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Functional improvem...
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Skoglund, ElisabethUppsala universitet,Klinisk nutrition och metabolism,Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Alfred Nobles Allé 8B, 141 52 Huddinge, Sweden & Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
(author)
Functional improvements to 6 months of physical activity are not related to changes in size or density of multiple lower-extremity muscles in mobility-limited older individuals
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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Elsevier BV,2022
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LIBRIS-ID:oai:DiVA.org:uu-462872
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-462872URI
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https://doi.org/10.1016/j.exger.2021.111631DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:148434009URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Older adults are encouraged to engage in multicomponent physical activity, which includes aerobic and muscle-strengthening activities. The current work is an extension of the Vitality, Independence, and Vigor in the Elderly 2 (VIVE2) study - a 6-month multicenter, randomized, placebo-controlled trial of physical activity and nutritional supplementation in community dwelling 70-year-old seniors. Here, we examined whether the magnitude of changes in muscle size and quality differed between major lower-extremity muscle groups and related these changes to functional outcomes. We also examined whether daily vitamin-D-enriched protein supplementation could augment the response to structured physical activity. Forty-nine men and women (77 ± 5 yrs) performed brisk walking, muscle-strengthening exercises for the lower limbs, and balance training 3 times weekly for 6 months. Participants were randomized to daily intake of a nutritional supplement (20 g whey protein + 800 IU vitamin D), or a placebo. Muscle cross-sectional area (CSA) and radiological attenuation (RA) were assessed in 8 different muscle groups using single-slice CT scans of the hip, thigh, and calf at baseline and after the intervention. Walking speed and performance in the Short Physical Performance Battery (SPPB) were also measured. For both CSA and RA, there were muscle group × time interactions (P < 0.01). Significant increases in CSA were observed in 2 of the 8 muscles studied, namely the knee extensors (1.9%) and the hip adductors (2.8%). For RA, increases were observed in 4 of 8 muscle groups, namely the hip flexors (1.1 HU), hip adductors (0.9 HU), knee extensors (1.2 HU), and ankle dorsiflexors (0.8 HU). No additive effect of nutritional supplementation was observed. While walking speed (13%) and SPPB performance (38%) improved markedly, multivariate analysis showed that these changes were not associated with the changes in muscle CSA and RA after the intervention. We conclude that this type of multicomponent physical activity program results in significant improvements in physical function despite relatively small changes in muscle size and quality of some, but not all, of the measured lower extremity muscles involved in locomotion.
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Lundberg, Tommy RKarolinska Institutet
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Rullman, EricKarolinska Institutet
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Fielding, Roger ANutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
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Kirn, Dylan RNutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
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Englund, Davis ANutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
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von Berens, AsaUppsala universitet,Klinisk nutrition och metabolism,Stockholm Gerontology Research Center, Sveavägen 155, 113 46 Stockholm, Sweden(Swepub:uu)asavo144
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Koochek, AfsanehUppsala universitet,Institutionen för kostvetenskap(Swepub:uu)afsko376
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Cederholm, TommyUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)tomce419
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Berg, Hans EKarolinska Institutet
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Gustafsson, ThomasKarolinska Institutet
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Uppsala universitetKlinisk nutrition och metabolism
(creator_code:org_t)
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In:Experimental Gerontology: Elsevier BV1570531-55651873-6815
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von Berens, Asa
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