako (författare)
Wayne State Univ, Karmanos Canc Inst, Detroit, MI USA.;St Marianna Univ, Dept Internal Med, Div Neurol, Kawasaki, Kanagawa, Japan.
Doebele, Robert (författare)
Univ Colorado, Div Med Oncol, Canc Ctr, Aurora, CO USA.
Camidge, D. Ross (författare)
Univ Colorado, Div Med Oncol, Canc Ctr, Aurora, CO USA.
Arcila, Maria (författare)
Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10065 USA.;Weill Cornell Med Coll, New York, NY USA.
Ou, Sai-Hong Ignatius (författare)
Univ Calif Irvine, Irvine Med Ctr, Chao Family Comprehens Canc Ctr, Orange, CA 92668 USA.
Moro-Sibilot, Denis (författare)
Ctr Hosp Univ Grenoble, Pole Med Aigue Communautaire, Clin Pneumol, Grenoble, France.
Rosell, Rafael (författare)
Hosp Badalona Germans Trias & Pujol, Catalan Inst Oncol, Badalona, Spain.
Muscarella, Lucia Anna (författare)
Fdn IRCCS Casa Sollievo della Sofferenza, Lab Oncol, Foggia, Italy.
Liu, Stephen, V (författare)
Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA.
Cadranel, Jacques (författare)
Sorbonne Univ, Tenon Hosp, Assistance Publ Hop Paris, Dept Pneumol & Thorac Oncol, Paris, France.;Sorbonne Univ, GRC Theranoscan, Paris, France.
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Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10065 USA;Weill Cornell Med Coll, New York, NY USA. Hosp Civils Lyon, Louis Pradel Hosp, Resp Dept, Canc Inst, Lyon, France.;Canc Res Ctr Lyon, Anticanc Antibodies Lab, Lyon, France.;Univ Lyon, Univ Claude Bernard Lyon, UMR INSERM 1052 CNRS 528, Lyon, France. (creator_code:org_t)
LIPPINCOTT WILLIAMS & WILKINS, 2021
2021
Engelska.
Ingår i: Journal of Clinical Oncology. - : LIPPINCOTT WILLIAMS & WILKINS. - 0732-183X .- 1527-7755. ; 39:25, s. 2791-2802
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • PURPOSE Although NRG1 fusions are oncogenic drivers across multiple tumor types including lung cancers, these are difficult to study because of their rarity. The global eNRGy1 registry was thus established to characterize NRG1 fusion-positive lung cancers in the largest and most diverse series to date. METHODS From June 2018 to February 2020, a consortium of 22 centers from nine countries in Europe, Asia, and the United States contributed data from patients with pathologically confirmed NRG1 fusion-positive lung cancers. Profiling included DNA-based and/or RNA-based next-generation sequencing and fluorescence in situ hybridization. Anonymized clinical, pathologic, molecular, and response (RECIST v1.1) data were centrally curated and analyzed. RESULTS Although the typified never smoking (57%), mucinous adenocarcinoma (57%), and nonmetastatic (71%) phenotype predominated in 110 patients with NRG1 fusion-positive lung cancer, further diversity, including in smoking history (43%) and histology (43% nonmucinous and 6% nonadenocarcinoma), was elucidated. RNA-based testing identified most fusions (74%). Molecularly, six (of 18) novel 5 ' partners, 20 unique epidermal growth factor domain-inclusive chimeric events, and heterogeneous 5 '/3 ' breakpoints were found. Platinum-doublet and taxane-based (post-platinum-doublet) chemotherapy achieved low objective response rates (ORRs 13% and 14%, respectively) and modest progression-free survival medians (PFS 5.8 and 4.0 months, respectively). Consistent with a low programmed death ligand-1 expressing (28%) and low tumor mutational burden (median: 0.9 mutations/megabase) immunophenotype, the activity of chemoimmunotherapy and single-agent immunotherapy was poor (ORR 0%/PFS 3.3 months and ORR 20%/PFS 3.6 months, respectively). Afatinib achieved an ORR of 25%, not contingent on fusion type, and a 2.8-month median PFS. CONCLUSION NRG1 fusion-positive lung cancers were molecularly, pathologically, and clinically more heterogeneous than previously recognized. The activity of cytotoxic, immune, and targeted therapies was disappointing. Further research examining NRG1-rearranged tumor biology is needed to develop new therapeutic strategies.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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