Genetically predicted circulating vitamin C in relation to cardiovascular disease.

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Sökning: WFRF:(Zheng Ju Sheng) > Genetically predict...

Yuan, ShuaiKarolinska Institutet (författare)

Genetically predicted circulating vitamin C in relation to cardiovascular disease.

Artikel/kapitelEngelska2021

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2021-05-31
Oxford University Press,2021
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LIBRIS-ID:oai:DiVA.org:uu-460403
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-460403URI
https://doi.org/10.1093/eurjpc/zwab081DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:148654094URI

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Språk:engelska
Sammanfattning på:engelska

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AIM: We conducted a two-sample Mendelian randomization (MR) study to assess the associations of genetically predicted circulating vitamin C levels with cardiovascular diseases (CVDs).METHODS AND RESULTS: Ten lead single-nucleotide polymorphisms associated with plasma vitamin C levels at the genome-wide significance level were used as instrumental variables. Summary-level data for 15 CVDs were obtained from corresponding genetic consortia, the UK Biobank study, and the FinnGen consortium. The inverse-variance-weighted method was the primary analysis method, supplemented by the weighted median and MR-Egger methods. Estimates for each CVD from different sources were combined. Genetically predicted vitamin C levels were not associated with any CVD after accounting for multiple testing. However, there were suggestive associations of higher genetically predicted vitamin C levels (per 1 standard deviation increase) with lower risk of cardioembolic stroke [odds ratio, 0.79; 95% confidence interval (CI), 0.64, 0.99; P = 0.038] and higher risk of atrial fibrillation (odds ratio, 1.09; 95% CI, 1.00, 1.18; P = 0.049) in the inverse-variance-weighted method and with lower risk of peripheral artery disease (odds ratio, 0.76, 95% CI, 0.62, 0.93; P = 0.009) in the weighted median method.CONCLUSION: We found limited evidence with MR techniques for an overall protective role of vitamin C in the primary prevention of CVD. The associations of vitamin C levels with cardioembolic stroke, atrial fibrillation, and peripheral artery disease need further study.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Cardiovascular disease
Mendelian randomization
Vitamin C

Biuppslag (personer, institutioner, konferenser, titlar ...)

Zheng, Ju-Sheng (författare)
Mason, Amy M (författare)
Burgess, Stephen (författare)
Larsson, Susanna C.Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Sweden.(Swepub:uu)susla720 (författare)
Karolinska InstitutetMedicinsk epidemiologi (creator_code:org_t)

Sammanhörande titlar

Ingår i:European Journal of Preventive Cardiology: Oxford University Press28:16, s. 1829-18372047-48732047-4881

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Av författaren/redakt...: Yuan, Shuai; Zheng, Ju-Sheng; Mason, Amy M; Burgess, Stephen; Larsson, Susanna ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

Artiklar i publikationen: European Journal ...

Av lärosätet: Uppsala universitet; Karolinska Institutet

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