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Liquid Metal Micros...
Liquid Metal Microscale Deposition enabled High Resolution and Density Epidermal Microheater for Localized Ectopic Expression in Drosophila
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- Wang, Bei (författare)
- Uppsala universitet,Mikrosystemteknik
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- Gao, Junjun (författare)
- Department of Medical Genetics School of Basic Medicine Tongji Medical College Huazhong University of Science and Technology Wuhan 430074 P. R. China
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- Jiang, Jiajun (författare)
- State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and Technology Wuhan 430074 P. R. China
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- Hu, Zenghui (författare)
- State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and Technology Wuhan 430074 P. R. China
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- Hjort, Klas, 1964- (författare)
- Uppsala universitet,Mikrosystemteknik
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- Guo, Zheng (författare)
- Department of Medical Genetics School of Basic Medicine Tongji Medical College Huazhong University of Science and Technology Wuhan 430074 P. R. China
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- Wu, Zhigang (författare)
- State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and Technology Wuhan 430074 P. R. China
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(creator_code:org_t)
- 2021-10-05
- 2022
- Engelska.
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Ingår i: Advanced Materials Technologies. - : John Wiley & Sons. - 2365-709X. ; 7:3, s. 2100903-
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Localized ectopic expression of enteroendocrine cells in fruit flies provides a convenient model for studying human intestinal diseases, e.g., inflammatory bowel disease, that need urgent attention. Due to its noninvasive feature, thermal activating ectopic expression is an excellent option, but it demands local heating of the tiny and delicate live flies’ abdomen (≈1 × 1 mm2) without blocking their breath, instead of global heating of the whole body. This work proposes a thin, high-resolution, and density liquid metal (LM) microheater with gas permeability and sufficient compliance to provide homogenous local heating to the fly's tiny abdomen. A depositing technique is developed that can make microscale thin (5 µm), smooth (Sa = 0.8 µm), gas permeable LM film for such microheater by introducing LM micrometer/sub-micrometer particles. Collision induced LM particle merging and hence sintering is proposed to solve low conductivity due to their particular shells of micrometer/sub-micrometer particles. The deposition can conformally print on the wavy or rough surface due to the fine particle size. With a shadow mask, this microscale deposition can enable high yield and reproducible thin LM patterning with high resolution, density, and precision simultaneously. Furthermore, it is demonstrated that epidermal patches can compliantly attach onto the wrinkle skin and fingerprint. Finally, by applying such a microheater on the fly abdomen, localized ectopic expression of enteroendocrine cells is successfully demonstrated.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Materialteknik -- Metallurgi och metalliska material (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering -- Metallurgy and Metallic Materials (hsv//eng)
Nyckelord
- Industrial and Manufacturing Engineering
- Mechanics of Materials
- General Materials Science
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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