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Intracranial and su...
Intracranial and subcortical volumes in adolescents with early‐onset psychosis : A multisite mega‐analysis from the ENIGMA consortium
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- Gurholt, Tiril P. (författare)
- Norwegian Center for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction Oslo University Hospital Oslo Norway;Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine University of Oslo Oslo Norway;Department of Psychiatric Research Diakonhjemmet Hospital Oslo Norway
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- Lonning, Vera (författare)
- Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine University of Oslo Oslo Norway;Department of Psychiatric Research Diakonhjemmet Hospital Oslo Norway
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- Nerland, Stener (författare)
- Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine University of Oslo Oslo Norway;Department of Psychiatric Research Diakonhjemmet Hospital Oslo Norway
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- Jørgensen, Kjetil N. (författare)
- Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine University of Oslo Oslo Norway;Department of Psychiatric Research Diakonhjemmet Hospital Oslo Norway
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- Haukvik, Unn K. (författare)
- Norwegian Center for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction Oslo University Hospital Oslo Norway;Department of Adult Mental Health, Institute of Clinical Medicine University of Oslo Oslo Norway
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- Alloza, Clara (författare)
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM Madrid Spain
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- Arango, Celso (författare)
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM Madrid Spain;School of Medicine Universidad Complutense Madrid Spain
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- Barth, Claudia (författare)
- Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine University of Oslo Oslo Norway
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- Bearden, Carrie E. (författare)
- Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior UCLA Los Angeles California USA;Department of Psychology UCLA Los Angeles California USA
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- Berk, Michael (författare)
- IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University Geelong Victoria Australia;Orygen Youth Health Research Center The Florey Institute for Neuroscience and Department of Psychiatry Parkville Victoria Australia
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- Bohman, Hannes, 1965- (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för kvinnors och barns hälsa,Ramklint: Barn- och ungdomspsykiatri,Center for Psychiatry Research, Department of Clinical Neuroscience Karolinska Institutet and Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden Stockholm Sweden;Department of Clinical Science and Education Södersjukhuset Karolinska Institutet Stockholm Sweden,Ulf Jonsson
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- Dandash, Orwa (författare)
- IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University Geelong Victoria Australia
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- Díaz‐Caneja, Covadonga M. (författare)
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM Madrid Spain;School of Medicine Universidad Complutense Madrid Spain
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- Edbom, Carl T. (författare)
- Center for Psychiatry Research, Department of Clinical Neuroscience Karolinska Institutet and Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden Stockholm Sweden
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- Erp, Theo G. M. (författare)
- Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior University of California Irvine Irvine California USA;Center for the Neurobiology of Learning University of California Irvine and Memory Irvine California USA
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- Fett, Anne‐Kathrin J. (författare)
- Department of Psychology City, University of London London UK;Department of Psychosis Studies IoPPN London UK;Department of Clinical, Neuro and Developmental Psychology VU Amsterdam Amsterdam Netherlands
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- Frangou, Sophia (författare)
- Department of Psychiatry Icahn School of Medicine at Mount Sinai New York New York USA
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- Goldstein, Benjamin I. (författare)
- Center for Youth Bipolar Disorder, Sunnybrook Health Science Center Toronto Ontario Canada;Department of Psychiatry and Pharmacology University of Toronto Canada
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- Grigorian, Anahit (författare)
- Center for Youth Bipolar Disorder, Sunnybrook Health Science Center Toronto Ontario Canada
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- Jahanshad, Neda (författare)
- Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine University of Southern California Marina del Rey California USA
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- James, Anthony C. (författare)
- Department of Psychiatry University of Oxford Oxford UK;Oxford Health Foundation NHS Trust Oxford UK
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- Janssen, Joost (författare)
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM Madrid Spain;School of Medicine Universidad Complutense Madrid Spain
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- Johannessen, Cecilie (författare)
- Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine University of Oslo Oslo Norway
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- Karlsgodt, Katherine H. (författare)
- Department of Psychology UCLA Los Angeles California USA;Department Psychiatry and Biobehavioral Sciences UCLA Los Angeles California USA
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- Kempton, Matthew J. (författare)
- Department of Psychosis Studies King's College London London UK
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- Kochunov, Peter (författare)
- Maryland Psychiatric Research Center, Department of Psychiatry University of Maryland School of Medicine Baltimore Maryland USA
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- Krabbendam, Lydia (författare)
- Department of Clinical, Neuro and Developmental Psychology VU Amsterdam Amsterdam Netherlands
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- Kyriakopoulos, Marinos (författare)
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience King's College London London UK;National and Specialist Children's Inpatient Unit (Acorn Lodge), South London and Maudsley NHS Foundation Trust Beckenham UK
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- Lundberg, Mathias (författare)
- Karolinska Institutet,Uppsala universitet,Ramklint: Barn- och ungdomspsykiatri,Center for Psychiatry Research, Department of Clinical Neuroscience Karolinska Institutet and Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden;Department of Neuroscience, Department of Clinical Science and Education Södersjukhuset Karolinska Institutet Stockholm Sweden;The Department of Clinical Science and Education KI SÖS Stockholm Sweden
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- MacIntosh, Bradley J. (författare)
- Hurvitz Brain Sciences, Sunnybrook Research Institute Toronto Ontario Canada;Department of Medical Biophysics University of Toronto Ontario Canada
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- Rund, Bjørn Rishovd (författare)
- Department of Psychology University of Oslo Oslo Norway;Department of Research Vestre Viken Hospital Trust Drammen Norway
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- Smelror, Runar E. (författare)
- Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine University of Oslo Oslo Norway;Department of Psychiatric Research Diakonhjemmet Hospital Oslo Norway
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- Sultan, Alysha (författare)
- Department of Psychiatry Icahn School of Medicine at Mount Sinai New York New York USA;Department of Pharmacology University of Toronto Toronto Ontario Canada
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- Tamnes, Christian K. (författare)
- Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine University of Oslo Oslo Norway;Department of Psychiatric Research Diakonhjemmet Hospital Oslo Norway;PROMENTA Research Center, Department of Psychology University of Oslo Oslo Norway
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- Thomopoulos, Sophia I. (författare)
- Department of Psychiatry and Pharmacology University of Toronto Canada
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- Vajdi, Ariana (författare)
- Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior UCLA Los Angeles California USA
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- Wedervang‐Resell, Kirsten (författare)
- Norwegian Center for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction Oslo University Hospital Oslo Norway
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- Myhre, Anne M. (författare)
- Child and Adolescent Psychiatry Unit, Division of Mental Health and Addiction, Institute of Clinical Medicine University of Oslo Oslo Norway;Department of Psychiatric Research and Development, Division of Mental Health and Addiction Oslo University Hospital Oslo Norway
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- Andreassen, Ole A. (författare)
- Norwegian Center for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction Oslo University Hospital Oslo Norway;Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine University of Oslo Oslo Norway
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- Thompson, Paul M. (författare)
- Department of Psychiatry and Pharmacology University of Toronto Canada
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- Agartz, Ingrid (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-10-05
- 2020
- Engelska.
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Ingår i: Human Brain Mapping. - Stockholm : Wiley. - 1065-9471 .- 1097-0193. ; 43:1, s. 373-384
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Abstract
Ämnesord
Stäng
- Early-onset psychosis disorders are serious mental disorders arising before the age of 18 years. Here, we investigate the largest neuroimaging dataset, to date, of patients with early-onset psychosis and healthy controls for differences in intracranial and subcortical brain volumes. The sample included 263 patients with early-onset psychosis (mean age: 16.4 ± 1.4 years, mean illness duration: 1.5 ± 1.4 years, 39.2% female) and 359 healthy controls (mean age: 15.9 ± 1.7 years, 45.4% female) with magnetic resonance imaging data, pooled from 11 clinical cohorts. Patients were diagnosed with early-onset schizophrenia (n = 183), affective psychosis (n = 39), or other psychotic disorders (n = 41). We used linear mixed-effects models to investigate differences in intracranial and subcortical volumes across the patient sample, diagnostic subgroup and antipsychotic medication, relative to controls. We observed significantly lower intracranial (Cohen's d = −0.39) and hippocampal (d = −0.25) volumes, and higher caudate (d = 0.25) and pallidum (d = 0.24) volumes in patients relative to controls. Intracranial volume was lower in both early-onset schizophrenia (d = −0.34) and affective psychosis (d = −0.42), and early-onset schizophrenia showed lower hippocampal (d = −0.24) and higher pallidum (d = 0.29) volumes. Patients who were currently treated with antipsychotic medication (n = 193) had significantly lower intracranial volume (d = −0.42). The findings demonstrate a similar pattern of brain alterations in early-onset psychosis as previously reported in adult psychosis, but with notably low intracranial volume. The low intracranial volume suggests disrupted neurodevelopment in adolescent early-onset psychosis.
Nyckelord
- adolescence
- antipsychotics
- brain structure
- early-onset
- intracranial volume
- psychosis spectrum
- Child and Youth Psychiatry
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- art (ämneskategori)
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- Av författaren/redakt...
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Gurholt, Tiril P ...
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Lonning, Vera
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Nerland, Stener
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Jørgensen, Kjeti ...
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Haukvik, Unn K.
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Alloza, Clara
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visa fler...
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Arango, Celso
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Barth, Claudia
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Bearden, Carrie ...
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Berk, Michael
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Bohman, Hannes, ...
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Dandash, Orwa
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Díaz‐Caneja, Cov ...
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Edbom, Carl T.
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Erp, Theo G. M.
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Fett, Anne‐Kathr ...
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Frangou, Sophia
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Goldstein, Benja ...
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Grigorian, Anahi ...
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Jahanshad, Neda
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James, Anthony C ...
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Janssen, Joost
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Johannessen, Cec ...
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Karlsgodt, Kathe ...
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Kempton, Matthew ...
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Kochunov, Peter
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Krabbendam, Lydi ...
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Kyriakopoulos, M ...
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Lundberg, Mathia ...
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MacIntosh, Bradl ...
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Rund, Bjørn Rish ...
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Smelror, Runar E ...
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Sultan, Alysha
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Tamnes, Christia ...
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Thomopoulos, Sop ...
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Vajdi, Ariana
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Wedervang‐Resell ...
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Myhre, Anne M.
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Andreassen, Ole ...
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Thompson, Paul M ...
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Agartz, Ingrid
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Uppsala universitet
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