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Measurable Residual...
Measurable Residual Disease Monitoring of SPAG6, ST18, PRAME, and XAGE1A Expression in Peripheral Blood May Detect Imminent Relapse in Childhood Acute Myeloid Leukemia
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- Skou, Anne-Sofie (author)
- Aarhus Univ Hosp, Dept Pediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.
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- Juul-Dam, Kristian L. (author)
- Aarhus Univ Hosp, Dept Pediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.
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- Hansen, Maria (author)
- Rigshosp, Dept Clin Genet, Copenhagen, Denmark.
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- Lausen, Birgitte (author)
- Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.
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- Stratmann, Svea, 1989- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi
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- Holmfeldt, Linda (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab
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- Aggerholm, Anni (author)
- Aarhus Univ Hosp, Dept Hematol, Aarhus, Denmark.
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- Nyvold, Charlotte G. (author)
- Univ Southern Denmark, Hematol Pathol Res Lab, Res Unit Hematol, Odense, Denmark.;Univ Southern Denmark, Res Unit Pathol, Odense, Denmark.;Odense Univ Hosp, Odense, Denmark.
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- Ommen, Hans B. (author)
- Aarhus Univ Hosp, Dept Hematol, Aarhus, Denmark.
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- Hasle, Henrik (author)
- Aarhus Univ Hosp, Dept Pediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.
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Aarhus Univ Hosp, Dept Pediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark Rigshosp, Dept Clin Genet, Copenhagen, Denmark. (creator_code:org_t)
- Elsevier, 2021
- 2021
- English.
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In: Journal of Molecular Diagnostics. - : Elsevier. - 1525-1578 .- 1943-7811. ; 23:12, s. 1787-1799
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Overexpressed genes may be useful for monitoring of measurable residual disease (MRD) in patients with childhood acute myeloid leukemia (AML) without a leukemia-specific target. The normal expression of five leukemia-associated genes (SPAG6, ST18, MSLN, PRAME, XAGE1A) was defined in children without hematologic disease (n = 53) and children with suspected infection (n = 90). Gene expression at AML diagnosis (n=50) and during follow-up (n = 21) was compared with child-specific reference values. At diagnosis, 34/50 children (68%) had high expression of at least one of the five genes, and so did 16/31 children (52%) without a leukemia-specific target. Gene expression was quantified in 110 peripheral blood (PB) samples (median, five samples/patient; range, 1 to 10) during follow-up in 21 patients with high expression at diagnosis. All nine patients with PB sampling performed within 100 days of disease recurrence displayed overexpression of SPAG6, ST18, PRAME, or XAGE1A at a median of 2 months (range, 0.6 to 9.6 months) before hematologic relapse, whereas MSLN did not reach expression above normal prior to hematologic relapse. Only 1 of 130 (0.8%) follow-up analyses performed in 10 patients in continuous complete remission had transient expression above normal. SPAG6, ST18, PRAME, and XAGE1A expression in PB may predict relapse in childhood AML patients and facilitate MRD monitoring in most patients without a leukemia-specific target.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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- By the author/editor
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Skou, Anne-Sofie
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Juul-Dam, Kristi ...
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Hansen, Maria
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Lausen, Birgitte
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Stratmann, Svea, ...
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Holmfeldt, Linda
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show more...
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Aggerholm, Anni
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Nyvold, Charlott ...
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Ommen, Hans B.
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Hasle, Henrik
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Journal of Molec ...
- By the university
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Uppsala University