1843 – Depression in the peripartum period in association with salivary cortisol levels

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: L773:0924 9338 OR L773:1778 3585 > (2010-2014) > 1843 – Depression i...

Details
MARC

Iliadis, Stavros I,1983-Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning (author)

1843 – Depression in the peripartum period in association with salivary cortisol levels

Article/chapterEnglish2013

Publisher, publication year, extent ...

Elsevier,2013
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-461393
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-461393URI
https://doi.org/10.1016/s0924-9338(13)76807-xDOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:vet swepub-contenttype
Subject category:art swepub-publicationtype

Notes

IntroductionThe Hypothalamic-Pituitary-Adrenal Axis (HPA axis) has been implicated in the pathogenesis of many affective disorders. Peripartum depression is a condition that includes depressive episodes occurring during pregnancy and the postpartum period. During uncomplicated pregnancy, mean cortisol levels rise substantially, mostly due to high levels of corticotropin releasing hormone produced by the placenta (p-CRH). The latter also suppresses hypothalamic CRH, leading to hypo-cortisolemia after partus. Cortisol concentration is usually normalised within two weeks after delivery. Failure of the above process results in continuing hypo-cortisolemia, which might increase susceptibility to PPD.Objectives/aimsThe current study aims to investigate the relationship between evening salivary cortisol levels and depression during the peripartum period.MethodsThree hundred and forty six pregnant women were asked to participate in the study. They completed the Edinburgh Postnatal Depression Scale (EPDS) and the Spielberger State-Trait Anxiety Inventory-State version (STAI-S) at the 36th week of pregnancy and the 6th week after delivery. At both times, study subjects were also asked to collect evening salivary samples by using a mail-delivered kit. Moreover, they were interviewed at the 36th week of pregnancy using the Mini International Neuropsychiatric Interview (MINI).ResultsPreliminary results indicate significantly higher evening salivary cortisol levels in depressed women during late pregnancy compared to healthy controls. No difference in cortisol levels was found between women with postpartum depression and healthy controls.ConclusionsOur study results support the hypothesis that depression during pregnancy resembles melancholic depression characterized by hyperactivity of the HPA-axis and hyper-cortisolemia.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
Psychiatry and Mental health
Psychiatry
Psykiatri

Added entries (persons, corporate bodies, meetings, titles ...)

Hellgren, Charlotte,1985-Uppsala universitet,Reproduktiv hälsa(Swepub:uu)chahe643 (author)
Sylvén, Sara M,1982-Uppsala universitet,Institutionen för neurovetenskap,Obstetrisk och reproduktiv hälsoforskning(Swepub:uu)sarsy916 (author)
Papadopoulos, Fotios,1976-Uppsala universitet,Institutionen för medicinska vetenskaper,Cervenka: Psykiatri(Swepub:uu)fotpa105 (author)
Sundström Poromaa, Inger,1964-Uppsala universitet,Reproduktiv hälsa(Swepub:uu)inspo702 (author)
Skalkidou, A.,1977-Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning(Swepub:uu)alksk607 (author)
Uppsala universitetObstetrisk och reproduktiv hälsoforskning (creator_code:org_t)

Related titles

In:European psychiatry: Elsevier28:Supplement 1, s. 1-10924-93381778-3585

Internet link

Find in a library

European psychiatry (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Iliadis, Stavros ...; Hellgren, Charlo ...; Sylvén, Sara M, ...; Papadopoulos, Fo ...; Sundström Poroma ...; Skalkidou, A., 1 ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

Articles in the publication: European psychia ...

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se