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Environmentally ind...
Environmentally induced DNA methylation is inherited across generations in an aquatic keystone species
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- Feiner, Nathalie (författare)
- Lund University,Lunds universitet,Evolutionär ekologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Evolutionsbiologi,Forskargrupper vid Lunds universitet,Evolutionary ecology,Department of Biology,Faculty of Science,Evolutionary Biology,Lund University Research Groups,Lund Univ, Dept Biol, Lund, Sweden.
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- Radersma, Reinder (författare)
- Lund University,Lunds universitet,Evolutionär ekologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Evolutionary ecology,Department of Biology,Faculty of Science,Centrum Wiskunde & Informatica (CWI),Lund Univ, Dept Biol, Lund, Sweden.;Ctr Wiskunde & Informat, Amsterdam, Netherlands.
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- Vasquez, Louella (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,EPI@LUND,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups,Lund Univ, Dept Lab Med, Sci Life Lab, Natl Bioinformat Infrastructure Sweden, Lund, Sweden.
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- Ringnér, Markus (författare)
- Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science,Lund Univ, Dept Biol, Sci Life Lab, Natl Bioinformat Infrastructure Sweden, Lund, Sweden.
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- Nystedt, Björn, 1978- (författare)
- Uppsala universitet,Uppsala University,Molekylär evolution,Science for Life Laboratory, SciLifeLab
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- Raine, Amanda (författare)
- Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Institutionen för medicinska vetenskaper
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- Tobi, Elmar W. (författare)
- Erasmus University Medical Center,Univ Med Ctr, Div Obstet & Prenatal Med, Dept Obstet & Gynaecol, Periconcept Epidemiol, Rotterdam, Netherlands.;Wageningen Univ & Res, Div Human Nutr & Hlth, Dept Agrotechnol & Food Sci, Wageningen, Netherlands.;Leiden Univ Med Ctr, Dept Biomed Data Sci, Mol Epidemiol, Leiden, Netherlands.
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- Heijmans, Bastiaan T. (författare)
- Leiden University Medical Centre,Leiden Univ Med Ctr, Dept Biomed Data Sci, Mol Epidemiol, Leiden, Netherlands.
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- Uller, Tobias (författare)
- Lund University,Lunds universitet,Evolutionär ekologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Evolutionsbiologi,Forskargrupper vid Lunds universitet,Evolutionary ecology,Department of Biology,Faculty of Science,Evolutionary Biology,Lund University Research Groups,Lund Univ, Dept Biol, Lund, Sweden.
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- Engelska 18 s.
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Ingår i: iScience. - : Elsevier BV. - 2589-0042. ; 25:5
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Transgenerational inheritance of environmentally induced epigenetic marks can have significant impacts on eco-evolutionary dynamics, but the phenomenon remains controversial in ecological model systems. We used whole-genome bisulfite sequencing of individual water fleas (Daphnia magna) to assess whether environmentally induced DNA methylation is transgenerationally inherited. Genetically identical females were exposed to one of three natural stressors, or a de-methylating drug, and their offspring were propagated clonally for four generations under control conditions. We identified between 70 and 225 differentially methylated CpG positions (DMPs) in F1 individuals whose mothers were exposed to a natural stressor. Roughly half of these environmentally induced DMPs persisted until generation F4. In contrast, treatment with the drug demonstrated that pervasive hypomethylation upon exposure is reset almost completely after one generation. These results suggest that environmentally induced DNA methylation is non-random and stably inherited across generations in Daphnia, making epigenetic inheritance a putative factor in the eco-evolutionary dynamics of freshwater communities.
Ämnesord
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
Nyckelord
- Molecular genetics
- DNA methylation
- Epigenetics
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- ref (ämneskategori)
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Feiner, Nathalie
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Radersma, Reinde ...
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Vasquez, Louella
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Ringnér, Markus
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Nystedt, Björn, ...
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Raine, Amanda
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Tobi, Elmar W.
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Heijmans, Bastia ...
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Uller, Tobias
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