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Hippocampal Transcr...
Hippocampal Transcriptome-Wide Association Study Reveals Correlations Between Impaired Glutamatergic Synapse Pathway and Age-Related Hearing Loss in BXD-Recombinant Inbred Mice
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- Deng, Tingzhi (author)
- Binzhou Med Univ, Precis Med Res Ctr, Sch Pharm, Yantai, Peoples R China.
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- Li, Jingjing (author)
- Binzhou Med Univ, Precis Med Res Ctr, Sch Pharm, Yantai, Peoples R China.;Qingdao Univ, Yantai Yuhuangding Hosp, Dept Otorhinolaryngol Head & Neck Surg, Yantai, Peoples R China.;Binzhou Med Univ, Clin Med Coll 2, Yantai, Peoples R China.
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- Liu, Jian (author)
- Shandong First Med Univ, Shandong Prov Qianfoshan Hosp, Dept Plast Surg, Affiliated Hosp 1, Jinan, Peoples R China.
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- Xu, Fuyi (author)
- Binzhou Med Univ, Precis Med Res Ctr, Sch Pharm, Yantai, Peoples R China.;Univ Tennessee, Dept Genet Genom & Informat, Hlth Sci Ctr, Memphis, TN USA.
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- Liu, Xiaoya (author)
- Binzhou Med Univ, Precis Med Res Ctr, Sch Pharm, Yantai, Peoples R China.
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- Mi, Jia (author)
- Binzhou Med Univ, Precis Med Res Ctr, Sch Pharm, Yantai, Peoples R China.
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- Bergquist, Jonas (author)
- Uppsala universitet,Analytisk kemi,Binzhou Med Univ, Precis Med Res Ctr, Sch Pharm, Yantai, Peoples R China.
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- Wang, Helen (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Yang, Chunhua (author)
- Binzhou Med Univ, Precis Med Res Ctr, Sch Pharm, Yantai, Peoples R China.
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- Lu, Lu (author)
- Univ Tennessee, Dept Genet Genom & Informat, Hlth Sci Ctr, Memphis, TN USA.
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- Song, Xicheng (author)
- Qingdao Univ, Yantai Yuhuangding Hosp, Dept Otorhinolaryngol Head & Neck Surg, Yantai, Peoples R China.
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- Yao, Cuifang (author)
- Binzhou Med Univ, Precis Med Res Ctr, Sch Pharm, Yantai, Peoples R China.
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- Tian, Geng (author)
- Binzhou Med Univ, Precis Med Res Ctr, Sch Pharm, Yantai, Peoples R China.
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- Zheng, Qing Yin (author)
- Case Western Reserve Univ, Dept Otolaryngol Head & Neck Surg, Cleveland, OH 44106 USA.
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Binzhou Med Univ, Precis Med Res Ctr, Sch Pharm, Yantai, Peoples R China Binzhou Med Univ, Precis Med Res Ctr, Sch Pharm, Yantai, Peoples R China.;Qingdao Univ, Yantai Yuhuangding Hosp, Dept Otorhinolaryngol Head & Neck Surg, Yantai, Peoples R China.;Binzhou Med Univ, Clin Med Coll 2, Yantai, Peoples R China. (creator_code:org_t)
- 2021-11-17
- 2021
- English.
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In: Frontiers in Neuroscience. - : Frontiers Media S.A.. - 1662-4548 .- 1662-453X. ; 15
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Abstract
Subject headings
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- Age-related hearing loss (ARHL) is associated with cognitive dysfunction; however, the detailed underlying mechanisms remain unclear. The aim of this study is to investigate the potential underlying mechanism with a system genetics approach. A transcriptome-wide association study was performed on aged (12-32 months old) BXD mice strains. The hippocampus gene expression was obtained from 56 BXD strains, and the hearing acuity was assessed from 54 BXD strains. Further correlation analysis identified a total of 1,435 hearing-related genes in the hippocampus (p < 0.05). Pathway analysis of these genes indicated that the impaired glutamatergic synapse pathway is involved in ARHL (p = 0.0038). Further gene co-expression analysis showed that the expression level of glutamine synthetase (Gls), which is significantly correlated with ARHL (n = 26, r = -0.46, p = 0.0193), is a crucial regulator in glutamatergic synapse pathway and associated with learning and memory behavior. In this study, we present the first systematic evaluation of hippocampus gene expression pattern associated with ARHL, learning, and memory behavior. Our results provide novel potential molecular mechanisms involved in ARHL and cognitive dysfunction association.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- hearing loss
- systems genetics
- cognitive dysfunction
- glutamine synthetase (Gls)
- gene network
- BXD mice strain
- transcriptome-wide association study (TWAS)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Deng, Tingzhi
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Li, Jingjing
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Liu, Jian
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Xu, Fuyi
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Liu, Xiaoya
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Mi, Jia
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Bergquist, Jonas
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Wang, Helen
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Yang, Chunhua
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Lu, Lu
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Song, Xicheng
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Yao, Cuifang
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Tian, Geng
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Zheng, Qing Yin
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Frontiers in Neu ...
- By the university
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Uppsala University