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Comparative epigene...
Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma
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- Vinel, Claire (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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- Rosser, Gabriel (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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- Guglielmi, Loredana (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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- Constantinou, Myrianni (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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- Pomella, Nicola (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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- Zhang, Xinyu (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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- Boot, James R. (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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- Jones, Tania A. (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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- Millner, Thomas O. (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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- Dumas, Anaelle A. (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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- Rakyan, Vardhman (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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- Rees, Jeremy (author)
- Univ Coll London Hosp NHS Fdn Trust, Natl Hosp Neurol & Neurosurg, Div Neuropathol, Queen Sq, London, England.
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- Thompson, Jamie L. (author)
- Univ Nottingham, Biodiscovery Inst, Stem Cell Glycobiol Grp, Nottingham, England.
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- Vuononvirta, Juho (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.
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- Nadkarni, Suchita (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.
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- El Assan, Tedani (author)
- Univ Coll London Hosp NHS Fdn Trust, Natl Hosp Neurol & Neurosurg, Div Neuropathol, Queen Sq, London, England.
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- Aley, Natasha (author)
- UCL Queen Sq Inst Neurol, Dept Neurodegenerat Dis, Queen Sq, London, England.
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- Lin, Yung-Yao (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.;Queen Mary Univ London, Natl Bowel Res Ctr, Barts & London Sch Med & Dent, Stem Cell Lab, 2 Newark St, London, England.
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- Liu, Pentao (author)
- Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Peoples R China.
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- Nelander, Sven (author)
- Uppsala universitet,Neuroonkologi
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- Sheer, Denise (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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- Merry, Catherine L. R. (author)
- Univ Nottingham, Biodiscovery Inst, Stem Cell Glycobiol Grp, Nottingham, England.
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- Marelli-Berg, Federica (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.
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- Brandner, Sebastian (author)
- Univ Coll London Hosp NHS Fdn Trust, Natl Hosp Neurol & Neurosurg, Div Neuropathol, Queen Sq, London, England.;UCL Queen Sq Inst Neurol, Dept Neurodegenerat Dis, Queen Sq, London, England.
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- Marino, Silvia (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England Univ Coll London Hosp NHS Fdn Trust, Natl Hosp Neurol & Neurosurg, Div Neuropathol, Queen Sq, London, England. (creator_code:org_t)
- 2021-10-21
- 2021
- English.
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 12:1
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Abstract
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- Epigenetic mechanisms which play an essential role in normal developmental processes, such as self-renewal and fate specification of neural stem cells (NSC) are also responsible for some of the changes in the glioblastoma (GBM) genome. Here we develop a strategy to compare the epigenetic and transcriptional make-up of primary GBM cells (GIC) with patient-matched expanded potential stem cell (EPSC)-derived NSC (iNSC). Using a comparative analysis of the transcriptome of syngeneic GIC/iNSC pairs, we identify a glycosaminoglycan (GAG)-mediated mechanism of recruitment of regulatory T cells (Tregs) in GBM. Integrated analysis of the transcriptome and DNA methylome of GBM cells identifies druggable target genes and patient-specific prediction of drug response in primary GIC cultures, which is validated in 3D and in vivo models. Taken together, we provide a proof of principle that this experimental pipeline has the potential to identify patient-specific disease mechanisms and druggable targets in GBM. The identification of patient-specific disease mechanisms and druggable targets is crucial for precision medicine in glioblastoma. Here, the authors show that comparing patients-matched glioma-initiating cells with neural stem cells enables the discovery of patient-specific mechanisms of disease and the identification of effective drugs
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Vinel, Claire
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Rosser, Gabriel
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Guglielmi, Lored ...
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Constantinou, My ...
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Pomella, Nicola
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Zhang, Xinyu
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show more...
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Boot, James R.
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Jones, Tania A.
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Millner, Thomas ...
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Dumas, Anaelle A ...
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Rakyan, Vardhman
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Rees, Jeremy
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Thompson, Jamie ...
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Vuononvirta, Juh ...
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Nadkarni, Suchit ...
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El Assan, Tedani
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Aley, Natasha
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Lin, Yung-Yao
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Liu, Pentao
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Nelander, Sven
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Sheer, Denise
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Merry, Catherine ...
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Marelli-Berg, Fe ...
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Brandner, Sebast ...
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Marino, Silvia
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Nature Communica ...
- By the university
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Uppsala University