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Identification of r...
Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue
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- Niessl, Julia (author)
- Karolinska Institutet
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- Sekine, Takuya (author)
- Karolinska Inst, Ctr Infect Med, Dept Med, Stockholm, Sweden.
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- Lange, Joshua (author)
- Karolinska Inst, Ctr Infect Med, Dept Med, Stockholm, Sweden.
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- Konya, Viktoria (author)
- Karolinska Inst, Ctr Infect Med, Dept Med, Stockholm, Sweden.
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- Forkel, Marianne (author)
- Karolinska Inst, Ctr Infect Med, Dept Med, Stockholm, Sweden.;Roche Innovat Ctr, Basel, Switzerland.
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- Maric, Jovana (author)
- Karolinska Inst, Ctr Infect Med, Dept Med, Stockholm, Sweden.
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- Rao, Anna (author)
- Karolinska Inst, Ctr Infect Med, Dept Med, Stockholm, Sweden.;BioNTech SE, Mainz, Germany.
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- Mazzurana, Luca (author)
- Karolinska Inst, Ctr Infect Med, Dept Med, Stockholm, Sweden.
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- Kokkinou, Efthymia (author)
- Karolinska Inst, Ctr Infect Med, Dept Med, Stockholm, Sweden.
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- Weigel, Whitney (author)
- Karolinska Inst, Ctr Infect Med, Dept Med, Stockholm, Sweden.
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- Llewellyn-Lacey, Sian (author)
- Cardiff Univ, Univ Hosp Wales, Div Infect & Immun, Sch Med, Cardiff, Wales.
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- Hodcroft, Emma B. (author)
- Univ Basel, Biozentrum, Basel, Switzerland.;Univ Bern, ISPM, Bern, Switzerland.
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- Karlsson, Annika C. (author)
- Karolinska Institutet
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- Fehrm, Johan (author)
- Karolinska Institutet
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- Sundman, Joar (author)
- Karolinska Univ Hosp, Dept Otorhinolaryngol, Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, Stockholm, Sweden.
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- Price, David A. (author)
- Cardiff Univ, Univ Hosp Wales, Div Infect & Immun, Sch Med, Cardiff, Wales.;Cardiff Univ, Univ Hosp Wales, Syst Immun Res Inst, Sch Med, Cardiff, Wales.
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- Mjösberg, Jenny (author)
- Karolinska Institutet
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- Friberg, Danielle (author)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Buggert, Marcus (author)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Ctr Infect Med, Dept Med, Stockholm, Sweden (creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2021
- 2021
- English.
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In: Science immunology. - : American Association for the Advancement of Science (AAAS). - 2470-9468. ; 6:64
- Related links:
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Abstract
Subject headings
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- Cross-reactive CD4+ T cells that recognize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more commonly detected in the peripheral blood of unexposed individuals compared with SARS-CoV-2–reactive CD8+ T cells. However, large numbers of memory CD8+ T cells reside in tissues, feasibly harboring localized SARS-CoV-2–specific immune responses. To test this idea, we performed a comprehensive functional and phenotypic analysis of virus-specific T cells in tonsils, a major lymphoid tissue site in the upper respiratory tract, and matched peripheral blood samples obtained from children and adults before the emergence of COVID-19 (coronavirus disease 2019). We found that SARS-CoV-2–specific memory CD4+ T cells could be found at similar frequencies in the tonsils and peripheral blood in unexposed individuals, whereas functional SARS-CoV-2–specific memory CD8+ T cells were almost only detectable in the tonsils. Tonsillar SARS-CoV-2–specific memory CD8+ T cells displayed a follicular homing and tissue-resident memory phenotype, similar to tonsillar Epstein-Barr virus–specific memory CD8+ T cells, but were functionally less potent than other virus-specific memory CD8+ T cell responses. The presence of preexisting tissue-resident memory CD8+ T cells in unexposed individuals could potentially enable rapid sentinel immune responses against SARS-CoV-2.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Niessl, Julia
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Sekine, Takuya
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Lange, Joshua
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Konya, Viktoria
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Forkel, Marianne
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Maric, Jovana
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show more...
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Rao, Anna
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Mazzurana, Luca
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Kokkinou, Efthym ...
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Weigel, Whitney
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Llewellyn-Lacey, ...
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Hodcroft, Emma B ...
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Karlsson, Annika ...
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Fehrm, Johan
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Sundman, Joar
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Price, David A.
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Mjösberg, Jenny
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Friberg, Daniell ...
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Buggert, Marcus
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Science immunolo ...
- By the university
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Uppsala University
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Karolinska Institutet