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  • Cheng, Guang‐ShingClinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington (författare)

Multicenter evaluation of parametric response mapping as an indicator of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • Wiley,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-463320
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-463320URI
  • https://doi.org/10.1111/ajt.15814DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:144302384URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Parametric response mapping (PRM) is a novel computed tomography (CT) technology that has shown potential for assessment of bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HCT). The primary aim of this study was to evaluate whether variations in image acquisition under real-world conditions affect the PRM measurements of clinically diagnosed BOS. CT scans were obtained retrospectively from 72 HCT recipients with BOS and graft-versus-host disease from Fred Hutchinson Cancer Research Center, Karolinska Institute, and the University of Michigan. Whole lung volumetric scans were performed at inspiration and expiration using site-specific acquisition and reconstruction protocols. PRM and pulmonary function measurements were assessed. Patients with moderately severe BOS at diagnosis (median forced expiratory volume at 1 second [FEV1] 53.5% predicted) had similar characteristics between sites. Variations in site-specific CT acquisition protocols had a negligible effect on the PRM-derived small airways disease (SAD), that is, BOS measurements. PRM-derived SAD was found to correlate with FEV1% predicted and FEV1/ forced vital capacity (R = −0.236, P = .046; and R = −0.689, P < .0001, respectively), which suggests that elevated levels in the PRM measurements are primarily affected by BOS airflow obstruction and not CT scan acquisition parameters. Based on these results, PRM may be applied broadly for post-HCT diagnosis and monitoring of BOS.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Selwa, Katherine E.University of Michigan Medical School Ann Arbor Michigan (författare)
  • Hatt, CharlesImbio, LLC Minneapolis Minneapolis Minnesota (författare)
  • Ram, SundareshDepartment of Radiology Michigan Medicine Ann Arbor Michigan (författare)
  • Fortuna, Aleksa B.Department of Radiology Michigan Medicine Ann Arbor Michigan (författare)
  • Guerriero, MargaretSeattle Cancer Care Alliance Seattle Washington (författare)
  • Himelhoch, BenMichigan State University College of Human Medicine Lansing Michigan (författare)
  • McAree, DanielPediatrics University of Michigan Ann Arbor Michigan (författare)
  • Hoffman, Timothy C.University of Michigan Medical School Ann Arbor Michigan (författare)
  • Brisson, JosephBlood and Marrow Transplant Program Michigan Medicine Ann Arbor Michigan (författare)
  • Nazareno, RyanBlood and Marrow Transplant Program Michigan Medicine Ann Arbor Michigan (författare)
  • Bloye, KiernanBlood and Marrow Transplant Program Michigan Medicine Ann Arbor Michigan (författare)
  • Johnson, Timothy D.Department of Biostatistics University of Michigan School of Public Health Ann Arbor Michigan (författare)
  • Remberger, Mats,Professor,1955-Uppsala universitet,Hematologi,Department of Oncology‐Pathology Karolinska University Hospital Stockholm Sweden(Swepub:uu)matre804 (författare)
  • Mattsson, JonasKarolinska Institutet (författare)
  • Vummidi, DharshanDepartment of Radiology Michigan Medicine Ann Arbor Michigan (författare)
  • Kazerooni, Ella E.Department of Radiology Michigan Medicine Ann Arbor Michigan (författare)
  • Lama, Vibha N.Division of Pulmonary and Critical Care Medicine Michigan Medicine Ann Arbor Michigan (författare)
  • Galban, StefanieDepartment of Radiology Michigan Medicine Ann Arbor Michigan (författare)
  • Boeckh, MichaelClinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington (författare)
  • Yanik, Gregory A.Blood and Marrow Transplant Program Michigan Medicine Ann Arbor Michigan (författare)
  • Galban, Craig J.Department of Radiology Michigan Medicine Ann Arbor Michigan (författare)
  • Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WashingtonUniversity of Michigan Medical School Ann Arbor Michigan (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:American Journal of Transplantation: Wiley20:8, s. 2198-22051600-61351600-6143

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