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Endocrine signals f...
Endocrine signals fine-tune daily activity patterns in Drosophila
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- Pauls, Dennis (författare)
- Univ Wurzburg, Bioctr, Theodor Boveri Inst, Neurobiol & Genet, D-97074 Wurzburg, Germany.;Univ Leipzig, Inst Biol, Dept Anim Physiol, Talstr 33, D-04103 Leipzig, Germany.
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- Selcho, Mareike (författare)
- Univ Wurzburg, Bioctr, Theodor Boveri Inst, Neurobiol & Genet, D-97074 Wurzburg, Germany.;Univ Leipzig, Inst Biol, Dept Anim Physiol, Talstr 33, D-04103 Leipzig, Germany.
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- Raederscheidt, Johanna (författare)
- Univ Wurzburg, Bioctr, Theodor Boveri Inst, Neurobiol & Genet, D-97074 Wurzburg, Germany.
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- Amatobi, Kelechi M. (författare)
- Univ Wurzburg, Bioctr, Julius von Sachs Inst, Pharmaceut Biol, Julius von Sachs Pl 2, D-97082 Wurzburg, Germany.
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- Fekete, Agnes (författare)
- Univ Wurzburg, Bioctr, Julius von Sachs Inst, Pharmaceut Biol, Julius von Sachs Pl 2, D-97082 Wurzburg, Germany.
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- Krischke, Markus (författare)
- Univ Wurzburg, Bioctr, Julius von Sachs Inst, Pharmaceut Biol, Julius von Sachs Pl 2, D-97082 Wurzburg, Germany.
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- Hermann-Luibl, Christiane (författare)
- Univ Wurzburg, Bioctr, Theodor Boveri Inst, Neurobiol & Genet, D-97074 Wurzburg, Germany.
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- Ozbek-Unal, Ayten Gizem (författare)
- Univ Wurzburg, Bioctr, Theodor Boveri Inst, Neurobiol & Genet, D-97074 Wurzburg, Germany.
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- Ehmann, Nadine (författare)
- Univ Leipzig, Inst Biol, Dept Anim Physiol, Talstr 33, D-04103 Leipzig, Germany.
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- Itskov, Pavel M. (författare)
- Uppsala universitet,Schiöth: Funktionell farmakologi,Easy Behav, Rua Sao Tome & Principe 23, P-2765282 Estoril, Portuga
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- Kittel, Robert J. (författare)
- Univ Leipzig, Inst Biol, Dept Anim Physiol, Talstr 33, D-04103 Leipzig, Germany.
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- Helfrich-Foerster, Charlotte (författare)
- Univ Wurzburg, Bioctr, Theodor Boveri Inst, Neurobiol & Genet, D-97074 Wurzburg, Germany.
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- Kuehnlein, Ronald P. (författare)
- Karl Franzens Univ Graz, Inst Mol Biosci, Humboldtstr 50, A-8010 Graz, Austria.;BioTechMed Graz, A-8010 Graz, Austria.;Karl Franzens Univ Graz, Field Excellence BioHlth, Humboldtstr 50, A-8010 Graz, Austria.
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- Mueller, Martin J. (författare)
- Univ Wurzburg, Bioctr, Julius von Sachs Inst, Pharmaceut Biol, Julius von Sachs Pl 2, D-97082 Wurzburg, Germany.
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- Wegener, Christian (författare)
- Univ Wurzburg, Bioctr, Theodor Boveri Inst, Neurobiol & Genet, D-97074 Wurzburg, Germany.
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Univ Wurzburg, Bioctr, Theodor Boveri Inst, Neurobiol & Genet, D-97074 Wurzburg, Germany;Univ Leipzig, Inst Biol, Dept Anim Physiol, Talstr 33, D-04103 Leipzig, Germany. Univ Wurzburg, Bioctr, Theodor Boveri Inst, Neurobiol & Genet, D-97074 Wurzburg, Germany. (creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Current Biology. - : Elsevier. - 0960-9822 .- 1879-0445. ; 31:18, s. 4076-
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Animals need to balance competitive behaviors to maintain internal homeostasis. The underlying mechanisms are complex but typically involve neuroendocrine signaling. Using Drosophila, we systematically manipulated signaling between energy-mobilizing endocrine cells producing adipokinetic hormone (AKH), octopaminergic neurons, and the energy-storing fat body to assess whether this neuroendocrine axis involved in starvation-induced hyperactivity also balances activity levels under ad libitum access to food. Our results suggest that AKH signals via two divergent pathways that are mutually competitive in terms of activity and rest. AKH increases activity via the octopaminergic system during the day, while it prevents high activity levels during the night by signaling to the fat body. This regulation involves feedback signaling from octopaminergic neurons to AKH-producing cells (APCs). APCs are known to integrate a multitude of metabolic and endocrine signals. Our results add a new facet to the versatile regulatory functions of APCs by showing that their output contributes to shape the daily activity pattern under ad libitum access to food.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
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Pauls, Dennis
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Selcho, Mareike
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Raederscheidt, J ...
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Amatobi, Kelechi ...
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Fekete, Agnes
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Krischke, Markus
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visa fler...
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Hermann-Luibl, C ...
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Ozbek-Unal, Ayte ...
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Ehmann, Nadine
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Itskov, Pavel M.
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Kittel, Robert J ...
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Helfrich-Foerste ...
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Kuehnlein, Ronal ...
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Mueller, Martin ...
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Wegener, Christi ...
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