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  • Sattui, Sebastian E.Hosp Special Surg, Dept Med, Div Rheumatol, 535 E 70th St, New York, NY 10021 USA.;Univ Pittsburgh, Div Rheumatol & Clin Immunol, Pittsburgh, PA 15261 USA. (author)

Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry : a retrospective cohort study

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • Elsevier,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-462479
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-462479URI
  • https://doi.org/10.1016/S2665-9913(21)00316-7DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background Patients with primary systemic vasculitis or polymyalgia rheumatica might be at a high risk for poor COVID-19 outcomes due to the treatments used, the potential organ damage cause by primary systemic vasculitis, and the demographic factors associated with these conditions. We therefore aimed to investigate factors associated with COVID-19 outcomes in patients with primary systemic vasculitis or polymyalgia rheumatica. Methods In this retrospective cohort study, adult patients (aged >= 18 years) diagnosed with COVID-19 between March 12, 2020, and April 12, 2021, who had a history of primary systemic vasculitis (antineutrophil cytoplasmic antibody [ANCA]-associated vasculitis, giant cell arteritis, Behcet's syndrome, or other vasculitis) or polymyalgia rheumatica, and were reported to the COVID-19 Global Rheumatology Alliance registry were included. To assess COVID-19 outcomes in patients, we used an ordinal COVID-19 severity scale, defined as: (1) no hospitalisation; (2) hospitalisation without supplemental oxygen; (3) hospitalisation with any supplemental oxygen or ventilation; or (4) death. Multivariable ordinal logistic regression analyses were used to estimate odds ratios (ORs), adjusting for age, sex, time period, number of comorbidities, smoking status, obesity, glucocorticoid use, disease activity, region, and medication category. Analyses were also stratified by type of rheumatic disease. Findings Of 1202 eligible patients identified in the registry, 733 (61.0%) were women arid 469 (39.0%) were men, and their mean age was 63.8 years (SD 17.1). A total of 374 (31.1%) patients had polymyalgia rheumatica, 353 (29.4%) had ANCA-associated vasculitis, 183 (15.2%) had giant cell arteritis, 112 (9.3%) had Behcet's syndrome, and 180 (15.0%) had other vasculitis. Of 1020 (84. 9%) patients with outcome data, 512 (S0.2%) were not hospitalised, 114 (11.2%) were hospitalised and did not receive supplemental oxygen, 239 (23 - 4%) were hospitalised and received ventilation or supplemental oxygen, and 155 (15.2%) died. A higher odds of poor COVID-19 outcomes were observed in patients who were older (per each additional decade of life OR 1.44 [95% CI 1. 31-1- 571), were male compared with female (1.38 [1.05-1.801), had more comorbidities (per each additional comorbidity 1.39 [1- 23-1- 581), were taking 10 mg/day or more of prednisolone compared with none (2.14 [1.50-3.04J), or had moderate, or high or severe disease activity compared with those who had disease remission or low disease activity (2.12 [1.49-3.021). Risk factors varied among different disease subtypes. Interpretation Among patients with primary systemic vasculitis and polymyalgia rheumatica, severe COVID-19 outcomes were associated with variable and largely unmodifiable risk factors, such as age, sex, and number of comorbidities, as well as treatments, including high-dose glucocorticoids. Our results could be used to info rm mitigation strategies for patients with these diseases. 

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Conway, RichardSt James Hosp, Dept Rheumatol, Dublin D08 NHY1, Ireland. (author)
  • Putman, Michael S.Med Coll Wisconsin, Milwaukee, WI 53226 USA. (author)
  • Seet, Andrea M.Univ Calif San Francisco, Dept Med, Div Rheumatol, San Francisco, CA 94143 USA. (author)
  • Gianfrancesco, Milena A.Univ Calif San Francisco, Dept Med, Div Rheumatol, San Francisco, CA 94143 USA. (author)
  • Beins, KaleyVasculitis Fdn, Kansas City, MO USA. (author)
  • Hill, CatherineQueen Elizabeth Hosp, Rheumatol Unit, Woodville, SA, Australia.;Univ Adelaide, Discipline Med, Adelaide, SA, Australia. (author)
  • Liew, DavidAustin Hlth, Dept Rheumatol, Melbourne, Vic, Australia.;Univ Melbourne, Dept Med, Melbourne, Vic, Australia. (author)
  • Mackie, Sarah L.Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, W Yorkshire, England.;Leeds Teaching Hosp NHS Trust, Leeds Biomed Res Ctr, Leeds, W Yorkshire, England. (author)
  • Mehta, PujaUCL, Ctr Inflammat & Tissue Repair, UCL Resp, London, England.;Univ Coll London Hosp NHS Fdn Trust, Dept Rheumatol, London, England. (author)
  • Neill, LornaPolymyalgia Rheumat & Giant Cell Arteritis Scotla, Perth, Scotland. (author)
  • Gomez, GimenaArgentine Soc Rheumatol, Res Unit, Buenos Aires, DF, Argentina. (author)
  • Salinas, Maria Isabel HayeUniv Nacl la Rioja, Reumatologa CEMMA, La Rioja, Argentina. (author)
  • Maldonado, Federico NicolasSanatorio Guemes Hosp Privado, Buenos Aires, DF, Argentina. (author)
  • Mariz, Henrique AtaideUniv Fed Pernanmbuco, Hosp Clin, Pernanmbuco, Brazil. (author)
  • Studart, Samia Araujo de SousaHosp Geral Fortaleza, Fortaleza, Ceara, Brazil. (author)
  • Araujo, Nafice CostaInst Assistencia Med Servidor Publ Estadual Sao P, Sao Paulo, Brazil. (author)
  • Knight, AnnUppsala universitet,Reumatologi(Swepub:uu)ankni172 (author)
  • Rozza, DavideItalian Soc Rheumatol, Epidemiol Res Unit, Milan, Italy. (author)
  • Quartuccio, LucaUniv Udine, Santa Maria della Misericordia Acad Hosp, Sch Rheumatol, Dept Med,Clin Rheumatol, Udine, Italy. (author)
  • Samson, MaximeDijon Univ Hosp, Dept Internal Med & Clin Immunol, Dijon, France. (author)
  • Bally, StephaneMetropole Savoie Hosp Ctr, Nephrol & Dialysis Serv, Chambery, France. (author)
  • Maria, Alexandre T. J.St Eloi Univ Hosp Montpellier, Dept Internal Med & Multiorgan Dis, Montpellier, France. (author)
  • Chazerain, PascalDiaconesses Croix St Simon Hosp, Dept Rheumatol & Internal Med, Paris, France. (author)
  • Hasseli, RebeccaJustus Liebig Univ Giessen, Dept Rheumatol & Clin Immunol, Campus Kerckhoff, Bad Nauheim, Germany. (author)
  • Muller-Ladner, UlfJustus Liebig Univ Giessen, Dept Rheumatol & Clin Immunol, Campus Kerckhoff, Bad Nauheim, Germany. (author)
  • Hoyer, Bimba F.Univ Hosp Schleswig Holstein, Dept Rheumatol & Clin Immunol, Clin Internal Med 1, Kiel, Germany. (author)
  • Voll, ReinhardAlbert Ludwigs Univ Freiburg, Univ Med Ctr, Fac Med, Dept Rheumatol & Clin Immunol, Freiburg, Germany. (author)
  • Torres, Rita PinheiroNova Med Sch, CEDOC, Lisbon, Portugal.;Egas Moniz Hosp, Lisboa Occidental Hosp Ctr, Rheumatol Serv, Lisbon, Portugal. (author)
  • Luis, MarianaCtr Hosp & Univ Coimbra, Dept Rheumatol, Coimbra, Portugal.;Univ Coimbra, Sch Med, Coimbra, Portugal. (author)
  • Ribeirio, Sandra Lucia EuzebioUniv Fed Amazonas, Manaus, Amazonas, Brazil. (author)
  • Al-Emadi, SamarHamad Med Corp, Doha, Qatar. (author)
  • Sparks, Jeffrey A.Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA. (author)
  • Hsu, Tiffany Y-THarvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA. (author)
  • D'Silva, Kristin M.Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02115 USA. (author)
  • Patel, Naomi J.Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02115 USA. (author)
  • Wise, LeannaLos Angeles Cty Hosp, Los Angeles, CA USA.;Univ South Calif, Med Ctr, Los Angeles, CA 90007 USA. (author)
  • Gilbert, EmilyMayo Clin Hlth Syst, Div Rheumatol, Jacksonville, FL USA. (author)
  • Almada, Maria ValenzuelaMayo Clin Hlth Syst, Div Rheumatol, Rochester, MN USA. (author)
  • Duarte-Garcia, AliMayo Clin Hlth Syst, Div Rheumatol, Rochester, MN USA. (author)
  • Ugarte-Gil, ManuelUniv Cient Sur, Sch Med, Lima, Peru.;EsSalud, Rheumatol Dept, Hosp Guillermo Almenara Irigoyen, Lima, Peru. (author)
  • Jacobsohn, LindsayUniv Calif San Francisco, Dept Med, Div Rheumatol, San Francisco, CA 94143 USA. (author)
  • Izadi, ZaraUniv Calif San Francisco, Dept Med, Div Rheumatol, San Francisco, CA 94143 USA. (author)
  • Strangfeld, AnjaGerman Rheumatism Res Ctr, Epidemiol & Hlth Care Res, Berlin, Germany. (author)
  • Mateus, Elsa F.Portuguese League Rheumat Dis, Lisbon, Portugal. (author)
  • Hyrich, Kimme L.Univ Manchester, Ctr Epidemiol Versus Arthrit, Manchester, Lancs, England.;Univ Manchester, Natl Inst Hlth Res, Manchester Biomed Res Ctr, Manchester, Lancs, England.;Manchester Univ NHS Trust, Natl Inst Hlth Res, Manchester Biomed Res Ctr, Manchester, Lancs, England. (author)
  • Gossec, LaureSorbonne Univ, Inst Pierre Louis Epidemiol & Sante Publ, INSERM, Paris, France.;Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Dept Rheumatol, Paris, France. (author)
  • Carmona, LoretoInst Salud Musculoesquelet, Madrid, Spain. (author)
  • Lawson-Tovey, SaskiaUniv Manchester, Ctr Musculoskeletal Res, Ctr Genet & Gen Versus Arthrit, Manchester, Lancs, England.;Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England. (author)
  • Kearsley-Fleet, LianneUniv Manchester, Ctr Epidemiol Versus Arthrit, Manchester, Lancs, England. (author)
  • Schaefer, MartinGerman Rheumatism Res Ctr, Epidemiol & Hlth Care Res, Berlin, Germany. (author)
  • Sirotich, EmilyMcMaster Univ, Hamilton, ON, Canada.;Canadian Arthrit Patient Alliance, Toronto, ON, Canada. (author)
  • Hausmann, Jonathan S.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA.;Boston Childrens Hosp, Boston, MA USA. (author)
  • Sufka, PaulHealthPartners, St Paul, MN USA. (author)
  • Bhana, SulemanCrystal Run Hlth, Middletown, NY USA. (author)
  • Liew, Jean W.Boston Univ, Sch Med, Boston, MA 02118 USA. (author)
  • Grainger, RebeccaUniv Otago, Wellington, New Zealand. (author)
  • Machado, Pedro M.UCL, Ctr Rheumatol, London, England.;UCL, Dept Neuromuscular Dis, London, England.;Univ Coll London Hosp, Biomed Res Ctr, Natl Inst Hlth Res, London, England.;London North West Univ Healthcare NHS Trust, Northwick Pk Hosp, Dept Rheumatol, London, England. (author)
  • Wallace, Zachary S.Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02115 USA. (author)
  • Yazdany, JinoosUniv Calif San Francisco, Dept Med, Div Rheumatol, San Francisco, CA 94143 USA. (author)
  • Robinson, Philip C.Univ Queensland, Brisbane, Qld, Australia.;Royal Brisbane & Womens Hosp, Metro North Hosp & Hlth Serv, Herston, Qld, Australia. (author)
  • Hosp Special Surg, Dept Med, Div Rheumatol, 535 E 70th St, New York, NY 10021 USA.;Univ Pittsburgh, Div Rheumatol & Clin Immunol, Pittsburgh, PA 15261 USA.St James Hosp, Dept Rheumatol, Dublin D08 NHY1, Ireland. (creator_code:org_t)

Related titles

  • In:The Lancet Rheumatology: Elsevier3:12, s. E855-E8642665-9913

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