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  • Lind, LarsUppsala universitet,Klinisk epidemiologi (författare)

Key Characteristics of Cardiovascular Toxicants

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-458805
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-458805URI
  • https://doi.org/10.1289/EHP9321DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: The concept of chemical agents having properties that confer potential hazard called key characteristics (KCs) was first developed to identify carcinogenic hazards. Identification of KCs of cardiovascular (CV) toxicants could facilitate the systematic assessment of CV hazards and understanding of assay and data gaps associated with current approaches. OBJECTIVES: We sought to develop a consensus-based synthesis of scientific evidence on the KCs of chemical and nonchemical agents known to cause CV toxicity along with methods to measure them. METHODS: An expert working group was convened to discuss mechanisms associated with CV toxicity. RESULTS: The group identified 12 KCs of CV toxicants, defined as exogenous agents that adversely interfere with function of the CV system. The KCs were organized into those primarily affecting cardiac tissue (numbers 1-4 below), the vascular system (5-7), or both (8-12), as follows: 1) impairs regulation of cardiac excitability, 2) impairs cardiac contractility and relaxation, 3) induces cardiomyocyte injury and death, 4) induces proliferation of valve stroma, 5) impacts endothelial and vascular function, 6) alters hemostasis, 7) causes dyslipidemia, 8) impairs mitochondrial function, 9) modifies autonomic nervous system activity, 10) induces oxidative stress, 11) causes inflammation, and 12) alters hormone signaling. DISCUSSION: These 12 KCs can be used to help identify pharmaceuticals and environmental pollutants as CV toxicants, as well as to better understand the mechanistic underpinnings of their toxicity. For example, evidence exists that fine particulate matter [PM <= 2.5 mu m in aerodynamic diameter (PM2.5)] air pollution, arsenic, anthracycline drugs, and other exogenous chemicals possess one or more of the described KCs. In conclusion, the KCs could be used to identify potential CV toxicants and to define a set of test methods to evaluate CV toxicity in a more comprehensive and standardized manner than current approaches.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Araujo, Jesus A.UCLA, Univ Calif Angeles UCLA, David Geffen Sch Med, Div Cardiol, Los Angeles, CA USA.;UCLA, Fielding Sch Publ Hlth & Mol Biol Inst, Dept Environm Hlth Sci, Los Angeles, CA USA. (författare)
  • Barchowsky, AaronUniv Pittsburgh, Grad Sch Publ Hlth, Dept Environm & Occupat Hlth, Pittsburgh, PA USA. (författare)
  • Belcher, ScottNorth Carolina State Univ, Dept Biol Sci, Raleigh, NC USA. (författare)
  • Berridge, Brian R.Natl Inst Environm Hlth Sci, Natl Inst Hlth, Dept Hlth & Human Serv, Div Natl Toxicol Program, Res Triangle Pk, NC USA. (författare)
  • Chiamvimonvat, NipavanUniv Calif Davis, Dept Internal Med, Davis, CA 95616 USA. (författare)
  • Chiu, Weihsueh A.Texas A&M Univ, Coll Vet Med & Biomed Sci, College Pk, MD 95616 USA. (författare)
  • Cogliano, Vincent J.Calif Environm Protect Agcy EPA, Off Environm Hlth Hazard Assessment, Oakland, CA USA. (författare)
  • Elmore, SarahCalif Environm Protect Agcy EPA, Off Environm Hlth Hazard Assessment, Oakland, CA USA. (författare)
  • Farraj, Aimen K.US EPA, Ctr Publ Hlth & Environm, Publ Hlth & Integrated Toxicol Div, Res Triangle Pk, NC 27711 USA. (författare)
  • V. Gomes, AldrinUniv Calif Davis, Coll Biol Sci, Dept Neurobiol Physiol & Behav, Davis, CA 95616 USA. (författare)
  • McHale, Cliona M.Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, 5 123 Berkeley Way West, Berkeley, CA 94720 USA. (författare)
  • Meyer-Tamaki, Kathleen B.Sangamo Therapeut, Brisbane, CA USA. (författare)
  • Posnack, Nikki GillumNatl Childrens Hosp, Childrens Natl Heart Inst, Washington, DC USA.;Natl Childrens Hosp, Sheikh Zayed Inst Pediat Surg Innovat, Washington, DC USA. (författare)
  • Vargas, Hugo M.Amgen Inc, Translat Safety & Bioanalyt Sci, Thousand Oaks, CA 91320 USA. (författare)
  • Yang, XiFood & Drug Adm, Ctr Drug Evaluat & Res, Off Cardiol Hematol Endocrinol & Nephrol, Div Pharmacol & Toxicol, Silver Spring, MD USA. (författare)
  • Zeise, LaurenCalif Environm Protect Agcy EPA, Off Environm Hlth Hazard Assessment, Oakland, CA USA. (författare)
  • Zhou, ChangchengUniv Calif Riverside, Sch Med, Div Biomed Sci, Riverside, CA 92521 USA. (författare)
  • Smith, Martyn T.Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, 5 123 Berkeley Way West, Berkeley, CA 94720 USA. (författare)
  • Uppsala universitetKlinisk epidemiologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Environmental Health Perspectives: US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE129:90091-67651552-9924

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