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Sökning: WFRF:(Ceelen Wim P.) > The impact of PRODI...

The impact of PRODIGE 7 on the current worldwide practice of CRS-HIPEC for colorectal peritoneal metastases : A web-based survey and 2021 statement by Peritoneal Surface Oncology Group International (PSOGI)

van de Vlasakker, Vincent C. J. (författare)
Catharina Hosp, Dept Surg, Eindhoven, Netherlands.
Lurvink, Robin J. (författare)
Catharina Hosp, Dept Surg, Eindhoven, Netherlands.
Cashin, Peter H., 1984- (författare)
Uppsala universitet,Gastrointestinalkirurgi
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Ceelen, Wim (författare)
Ghent Univ Hosp Belgium, Dept Gastrointestinal Surg, Ghent, Belgium.
Deraco, Marcello (författare)
Fdn IRCCS Inst Nazl Tumori Milano, Dept Surg, Peritoneal Surface Malignancy Unit, Milan, Italy.
Goéré, Diane (författare)
Gustave Roussy, Dept Surg, Villejuif, France.
González-Moreno, Santiago (författare)
MD Anderson Canc Ctr, Dept Surg Oncol, Madrid, Spain.
Lehmann, Kuno (författare)
Univ Hosp Zurich, Dept Visceral & Transplantat Surg, Zurich, Switzerland.
Li, Yan (författare)
Capital Med Univ, Dept Peritoneal Canc Surg, Beijing Shijitan Hosp, Beijing, Peoples R China.
Moran, Brendan (författare)
Hampshire Hosp Fdn Trust, Peritoneal Malignancy Inst Basingstoke, Basingstoke, Hants, England.
Morris, David L. (författare)
St George Hosp, Dept Surg, Sydney, NSW, Australia.
Piso, Pompiliu (författare)
Hosp Barmherzige Bruder, Dept Gen & Visceral Surg, Regensburg, Germany.
Quadros, Claudio A. (författare)
Sao Rafael Hosp, Dept Surg Oncol, Salvador, BA, Brazil.
Rau, Beate (författare)
Charite Univ Med Berlin, Dept Surg, Campus Virchow Klinikum, Berlin, Germany.;Charite Univ Med Berlin, Charite Campus Mitte, Berlin, Germany.
Somashekhar, S. P. (författare)
Manipal Comprehens Canc Ctr, Dept Surg Oncol & Robot Surg, Bengaluru, India.
Sommariva, Antonio (författare)
Veneto Inst Oncol IOV IRCCS Padova, Adv Surg Oncol Unit, Surg Oncol Esophagus & Digest Tract, Padua, Italy.
van der Speeten, Kurt (författare)
Ziekenhuis Oost Limburg, Dept Surg Oncol, Genk, Belgium.
Spiliotis, John (författare)
European Interbalkan Med Ctr, Dept Surg Oncol, Thessaloniki, Greece.
Sugarbaker, Paul H. (författare)
MedStar Washington Hosp Ctr, Ctr Gastrointestinal Malignancies, Washington, DC USA.
Teo, Melissa C. C. (författare)
Natl Canc Ctr, Dept Surg, Singapore, Singapore.
Verwaal, Vic J. (författare)
Hosp South West Jutland, Dept Surg, Esbjerg, Denmark.
Yonemura, Yutaka (författare)
Kishiwada Tokushukai Hosp, Peritoneal Surface Malignancy Ctr, Dept Surg, Kishiwada, Japan.
Glehen, Olivier (författare)
Lyon Sud Hosp, Hosp Civils Lyon, Dept Surg Oncol, Lyon, France.;Lyon Sud Hosp, Lyon Fac Med, Lyon, France.
de Hingh, Ignace H. J. T. (författare)
Catharina Hosp, Dept Surg, Eindhoven, Netherlands.;Maastricht Univ, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands.
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Catharina Hosp, Dept Surg, Eindhoven, Netherlands Gastrointestinalkirurgi (creator_code:org_t)
Elsevier, 2021
2021
Engelska.
Ingår i: European Journal of Surgical Oncology. - : Elsevier. - 0748-7983 .- 1532-2157. ; 47:11, s. 2888-2892
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • IntroductionThe PRODIGE 7-trial investigated the additional value of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) to cytoreductive surgery (CRS) for patients with colorectal peritoneal metastases (CPM). The results of PRODIGE 7 were presented at the 2018 ASCO meeting showing that 30 min oxaliplatin-based HIPEC did not improve overall survival. The current study investigated the impact of PRODIGE 7 on the worldwide practice of CRS and HIPEC.Materials and methodsCRS-HIPEC experts from 19 countries were invited through the Peritoneal Surface Oncology Group International (PSOGI) to complete an online survey concerning the current CRS-HIPEC practice in their hospital and country, and were asked to appraise the effect of PRODIGE 7.ResultsThe survey was completed by 18/19 experts. Although their personal opinions of CRS-HIPEC were barely influenced by PRODIGE 7, they reported a substantial impact on daily practice. This included a switch towards Mitomycin-C based HIPEC-regimens and prolongation of HIPEC perfusion time, a reduction in the number of referrals from non-HIPEC centers, a reduction in national consensus, the removal of HIPEC from national guidelines, and a reduced reimbursement rate.ConclusionThe PRODIGE 7 has had a major impact on the practice of CRS-HIPEC for CPM worldwide. HIPEC remains an attractive option with potential for control and eradication of disease and further studies into the optimal HIPEC-regimen are urgently needed. Meanwhile, given the complexity of the treatment of patients with CPM, and the proven benefits of optimal CRS, referral of patients with potentially resectable CPM to expert centers is recommended whilst the precise role of HIPEC is further evaluated.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

CRS-HIPEC
HIPEC
Colorectal peritoneal metastases
PRODIGE 7

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art (ämneskategori)

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