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  • Vinel, ClaireQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England. (author)

Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-10-21
  • Springer Nature,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-458802
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-458802URI
  • https://doi.org/10.1038/s41467-021-26297-6DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Epigenetic mechanisms which play an essential role in normal developmental processes, such as self-renewal and fate specification of neural stem cells (NSC) are also responsible for some of the changes in the glioblastoma (GBM) genome. Here we develop a strategy to compare the epigenetic and transcriptional make-up of primary GBM cells (GIC) with patient-matched expanded potential stem cell (EPSC)-derived NSC (iNSC). Using a comparative analysis of the transcriptome of syngeneic GIC/iNSC pairs, we identify a glycosaminoglycan (GAG)-mediated mechanism of recruitment of regulatory T cells (Tregs) in GBM. Integrated analysis of the transcriptome and DNA methylome of GBM cells identifies druggable target genes and patient-specific prediction of drug response in primary GIC cultures, which is validated in 3D and in vivo models. Taken together, we provide a proof of principle that this experimental pipeline has the potential to identify patient-specific disease mechanisms and druggable targets in GBM. The identification of patient-specific disease mechanisms and druggable targets is crucial for precision medicine in glioblastoma. Here, the authors show that comparing patients-matched glioma-initiating cells with neural stem cells enables the discovery of patient-specific mechanisms of disease and the identification of effective drugs

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rosser, GabrielQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England. (author)
  • Guglielmi, LoredanaQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England. (author)
  • Constantinou, MyrianniQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England. (author)
  • Pomella, NicolaQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England. (author)
  • Zhang, XinyuQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England. (author)
  • Boot, James R.Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England. (author)
  • Jones, Tania A.Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England. (author)
  • Millner, Thomas O.Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England. (author)
  • Dumas, Anaelle A.Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England. (author)
  • Rakyan, VardhmanQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England. (author)
  • Rees, JeremyUniv Coll London Hosp NHS Fdn Trust, Natl Hosp Neurol & Neurosurg, Div Neuropathol, Queen Sq, London, England. (author)
  • Thompson, Jamie L.Univ Nottingham, Biodiscovery Inst, Stem Cell Glycobiol Grp, Nottingham, England. (author)
  • Vuononvirta, JuhoQueen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England. (author)
  • Nadkarni, SuchitaQueen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England. (author)
  • El Assan, TedaniUniv Coll London Hosp NHS Fdn Trust, Natl Hosp Neurol & Neurosurg, Div Neuropathol, Queen Sq, London, England. (author)
  • Aley, NatashaUCL Queen Sq Inst Neurol, Dept Neurodegenerat Dis, Queen Sq, London, England. (author)
  • Lin, Yung-YaoQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.;Queen Mary Univ London, Natl Bowel Res Ctr, Barts & London Sch Med & Dent, Stem Cell Lab, 2 Newark St, London, England. (author)
  • Liu, PentaoUniv Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Peoples R China. (author)
  • Nelander, SvenUppsala universitet,Neuroonkologi(Swepub:uu)svene843 (author)
  • Sheer, DeniseQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England. (author)
  • Merry, Catherine L. R.Univ Nottingham, Biodiscovery Inst, Stem Cell Glycobiol Grp, Nottingham, England. (author)
  • Marelli-Berg, FedericaQueen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England. (author)
  • Brandner, SebastianUniv Coll London Hosp NHS Fdn Trust, Natl Hosp Neurol & Neurosurg, Div Neuropathol, Queen Sq, London, England.;UCL Queen Sq Inst Neurol, Dept Neurodegenerat Dis, Queen Sq, London, England. (author)
  • Marino, SilviaQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England. (author)
  • Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.Univ Coll London Hosp NHS Fdn Trust, Natl Hosp Neurol & Neurosurg, Div Neuropathol, Queen Sq, London, England. (creator_code:org_t)

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  • In:Nature Communications: Springer Nature12:12041-1723

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