Intracranial pressure dynamics and cerebral vasomotor reactivity in community-acquired bacterial meningitis during neurointensive care

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Svedung-Wettervik, TeodorUppsala universitet,Enblad: Neurokirurgi (författare)

Intracranial pressure dynamics and cerebral vasomotor reactivity in community-acquired bacterial meningitis during neurointensive care

Artikel/kapitelEngelska2022

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American Association of Neurological Surgeons,2022
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LIBRIS-ID:oai:DiVA.org:uu-460155
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-460155URI
https://doi.org/10.3171/2021.2.JNS2148DOI

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Språk:engelska
Sammanfattning på:engelska

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OBJECTIVE: Community-acquired bacterial meningitis (CABM) is a severe condition associated with high mortality. In this study the first aim was to evaluate the incidence of intracranial pressure (ICP) insults and disturbances in cerebral vasomotor reactivity and the second aim was to evaluate the management and clinical outcome of CABM patients treated in the neurointensive care unit (NICU).METHODS: CABM patients who were treated in the NICU of Uppsala University Hospital, Sweden, during 2008–2020 were included in the study. Data on demographics, admission variables, treatment, ICP dynamics, vasomotor reactivity, and short-term clinical outcome were evaluated in these patients.RESULTS: Of 97 CABM patients, 81 (84%) received ICP monitoring, of whom 22% had ICP > 20 mm Hg during 5% or more of the monitoring time on day 1, which decreased to 9% on day 3. For those patients with ICP monitoring, 46% required CSF drainage, but last-tier ICP treatment, including thiopental (4%) and decompressive craniectomy (1%), was rare. Cerebral vasomotor reactivity was disturbed, with a mean pressure reactivity index (PRx) above 0.2 in 45% of the patients on day 1, and remained high for the first 3 days. In total, 81 (84%) patients had a favorable outcome (Glasgow Coma Scale motor score [GCS M] 6) at discharge, 9 (9%) patients had an unfavorable outcome (GCS M < 6) at discharge, and 7 (7%) patients died in the NICU. Those with favorable outcome had significantly better cerebral vasomotor reactivity (lower PRx) than the two other outcome groups (p < 0.01).CONCLUSIONS: Intracranial hypertension was frequent following severe CABM and CSF drainage was often sufficient to control ICP. Cerebral vasomotor reactivity was commonly disturbed and associated with poor outcome. Clinical outcome was slightly better than in earlier studies.

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Howells, TimothyUppsala universitet,Enblad: Neurokirurgi(Swepub:uu)timho266 (författare)
Ljunghill Hedberg, AnnaUppsala universitet,Infektionssjukdomar(Swepub:uu)annlj496 (författare)
Lewén, Anders,1965-Uppsala universitet,Enblad: Neurokirurgi(Swepub:uu)andelewe (författare)
Enblad, PerUppsala universitet,Enblad: Neurokirurgi(Swepub:uu)perenbla (författare)
Uppsala universitetEnblad: Neurokirurgi (creator_code:org_t)

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Ingår i:Journal of Neurosurgery: American Association of Neurological Surgeons136:3, s. 831-8390022-30851933-0693

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Av författaren/redakt...: Svedung-Wettervi ...; Howells, Timothy; Ljunghill Hedber ...; Lewén, Anders, 1 ...; Enblad, Per

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Av lärosätet: Uppsala universitet

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