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Extent of Lymphaden...
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Gottlieb-Vedi, EivindKarolinska Institutet
(författare)
Extent of Lymphadenectomy and Long-Term Survival in Esophageal Cancer
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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Wolters Kluwer,2023
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-460819
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-460819URI
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https://doi.org/10.1097/SLA.0000000000005028DOI
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https://lup.lub.lu.se/record/bca605e0-6a2e-454a-b63d-f5370f01b59aURI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-179522URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:152050709URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding: Swedish Research Council [201900209]; Swedish Cancer Society [180684]
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Objective: To examine the hypothesis that survival in esophageal cancer increases with more removed lymph nodes during esophagectomy up to a plateau, after which it levels out or even decreases with further lymphadenectomy.Summary of Background Data: There is uncertainty regarding the ideal extent of lymphadenectomy during esophagectomy to optimize long-term survival in esophageal cancer.Methods: This population-based cohort study included almost every patient who underwent esophagectomy for esophageal cancer in Sweden or Finland in 2000-2016 with follow-up through 2019. Degree of lymphadenectomy, divided into deciles, was analyzed in relation to all-cause 5-year mortality. Multivariable Cox regression provided hazard ratios (HR) with 95% confidence intervals (95% CI) adjusted for all established prognostic factors.Results: Among 2,306 patients, the 2nd (4-8 nodes), 7th (21-24 nodes) and 8th decile (25-30 nodes) of lymphadenectomy showed the lowest all-cause 5-year mortality compared to the 1st decile (HR = 0.77, 95% CI 0.61-0.97, HR = 0.76, 95% CI 0.59-0.99, and HR = 0.73, 95% CI 0.57-0.93, respectively). In stratified analyses, the survival benefit was greatest in decile 7 for patients with pathological T-stage T3/T4 (HR = 0.56, 95% CI 0.40-0.78), although it was statistically improved in all deciles except decile 10. For patients without neoadjuvant chemotherapy, survival was greatest in decile 7 (HR = 0.60, 95% CI 0.41-0.86), although survival was also statistically significantly improved in deciles 2, 6, and 8.Conclusion: Survival in esophageal cancer was not improved by extensive lymphadenectomy, but resection of a moderate number (20-30) of nodes was prognostically beneficial for patients with advanced T-stages (T3/T4) and those not receiving neoadjuvant therapy.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kauppila, Joonas HKarolinska Institutet
(författare)
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Mattsson, FredrikKarolinska Institute,Upper Gastrointestinal Surgery, Department of Molecular medicine and Surgery, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden(Swepub:lu)fr3821ma
(författare)
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Hedberg, Jakob,1972-Uppsala University,Uppsala universitet,Institutionen för kirurgiska vetenskaper,Department of Surgical Sciences, Uppsala University, Sweden(Swepub:uu)jakhe890
(författare)
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Johansson, JanKarolinska Institutet,Lund University,Lunds universitet,Upper Gastrointestinal Surgery,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Department of Surgery, Skåne University Hospital, Lund; Faculty of Medicine, Clinical Sciences, Lund University, Sweden(Swepub:lu)kir-jjo
(författare)
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Edholm, DavidLinköpings universitet,Linköping University,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)daved38
(författare)
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Lagergren, PernillaKarolinska Institutet
(författare)
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Nilsson, MagnusKarolinska Institutet
(författare)
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Lagergren, JesperUpper Gastrointestinal Surgery, Department of Molecular medicine and Surgery, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden; School of Cancer and Pharmaceutical Sciences, King's College London, and Guy's and St Thomas’ NHS Foundation Trust, London, UK.
(författare)
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Karolinska InstituteKarolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Annals of Surgery: Wolters Kluwer277:3, s. 429-4360003-49321528-1140
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