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Risk factors for th...
Risk factors for the delayed viral clearance in COVID‐19 patients
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- Chen, Xiaoping (author)
- Department of Infectious Diseases Zhongnan Hospital of Wuhan University Wuhan China
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- Hu MT, Wenjia (author)
- Department of Infectious Diseases Zhongnan Hospital of Wuhan University Wuhan China
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- Yang, Miao (author)
- Department of Endocrinology Zhongnan Hospital of Wuhan University Wuhan China
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- Ling, Jiaxin (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Zhang, Yongxi (author)
- Department of Infectious Diseases Zhongnan Hospital of Wuhan University Wuhan China
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- Deng, Liping (author)
- Department of Infectious Diseases Zhongnan Hospital of Wuhan University Wuhan China
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- Li, Jinlin (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Department of Cell and Molecular Biology Karolinska Institutet Stockholm Sweden
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- Lundkvist, Åke (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Klinisk mikrobiologi
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- Lindahl, Johanna (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Department of Biosciences International Livestock Research Institute Hanoi Vietnam;Department of Clinical Sciences Swedish University of Agricultural Sciences Uppsala Sweden,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Uppsala University,International Livestock Research Institute (ILRI)
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- Xiong, Yong (author)
- Department of Infectious Diseases Zhongnan Hospital of Wuhan University Wuhan China
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Hu, WJ (author)
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(creator_code:org_t)
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- 2021-06-25
- 2021
- English.
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In: The Journal of Clinical Hypertension. - : John Wiley & Sons. - 1524-6175 .- 1751-7176. ; 23:8, s. 1483-1489
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Abstract
Subject headings
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- Comorbidities are important for the disease outcome of COVID-19, however, which underlying diseases that contribute the most to aggravate the conditions of COVID-19 patients are still unclear. Viral clearance is the most important laboratory test for defining the recovery of COVID-19 infections. To better understand which underlying diseases that are risk factors for delaying the viral clearance, we retrospectively analyzed 161 COVID-19 clinical cases in the Zhongnan Hospital of Wuhan University, Wuhan, China between January 5 and March 13, 2020. The demographic, clinical and laboratory data, as well as patient treatment records were collected. Univariable and multivariable analysis were performed to explore the association between delayed viral clearance and other factors by using logistic regression. Survival analyses by Kaplan-Meier and Cox regression modeling were employed to identify factors negatively influencing the viral clearance negatively. We found that hypertension and intravenous immunoglobulin adversely affected the time of viral RNA shedding. Hypertension was the most important risk factor to delay the SARS-CoV-2 virus clearance, however, the use of Angiotensin-Converting Enzyme Inhibitors(ACEI)/Angiotensin Receptor Blockers(ARB) did not shorten the time for virus clearance in these hypertensive patients’ virus clearance. We conclude that patients having hypertension and intravenous immunoglobulin may delay the viral clearance in COVID-19 patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- COVID-19
- hypertension
- risk factors
- SARS-CoV-2
- viral clearance
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Chen, Xiaoping
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Hu MT, Wenjia
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Yang, Miao
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Ling, Jiaxin
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Zhang, Yongxi
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Deng, Liping
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show more...
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Li, Jinlin
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Lundkvist, Åke
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Lindahl, Johanna
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Xiong, Yong
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Hu, WJ
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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The Journal of C ...
- By the university
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Uppsala University
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Karolinska Institutet
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Swedish University of Agricultural Sciences