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Comparative epigene...
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Vinel, ClaireQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
(author)
Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-10-21
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Springer Nature,2021
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-458802
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-458802URI
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https://doi.org/10.1038/s41467-021-26297-6DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Epigenetic mechanisms which play an essential role in normal developmental processes, such as self-renewal and fate specification of neural stem cells (NSC) are also responsible for some of the changes in the glioblastoma (GBM) genome. Here we develop a strategy to compare the epigenetic and transcriptional make-up of primary GBM cells (GIC) with patient-matched expanded potential stem cell (EPSC)-derived NSC (iNSC). Using a comparative analysis of the transcriptome of syngeneic GIC/iNSC pairs, we identify a glycosaminoglycan (GAG)-mediated mechanism of recruitment of regulatory T cells (Tregs) in GBM. Integrated analysis of the transcriptome and DNA methylome of GBM cells identifies druggable target genes and patient-specific prediction of drug response in primary GIC cultures, which is validated in 3D and in vivo models. Taken together, we provide a proof of principle that this experimental pipeline has the potential to identify patient-specific disease mechanisms and druggable targets in GBM. The identification of patient-specific disease mechanisms and druggable targets is crucial for precision medicine in glioblastoma. Here, the authors show that comparing patients-matched glioma-initiating cells with neural stem cells enables the discovery of patient-specific mechanisms of disease and the identification of effective drugs
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Rosser, GabrielQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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Guglielmi, LoredanaQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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Constantinou, MyrianniQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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Pomella, NicolaQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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Zhang, XinyuQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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Boot, James R.Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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Jones, Tania A.Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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Millner, Thomas O.Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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Dumas, Anaelle A.Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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Rakyan, VardhmanQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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Rees, JeremyUniv Coll London Hosp NHS Fdn Trust, Natl Hosp Neurol & Neurosurg, Div Neuropathol, Queen Sq, London, England.
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Thompson, Jamie L.Univ Nottingham, Biodiscovery Inst, Stem Cell Glycobiol Grp, Nottingham, England.
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Vuononvirta, JuhoQueen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.
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Nadkarni, SuchitaQueen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.
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El Assan, TedaniUniv Coll London Hosp NHS Fdn Trust, Natl Hosp Neurol & Neurosurg, Div Neuropathol, Queen Sq, London, England.
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Aley, NatashaUCL Queen Sq Inst Neurol, Dept Neurodegenerat Dis, Queen Sq, London, England.
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Lin, Yung-YaoQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.;Queen Mary Univ London, Natl Bowel Res Ctr, Barts & London Sch Med & Dent, Stem Cell Lab, 2 Newark St, London, England.
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Liu, PentaoUniv Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Peoples R China.
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Nelander, SvenUppsala universitet,Neuroonkologi(Swepub:uu)svene843
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Sheer, DeniseQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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Merry, Catherine L. R.Univ Nottingham, Biodiscovery Inst, Stem Cell Glycobiol Grp, Nottingham, England.
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Marelli-Berg, FedericaQueen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.
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Brandner, SebastianUniv Coll London Hosp NHS Fdn Trust, Natl Hosp Neurol & Neurosurg, Div Neuropathol, Queen Sq, London, England.;UCL Queen Sq Inst Neurol, Dept Neurodegenerat Dis, Queen Sq, London, England.
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Marino, SilviaQueen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.
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Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England.Univ Coll London Hosp NHS Fdn Trust, Natl Hosp Neurol & Neurosurg, Div Neuropathol, Queen Sq, London, England.
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In:Nature Communications: Springer Nature12:12041-1723
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Vinel, Claire
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Rosser, Gabriel
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Guglielmi, Lored ...
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Constantinou, My ...
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Pomella, Nicola
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Zhang, Xinyu
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Boot, James R.
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Jones, Tania A.
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Millner, Thomas ...
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Dumas, Anaelle A ...
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Rakyan, Vardhman
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Rees, Jeremy
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Thompson, Jamie ...
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Vuononvirta, Juh ...
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Nadkarni, Suchit ...
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El Assan, Tedani
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Aley, Natasha
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Lin, Yung-Yao
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Liu, Pentao
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Nelander, Sven
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Sheer, Denise
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Merry, Catherine ...
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Marelli-Berg, Fe ...
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Brandner, Sebast ...
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Marino, Silvia
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