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Long-term night shi...
Long-term night shift work is associated with the risk of atrial fibrillation and coronary heart disease
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- Wang, Ningjian (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
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- Sun, Ying (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
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- Zhang, Haojie (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
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- Wang, Bin (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
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- Chen, Chi (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
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- Wang, Yuying (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
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- Chen, Jie (författare)
- Chinese Univ Hong Kong, Fac Med, Dept Psychiat, Sha Tin Dist,Li Chiu Kong Family Sleep Assessment, 33 A Kung Kok St, Hong Kong 000000, Peoples R China.
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- Tan, Xiao (författare)
- Karolinska Institutet,Uppsala universitet,Schiöth: Funktionell farmakologi,Karolinska Inst, Dept Clin Neurosci, Nobels Vag 9, S-17165 Stockholm, Sweden.
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- Zhang, Jihui (författare)
- Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Mental Hlth Ctr, 123 Huifu West Rd, Guangzhou 510000, Peoples R China.
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- Xia, Fangzhen (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
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- Qi, Lu (författare)
- Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, 1440 Canal St,Suite 1724, New Orleans, LA 70112 USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, 677 Huntington Ave, Boston, MA 02115 USA.;Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.
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- Lu, Yingli (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
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Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China Chinese Univ Hong Kong, Fac Med, Dept Psychiat, Sha Tin Dist,Li Chiu Kong Family Sleep Assessment, 33 A Kung Kok St, Hong Kong 000000, Peoples R China. (creator_code:org_t)
- 2021-08-10
- 2021
- Engelska.
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Ingår i: European Heart Journal. - : Oxford University Press. - 0195-668X .- 1522-9645. ; 42:40, s. 4180-
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- AimsThe aim of this study was to test whether current and past night shift work was associated with incident atrial fibrillation (AF) and whether this association was modified by genetic vulnerability. Its associations with coronary heart disease (CHD), stroke, and heart failure (HF) were measured as a secondary aim.Methods and resultsThis cohort study included 283657 participants in paid employment or self-employed without AF and 276009 participants free of CHD, stroke, and HF at baseline in the UK Biobank. Current and lifetime night shift work information was obtained. Cox proportional hazard models were used. Weighted genetic risk score for AF was calculated. During a median follow-up of 10.4years, 5777 incident AF cases were documented. From 'day workers', 'shift but never/rarely night shifts', and 'some night shifts' to 'usual/permanent night shifts', there was a significant increasing trend in the risk of incident AF (P for trend 0.013). Usual or permanent night shifts were associated with the highest risk [hazard ratio (HR) 1.16, 95% confidence interval (CI) 1.02-1.32]. Considering a person's lifetime work schedule and compared with shift workers never working nights, participants with a duration over 10years and an average 3-8 nights/month frequency of night shift work exposure possessed higher AF risk (HR 1.18, 95% CI 0.99-1.40 and HR 1.22, 95% CI 1.02-1.45, respectively). These associations between current and lifetime night shifts and AF were not modified by genetic predisposition to AF. Usual/permanent current night shifts, >= 10years and 3-8 nights/month of lifetime night shifts were significantly associated with a higher risk of incident CHD (HR 1.22, 95% CI 1.11-1.35, HR 1.37, 95% CI 1.20-1.58 and HR 1.35, 95% CI 1.18-1.55, respectively). These associations in stroke and HF were not significant.ConclusionBoth current and lifetime night shift exposures were associated with increased AF risk, regardless of genetic AF risk. Night shift exposure also increased the risk of CHD but not stroke or HF. Whether decreasing night shift work frequency and duration might represent another avenue to improve heart health during working life and beyond warrants further study.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Night shift
- Lifestyle
- Genetic risk
- Atrial fibrillation
- Coronary heart disease
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- art (ämneskategori)
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- Av författaren/redakt...
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Wang, Ningjian
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Sun, Ying
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Zhang, Haojie
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Wang, Bin
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Chen, Chi
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Wang, Yuying
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Chen, Jie
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Tan, Xiao
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Zhang, Jihui
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Xia, Fangzhen
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Qi, Lu
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Lu, Yingli
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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European Heart J ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet