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Alcohol consumption...
Alcohol consumption in relation to cardiovascular diseases and mortality : a systematic review of Mendelian randomization studies
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van de Luitgaarden, Inge A T (författare)
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van Oort, Sabine (författare)
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Bouman, Emma J (författare)
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Schoonmade, Linda J (författare)
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Schrieks, Ilse C (författare)
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Grobbee, Diederick E (författare)
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van der Schouw, Yvonne T (författare)
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- Larsson, Susanna C. (författare)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
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Burgess, Stephen (författare)
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van Ballegooijen, Adriana J (författare)
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Onland-Moret, N Charlotte (författare)
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Beulens, Joline W J (författare)
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(creator_code:org_t)
- 2021-08-22
- 2022
- Engelska.
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Ingår i: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 37:7, s. 655-669
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The causal effects of alcohol-in-moderation on cardiometabolic health are continuously debated. Mendelian randomization (MR) is an established method to address causal questions in observational studies. We performed a systematic review of the current evidence from MR studies on the association between alcohol consumption and cardiometabolic diseases, all-cause mortality and cardiovascular risk factors. We performed a systematic search of the literature, including search terms on type of design and exposure. We assessed methodological quality based on key elements of the MR design: use of a full instrumental variable analysis and validation of the three key MR assumptions. We additionally looked at exploration of non-linearity. We reported the direction of the studied associations. Our search yielded 24 studies that were eligible for inclusion. A full instrumental variable analysis was performed in 17 studies (71%) and 13 out of 24 studies (54%) validated all three key assumptions. Five studies (21%) assessed potential non-linearity. In general, null associations were reported for genetically predicted alcohol consumption with the primary outcomes cardiovascular disease (67%) and diabetes (75%), while the only study on all-cause mortality reported a detrimental association. Considering the heterogeneity in methodological quality of the included MR studies, it is not yet possible to draw conclusions on the causal role of moderate alcohol consumption on cardiometabolic health. As MR is a rapidly evolving field, we expect that future MR studies, especially with recent developments regarding instrument selection and non-linearity methodology, will further substantiate this discussion.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Alcohol consumption
- Cardiovascular disease
- Cardiovascular risk factors
- Diabetes
- Mendelian randomization
- Mortality
- Systematic review
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van de Luitgaard ...
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van Oort, Sabine
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Bouman, Emma J
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Schoonmade, Lind ...
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Schrieks, Ilse C
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Grobbee, Diederi ...
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visa fler...
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van der Schouw, ...
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Larsson, Susanna ...
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Burgess, Stephen
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van Ballegooijen ...
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Onland-Moret, N ...
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Beulens, Joline ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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European Journal ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet