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Combined expression...
Combined expression of HOXA11 and CD10 identifies endometriosis versus normal tissue and tumors
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- Bergman-Larsson, Julia (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Gustafsson, Sofie (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Méar, Loren (author)
- Uppsala universitet,Klinisk och experimentell patologi
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- Huvila, Jutta (author)
- Univ Turku, Turku Univ Hosp, Dept Pathol & Forens Med, Turku, Finland.
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- Tolf, Anna (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Olovsson, Matts, 1958- (author)
- Uppsala universitet,Reproduktionsbiologi
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- Pontén, Fredrik (author)
- Uppsala universitet,Klinisk och experimentell patologi
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- Edqvist, Per-Henrik D (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Dag Hammarskjolds Vag 20, SE-75185 Uppsala, Sweden.
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Annals of Diagnostic Pathology. - : Elsevier. - 1092-9134 .- 1532-8198. ; 56
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Abstract
Subject headings
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- The gold standard for diagnosing endometriosis is by laparoscopic visual demonstration of ectopic endometrial lesions outside the uterus, preferably verified by biopsy and microscopical examination. Molecular markers to facilitate the microscopical diagnosis of endometriosis and for distinguishing endometriosis from other benign and malignant lesions are lacking. Our aim was to test and validate an immunohistochemical antibody panel for improved diagnostic accuracy of endometriosis. Both CD10 and HOXA11 have been implicated in regulation of endometrial homeostasis. Here we have analyzed the expression pattern of these two proteins using immunohistochemistry on human tissues in a tissue microarray format. CD10 and HOXA11 expression in endometriosis lesions were compared to expression patterns in a range of normal tissues and in primary- and metastatic lesions of endometrial-, cervical- and ovarian cancer. HOXA11 and CD10 were expressed in 98% and 91% of endometriosis lesions and the combined double-positive expression profile of both HOXA11 and CD10 was highly sensitive for ectopic endometrial tissue (90%). The specificity and sensitivity for this double-positive signature in endometriosis was significantly different from all investigated tissues, cancers and metastases except normal, eutopic endometrial- and cervical mucosa. The combination of HOXA11 and CD10 expression profiles provides a useful tool to identify ectopic endometrial tissue and for distinguishing endometriosis from various types of gynecological malignancies and metastases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Endometriosis
- Endometrium
- Immunohistochemistry
- Gynecological malignancies
- Differential diagnostics
Publication and Content Type
- ref (subject category)
- art (subject category)
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