Sökning: WFRF:(Muhammad Ghulam) >
A UPLC-DAD-Based Bi...
-
Tehreem, SyedaUniv Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan.
(författare)
A UPLC-DAD-Based Bio-Screening Assay for the Evaluation of the Angiotensin Converting Enzyme Inhibitory Potential of Plant Extracts and Compounds : Pyrroquinazoline Alkaloids from Adhatoda vasica as a Case Study
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
-
2021-11-18
-
MDPI,2021
-
electronicrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-461972
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-461972URI
-
https://doi.org/10.3390/molecules26226971DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Angiotensin converting enzyme (ACE) plays a crucial role in regulating blood pressure in the human body. Identification of potential ACE inhibitors from medicinal plants supported the idea of repurposing these medicinal plants against hypertension. A method based on ultra-performance liquid chromatography (UPLC) coupled with a diode array detector (DAD) was used for the rapid screening of plant extracts and purified compounds to determine their ACE inhibitory activity. Hippuryl-histidiyl-leucine (HHL) was used as a substrate, which is converted into hippuric acid (HA) by the action of ACE. A calibration curve of the substrate HHL was developed with the linear regression 0.999. The limits of detection and quantification of this method were found to be 0.134 and 0.4061 mM, respectively. Different parameters of ACE inhibitory assay were optimized, including concentration, incubation time and temperature. The ACE inhibition potential of Adhatoda vasica (methanolic-aqueous extract) and its isolated pyrroquinazoline alkaloids, vasicinol (1), vasicine (2) and vasicinone (3) was evaluated. Compounds 1-3 were characterized by various spectroscopic techniques. The IC50 values of vasicinol (1), vasicine (2) and vasicinone (3) were found to be 6.45, 2.60 and 13.49 mM, respectively. Molecular docking studies of compounds 1-3 were also performed. Among these compounds, vasicinol (1) binds as effectively as captopril, a standard drug of ACE inhibition.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Rahman, SaeedurUniv Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan.
(författare)
-
Bhatti, Muhammad SalmanUniv Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan.
(författare)
-
Uddin, ReazUniv Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.
(författare)
-
Khan, Muhammad NomanUniv Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan.
(författare)
-
Tauseef, SabaUniv Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.
(författare)
-
El-Seedi, HeshamUppsala universitet,Institutionen för farmaceutisk biovetenskap,Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China.,Farmakognosi(Swepub:uu)heels173
(författare)
-
Bin Muhsinah, AbdullatifKing Khalid Univ, Coll Pharm, Dept Pharmacognosy, Abha 62529, Saudi Arabia.
(författare)
-
Uddin, JalalKing Khalid Univ, Coll Pharm, Dept Pharmaceut Chem, Abha 62529, Saudi Arabia.
(författare)
-
Musharraf, Syed GhulamUniv Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan.;Univ Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.;Southwest Med Univ, TCM Hosp, Luzhou 646000, Peoples R China.
(författare)
-
Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan.Univ Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Molecules: MDPI26:221431-51571420-3049
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Tehreem, Syeda
-
Rahman, Saeedur
-
Bhatti, Muhammad ...
-
Uddin, Reaz
-
Khan, Muhammad N ...
-
Tauseef, Saba
-
visa fler...
-
El-Seedi, Hesham
-
Bin Muhsinah, Ab ...
-
Uddin, Jalal
-
Musharraf, Syed ...
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Biologi
-
och Biokemi och mole ...
- Artiklar i publikationen
-
Molecules
- Av lärosätet
-
Uppsala universitet