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Allogeneic Transpla...
Allogeneic Transplantation to Treat Therapy-Related Myelodysplastic Syndrome and Acute Myelogenous Leukemia in Adults
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- Metheny, Leland (författare)
- Univ Hosp Cleveland Med Ctr, Seidman Canc Ctr, 11100 Euclid Ave, Cleveland, OH 44122 USA.
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- Callander, Natalie S. (författare)
- Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA.,Dokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan.
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- Hall, Aric C. (författare)
- Univ Wisconsin Hosp & Clin, Madison, WI 53792 USA.
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visa fler...
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- Zhang, Mei-Jei (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA.
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- Bo-Subait, Khalid (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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- Wang, Hai-Lin (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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- Agrawal, Vaibhav (författare)
- Stanford Univ, Sch Med, Dept Med, Div Blood & Marrow Transplantat, Stanford, CA 94305 USA.
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- Samer Al-Homsi, A. (författare)
- New York Univ Langone Hlth, New York, NY USA.,Columbia Univ, Dept Med, Irving Med Ctr, Bone Marrow Transplant & Cell Therapy Program, New York, NY USA.
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- Assal, Amer (författare)
- Columbia Univ, Dept Med, Irving Med Ctr, Bone Marrow Transplant & Cell Therapy Program, New York, NY USA.,Mayo Clin, Blood & Marrow Transplantat Program, Div Hematol Oncol, Jacksonville, FL 32224 USA.;Univ Calgary, Calgary, AB, Canada.,Univ Maryland, Greenebaum Comprehens Canc Ctr, Dept Med, Blood & Marrow Transplantat Program,Div Hematol O, Baltimore, MD 21201 USA.
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- Bacher, Ulrike (författare)
- Univ Bern, Univ Hosp Bern, Inselspital, Dept Hematol, Bern, Switzerland.
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- Beitinjaneh, Amer (författare)
- Univ Miami, Div Transplantat & Cellular Therapy, Miami, FL USA.
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- Bejanyan, Nelli (författare)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Minneapolis, MN USA.
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- Bhatt, Vijaya Raj (författare)
- Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA.
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- Bredeson, Chris (författare)
- Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada.;Ottawa Hosp Res Inst, Ottawa, ON, Canada.
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- Byrne, Michael (författare)
- Vanderbilt Univ, Med Ctr, Nashville, TN USA.
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- Cairo, Mitchell (författare)
- New York Med Coll, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, Valhalla, NY 10595 USA.
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- Cerny, Jan (författare)
- Univ Massachusetts, Med Ctr, Dept Med, Div Hematol Oncol, Worcester, MA USA.
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- DeFilipp, Zachariah (författare)
- Massachusetts Gen Hosp, Hematopoiet Cell Transplant & Cellular Therapy Pr, Boston, MA 02114 USA.
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- Diaz Perez, Miguel Angel (författare)
- Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain.
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- Freytes, César O. (författare)
- Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
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- Ganguly, Siddhartha (författare)
- Univ Kansas Hlth Syst, Div Hematol Malignancy & Cellular Therapeut, Kansas City, KS USA.
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- Grunwald, Michael R. (författare)
- Atrium Hlth, Levine Canc Inst, Dept Hematol Oncol & Blood Disorders, Charlotte, NC USA.
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- Hashmi, Shahrukh (författare)
- Mayo Clin, Dept Internal Med, Rochester, MN USA.;Sheikh Shakhbout Med City, Dept Med, Abu Dhavi, U Arab Emirates.
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- Hildebrandt, Gerhard C. (författare)
- Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.
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- Inamoto, Yoshihiro (författare)
- Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan.
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- Kanakry, Christopher G. (författare)
- NCI, Expt Transplantat & Immunotherapy Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
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- Kharfan-Dabaja, Mohamed A. (författare)
- Mayo Clin, Blood & Marrow Transplantat Program, Div Hematol Oncol, Jacksonville, FL 32224 USA.;Univ Calgary, Calgary, AB, Canada.
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- Lazarus, Hillard M. (författare)
- Case Western Reserve Univ, Univ Hosp Cleveland Med Ctr, Cleveland, OH 44106 USA.
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- Lee, Jong Wook (författare)
- Catholic Univ Korea, Seoul St Marys Hosp, Div Hematol, Seoul, South Korea.
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- Nathan, Sunita (författare)
- Rush Univ, Med Ctr, Sect Bone Marrow Transplant & Cell Therapy, Chicago, IL 60612 USA.
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- Nishihori, Taiga (författare)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Minneapolis, MN USA.
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- Olsson, Richard F. (författare)
- Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden
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- Ringdén, Olov (författare)
- Karolinska Institutet,Karolinska Inst, Translat Cell Therapy Grp, CLINTEC Clin Sci Intervent & Technol, Stockholm, Sweden.
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- Rizzieri, David (författare)
- Duke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA.
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- Savani, Bipin N. (författare)
- Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.
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Savoie, Mary Lynn (författare)
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- Seo, Sachiko (författare)
- Dokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan.,NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA.
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- van der Poel, Marjolein (författare)
- Maastricht Univ, Med Ctr, Maastricht, Netherlands.
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- Verdonck, Leo F. (författare)
- Isala Clin, Dept Hematol Oncol, Zwolle, Netherlands.
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- Wagner, John L. (författare)
- Thomas Jefferson Univ, Dept Med Oncol, Philadelphia, PA 19107 USA.
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- Yared, Jean A. (författare)
- Univ Maryland, Greenebaum Comprehens Canc Ctr, Dept Med, Blood & Marrow Transplantat Program,Div Hematol O, Baltimore, MD 21201 USA.
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- Hourigan, Christopher S. (författare)
- NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA.
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- Kebriaei, Partow (författare)
- Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Div Canc Med, Houston, TX 77030 USA.
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- Litzow, Mark (författare)
- Mayo Clin Rochester, Div Hematol, Rochester, MN USA.;Mayo Clin Rochester, Transplant Ctr, Rochester, MN USA.
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- Sandmaier, Brenda M. (författare)
- Univ Washington, Div Med Oncol, Seattle, WA 98195 USA.;Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.
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- Saber, Wael (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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- Weisdorf, Daniel (författare)
- Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA.
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- de Lima, Marcos (författare)
- Univ Hosp Case Med Ctr, Seidman Canc Ctr, Dept Med, Cleveland, OH USA.
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Freytes, EO (författare)
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Univ Hosp Cleveland Med Ctr, Seidman Canc Ctr, 11100 Euclid Ave, Cleveland, OH 44122 USA Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA. (creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Transplantation and Cellular Therapy. - : Elsevier. - 2666-6375 .- 2666-6367. ; 27:11, s. 923.e1-923.e12
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Patients who develop therapy-related myeloid neoplasm, either myelodysplastic syndrome (t-MDS) or acute myelogenous leukemia (t-AML), have a poor prognosis. An earlier Center for International Blood and Marrow Transplant Research (CIBMTR) analysis of 868 allogeneic hematopoietic cell transplantations (allo-HCTs) performed between 1990 and 2004 showed a 5-year overall survival (OS) and disease-free survival (DFS) of 22% and 21%, respectively. Modern supportive care, graft-versus-host disease prophylaxis, and reduced-intensity conditioning (RIC) regimens have led to improved outcomes. Therefore, the CIBMTR analyzed 1531 allo-HCTs performed in adults with t-MDS (n = 759) or t-AML (n = 772) between and 2000 and 2014. The median age was 59 years (range, 18 to 74 years) for the patients with t-MDS and 52 years (range, 18 to 77 years) for those with tAML. Twenty-four percent of patients with t-MDS and 11% of those with t-AML had undergone a previous autologous (auto-) HCT. A myeloablative conditioning (MAC) regimen was used in 49% of patients with t-MDS and 61% of patients with t-AML. Nonrelapse mortality at 5 years was 34% (95% confidence interval [CI], 30% to 37%) for patients with t-MDS and 34% (95% CI, 30% to 37%) for those with t-AML. Relapse rates at 5 years in the 2 groups were 46% (95% CI, 43% to 50%) and 43% (95% CI, 40% to 47%). Five-year OS and DFS were 27% (95% CI, 23% to 31%) and 19% (95% CI, 16% to 23%), respectively, for patients with t-MDS and 25% (95% CI, 22% to 28%) and 23% (95% CI, 20% to 26%), respectively, for those with t-AML. In multivariate analysis, OS and DFS were significantly better in young patients with low-risk t-MDS and those with t-AML undergoing HCT with MAC while in first complete remission, but worse for those with previous auto-HCT, higher-risk cytogenetics or Revised International Prognostic Scoring System score, and a partially matched unrelated donor. Relapse remains the major cause of treatment failure, with little improvement seen over the past 2 decades. These data mandate caution when recommending allo-HCT in these conditions and indicate the need for more effective antineoplastic approaches before and after allo-HCT.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Allogeneic transplantation
- Acute myelogenous leukemia
- Myelodysplasia
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Metheny, Leland
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Callander, Natal ...
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Hall, Aric C.
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Zhang, Mei-Jei
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Bo-Subait, Khali ...
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Wang, Hai-Lin
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visa fler...
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Agrawal, Vaibhav
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Samer Al-Homsi, ...
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Assal, Amer
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Bacher, Ulrike
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Beitinjaneh, Ame ...
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Bejanyan, Nelli
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Bhatt, Vijaya Ra ...
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Bredeson, Chris
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Byrne, Michael
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Cairo, Mitchell
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Cerny, Jan
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DeFilipp, Zachar ...
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Diaz Perez, Migu ...
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Freytes, César O ...
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Ganguly, Siddhar ...
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Grunwald, Michae ...
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Hashmi, Shahrukh
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Hildebrandt, Ger ...
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Inamoto, Yoshihi ...
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Kanakry, Christo ...
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Kharfan-Dabaja, ...
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Lazarus, Hillard ...
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Lee, Jong Wook
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Nathan, Sunita
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Nishihori, Taiga
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Olsson, Richard ...
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Ringdén, Olov
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Rizzieri, David
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Savani, Bipin N.
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Savoie, Mary Lyn ...
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Seo, Sachiko
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van der Poel, Ma ...
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Verdonck, Leo F.
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Wagner, John L.
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Yared, Jean A.
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Hourigan, Christ ...
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Kebriaei, Partow
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Litzow, Mark
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Sandmaier, Brend ...
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Saber, Wael
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Weisdorf, Daniel
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de Lima, Marcos
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Freytes, EO
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Uppsala universitet
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Karolinska Institutet