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Salicylic Acid and ...
Salicylic Acid and Risk of Colorectal Cancer : A Two-Sample Mendelian Randomization Study
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- Nounu, Aayah (författare)
- Univ Bristol, Integrat Canc Epidemiol Programme ICEP, Bristol Med Sch, Med Res Council MRC,Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England.;Univ Bristol, Sch Cellular & Mol Med, Bristol BS8 1TD, Avon, England.,Integrative Cancer Epidemiology Programme (ICEP), Medical Research Council (MRC) Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom; School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
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- Richmond, Rebecca C. (författare)
- Univ Bristol, Integrat Canc Epidemiol Programme ICEP, Bristol Med Sch, Med Res Council MRC,Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England.,Integrative Cancer Epidemiology Programme (ICEP), Medical Research Council (MRC) Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom
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- Stewart, Isobel D. (författare)
- Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge CB2 0SL, England.,MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
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visa fler...
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- Surendran, Praveen (författare)
- Univ Cambridge, Dept Publ Hlth & Primary Care, British Heart Fdn, Cardiovasc Epidemiol Unit, Cambridge CB1 8RN, England.;Univ Cambridge, Div Cardiovasc Med, British Heart Fdn, Ctr Res Excellence, Cambridge CB2 0QQ, England.;Wellcome Genome Campus, Hlth Data Res UK Cambridge, Cambridge CB10 1SA, England.;Univ Cambridge, Cambridge CB10 1SA, England.;Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England.,British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom; Rutherford Fund Fellow, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
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- Wareham, Nicholas J. (författare)
- Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge CB2 0SL, England.,MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
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- Butterworth, Adam (författare)
- Univ Cambridge, Dept Publ Hlth & Primary Care, British Heart Fdn, Cardiovasc Epidemiol Unit, Cambridge CB1 8RN, England.;Univ Cambridge, Div Cardiovasc Med, British Heart Fdn, Ctr Res Excellence, Cambridge CB2 0QQ, England.;Wellcome Genome Campus, Hlth Data Res UK Cambridge, Cambridge CB10 1SA, England.;Univ Cambridge, Cambridge CB10 1SA, England.;Univ Cambridge, Natl Inst Hlth Res, Blood & Transplant Res Unit Donor Hlth & Genom, Cambridge CB2 1TN, England.;Univ Cambridge, Cambridge Univ Hosp, Natl Inst Hlth Res, Cambridge Biomed Res Ctr, Cambridge Biomed Campus, Cambridge CB2 0QQ, England.,British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom; National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge University Hospitals, Cambridge, United Kingdom
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- Weinstein, Stephanie J. (författare)
- NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20814 USA.,Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Albanes, Demetrius (författare)
- NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20814 USA.,Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Baron, John A. (författare)
- Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27516 USA.,Department of Medicine, School of Medicine, University of North Carolina, NC, Chapel Hill, United States
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- Hopper, John L. (författare)
- Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic 3053, Australia.;Seoul Natl Univ, Inst Hlth & Environm, Sch Publ Hlth, Dept Epidemiol, Seoul 08826, South Korea.,Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea,Department of Family Medicine, University of Virginia, VA, Charlottesville, United States
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- Figueiredo, Jane C. (författare)
- Cedars Sinai Med Ctr, Dept Med, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA.;Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90007 USA.,Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Newcomb, Polly A. (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.;Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA.,Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; School of Public Health, University of Washington, WA, Seattle, United States
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- Lindor, Noralane M. (författare)
- Mayo Clin, Dept Hlth Sci Res, Scottsdale, AZ 85259 USA.,Department of Health Science Research, Mayo Clinic, AZ, Scottsdale, United States
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- Casey, Graham (författare)
- Univ Virginia, Dept Publ Hlth Sci, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA.,Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States
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- Platz, Elizabeth A. (författare)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.,Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States,Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Marchand, Loic Le (författare)
- Univ Hawaii, Ctr Canc, Canc Epidemiol Program, Honolulu, HI 96813 USA.,Cancer Epidemiology Program, University of Hawaii Cancer Center, Office of Public Health Studies, HI, Honolulu, United States
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- Ulrich, Cornelia M. (författare)
- Univ Utah, Huntsman Canc Inst, Dept Populat Hlth Sci, Salt Lake City, UT 84112 USA.,Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
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- Li, Christopher I. (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.,Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- van Dujinhoven, Fraenzel J. B. (författare)
- Wageningen Univ & Res, Div Human Nutr & Hlth, Dept Agrotechnol & Food Sci, NL-6700 HB Wageningen, Netherlands.,Division of Human Nutrition and Health, Department of Agrotechnology and Food Sciences, Wageningen University & Research, Wageningen, Netherlands
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- Gsur, Andrea (författare)
- Med Univ Vienna, Inst Canc Res, Dept Med 1, A-1090 Vienna, Austria.,Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria
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- Campbell, Peter T. (författare)
- Amer Canc Soc, Dept Populat Sci, Atlanta, GA 30303 USA.,Department of Population Science, American Cancer Society, GA, Atlanta, United States
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- Moreno, Victor (författare)
- Catalan Inst Oncol IDIBELL, Oncol Data Analyt Program, Barcelona 08908, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain.;Univ Barcelona, Dept Clin Sci, Fac Med, Barcelona 08007, Spain.;Bellvitge Biomed Res Inst IDIBELL, ONCOBEL Program, Barcelona 08908, Spain.,Oncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain; ONCOBEL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain
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- Vodicka, Pavel (författare)
- Czech Acad Sci, Inst Expt Med, Dept Mol Biol Canc, Prague 14220, Czech Republic.;Charles Univ Prague, Inst Biol & Med Genet, Fac Med 1, Prague 12108, Czech Republic.;Charles Univ Prague, Fac Med, Plzen 32300, Czech Republic.;Charles Univ Prague, Biomed Ctr Pilsen, Plzen 32300, Czech Republic.,Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Nové Město, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
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- Vodickova, Ludmila (författare)
- Czech Acad Sci, Inst Expt Med, Dept Mol Biol Canc, Prague 14220, Czech Republic.;Charles Univ Prague, Inst Biol & Med Genet, Fac Med 1, Prague 12108, Czech Republic.;Charles Univ Prague, Fac Med, Plzen 32300, Czech Republic.;Charles Univ Prague, Biomed Ctr Pilsen, Plzen 32300, Czech Republic.,Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Nové Město, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
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- Amitay, Efrat (författare)
- German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany.,Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Alwers, Elizabeth (författare)
- German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany.
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- Chang-Claude, Jenny (författare)
- German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany.;Univ Med Ctr Hamburg Eppendorf, Univ Canc Ctr Hamburg UCCH, Dept Oncol Haematol & BMT, D-20251 Hamburg, Germany.,Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Oncology, Haematology and BMT, University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany
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- Sakoda, Lori C. (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.;Kaiser Permanente Northern Calif, Div Res, Oakland, CA 94612 USA.,Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
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- Slattery, Martha L. (författare)
- Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA.,Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States
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- Schoen, Robert E. (författare)
- Univ Pittsburgh, Med Ctr, Dept Med & Epidemiol, Pittsburgh, PA 15261 USA.,Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States
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- Gunter, Marc J. (författare)
- WHO, Nutr & Metab Sect, Int Agcy Res Canc, F-69372 Lyon, France.,Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Castellvi-Bel, Sergi (författare)
- Univ Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Gastroenterol Dept,Hosp Clin, Barcelona 08036, Spain.,Gastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain
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- Kim, Hyeong-Rok (författare)
- Chonnam Natl Univ, Dept Surg, Hwasun Hosp, Hwasun 58128, South Korea.;Med Sch, Hwasun 58128, South Korea.,Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Hwasun, South Korea
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- Kweon, Sun-Seog (författare)
- Chonnam Natl Univ, Dept Prevent Med, Med Sch, Gwangju 61186, South Korea.;Chonnam Natl Univ, Jeonnam Reg Canc Ctr, Hwasun Hosp, Hwasun 58128, South Korea.,Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea; Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, South Korea
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- Chan, Andrew T. (författare)
- Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA 02114 USA.;Brigham & Womens Hosp, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.;Broad Inst Harvard & MIT, Cambridge, MA 02142 USA.;Harvard Univ, Dept Epidemiol, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA.;Harvard Univ, Dept Immunol & Infect Dis, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA.,Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
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- Li, Li (författare)
- Univ Virginia, Dept Family Med, Charlottesville, VA 22903 USA.,Integrative Cancer Epidemiology Programme (ICEP), Medical Research Council (MRC) Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom
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- Zheng, Wei (författare)
- Vanderbilt Univ, Sch Med, Vanderbilt Epidemiol Ctr, Vanderbilt Ingram Canc Ctr,Div Epidemiol,Dept Med, Nashville, TN 37232 USA.,Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, TN, Nashville, United States
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- Bishop, D. Timothy (författare)
- Univ Leeds, Leeds Inst Canc & Pathol, Sch Med, Leeds LS2 9JT, W Yorkshire, England.,Leeds Institute of Cancer and Pathology, School of Medicine, University of Leeds, Leeds, United Kingdom
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- Buchanan, Daniel D. (författare)
- Univ Melbourne, Dept Clin Pathol, Colorectal Oncogen Grp, Parkville, Vic 3010, Australia.;Univ Melbourne, Melbourne Med Sch, Victorian Comprehens Canc Ctr, Ctr Canc Res, Parkville, Vic 3010, Australia.;Royal Melbourne Hosp, Genet Med & Family Canc Clin, Parkville, Vic 3000, Australia.,Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, VIC, Parkville, Australia; Melbourne Medical School, University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Genetic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, VIC, Parkville, Australia
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- Giles, Graham G. (författare)
- Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic 3053, Australia.;Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic 3004, Australia.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic 3168, Australia.,Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
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- Gruber, Stephen B. (författare)
- Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.;Univ Southern Calif, Keck Sch Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA.,Department of Preventive Medicine & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Rennert, Gad (författare)
- Lady Davis Carmel Med Ctr, Dept Community Med & Epidemiol, IL-3448516 Haifa, Israel.;Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, IL-3200003 Haifa, Israel.;Clalit Natl Canc Control Ctr, IL-3436212 Haifa, Israel.,Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel
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- Stadler, Zsofia K. (författare)
- Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA.,Memorial Sloan Kettering Cancer Center, Department of Medicine, NY, New York, United States
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- Harrison, Tabitha A. (författare)
- Wageningen Univ & Res, Div Human Nutr & Hlth, Dept Agrotechnol & Food Sci, NL-6700 HB Wageningen, Netherlands.,Division of Human Nutrition and Health, Department of Agrotechnology and Food Sciences, Wageningen University & Research, Wageningen, Netherlands
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- Lin, Yi (författare)
- Wageningen Univ & Res, Div Human Nutr & Hlth, Dept Agrotechnol & Food Sci, NL-6700 HB Wageningen, Netherlands.,Division of Human Nutrition and Health, Department of Agrotechnology and Food Sciences, Wageningen University & Research, Wageningen, Netherlands
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- Keku, Temitope O. (författare)
- Univ N Carolina, Sch Med, Ctr Gastrointestinal Biol & Dis, Chapel Hill, NC 27599 USA.,Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, NC, Chapel Hill, United States
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- Woods, Michael O. (författare)
- Mem Univ Newfoundland, Discipline Genet, Fac Med, St John, NF A1B 3V6, Canada.,Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, NL, St. John’s, Canada
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- Schafmayer, Clemens (författare)
- Univ Hosp Rostock, Dept Gen Surg, D-18057 Rostock, Germany.,Department of General Surgery, University Hospital Rostock, Rostock, Germany
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- van Guelpen, Bethany (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi,Patologi
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- Gallinger, Steven (författare)
- Univ Toronto, Lunenfeld Tanenbaum Res Inst, Mt Sinai Hosp, Fac Med, Toronto, ON M5G 1X5, Canada.,Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Faculty of Medicine, University of Toronto, ON, Toronto, Canada
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- Hampel, Heather (författare)
- Ohio State Univ, Ctr Comprehens Canc, Dept Internal Med, Div Human Genet, Columbus, OH 43210 USA.,Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, OH, Columbus, United States,Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Berndt, Sonja I. (författare)
- NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20814 USA.,Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Pharoah, Paul D. P. (författare)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England.,Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
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- Lindblom, Annika (författare)
- Karolinska Institutet,Department of Clinical Genetics, Karolinska University Hospital, Solna, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden
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- Wolk, Alicja (författare)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, S-17164 Solna, Sweden.,Institute of Environmental Medicine, Karolinska Institutet, Solna, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Wu, Anna H. (författare)
- Univ Southern Calif, Keck Sch Med, Dept Populat & Publ Hlth Sci, Los Angeles, CA 90032 USA.
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- White, Emily (författare)
- Wageningen Univ & Res, Div Human Nutr & Hlth, Dept Agrotechnol & Food Sci, NL-6700 HB Wageningen, Netherlands.;Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.,Division of Human Nutrition and Health, Department of Agrotechnology and Food Sciences, Wageningen University & Research, Wageningen, Netherlands; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
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- Peters, Ulrike (författare)
- Wageningen Univ & Res, Div Human Nutr & Hlth, Dept Agrotechnol & Food Sci, NL-6700 HB Wageningen, Netherlands.;Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.,Division of Human Nutrition and Health, Department of Agrotechnology and Food Sciences, Wageningen University & Research, Wageningen, Netherlands; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
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- Drew, David A. (författare)
- Brigham & Womens Hosp, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.;Broad Inst Harvard & MIT, Cambridge, MA 02142 USA.,Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States
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- Scherer, Dominique (författare)
- Heidelberg Univ, Inst Med Biometry & Informat, Med Fac, Neuenheimer Feld 130-3, D-69120 Heidelberg, Germany.,Institute of Medical Biometry and Informatics, Medical Faculty, University of Heidelberg, Im Neuenheimer Feld 130.3, Heidelberg, Germany
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- Bermejo, Justo Lorenzo (författare)
- Heidelberg Univ, Inst Med Biometry & Informat, Med Fac, Neuenheimer Feld 130-3, D-69120 Heidelberg, Germany.,Institute of Medical Biometry and Informatics, Medical Faculty, University of Heidelberg, Im Neuenheimer Feld 130.3, Heidelberg, Germany
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- Brenner, Hermann (författare)
- German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany.;German Canc Res Ctr, Div Prevent Oncol, Natl Ctr Tumor Dis NCT, D-69120 Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, D-69120 Heidelberg, Germany.,Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Hoffmeister, Michael (författare)
- German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany.,Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Williams, Ann C. (författare)
- Univ Bristol, Sch Cellular & Mol Med, Bristol BS8 1TD, Avon, England.,School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
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- Relton, Caroline L. (författare)
- Univ Bristol, Integrat Canc Epidemiol Programme ICEP, Bristol Med Sch, Med Res Council MRC,Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England.
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Univ Bristol, Integrat Canc Epidemiol Programme ICEP, Bristol Med Sch, Med Res Council MRC,Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England;Univ Bristol, Sch Cellular & Mol Med, Bristol BS8 1TD, Avon, England. Integrative Cancer Epidemiology Programme (ICEP), Medical Research Council (MRC) Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom; School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom (creator_code:org_t)
- 2021-11-21
- 2021
- Engelska.
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Ingår i: Nutrients. - : MDPI. - 2072-6643. ; 13:11
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Salicylic acid (SA) has observationally been shown to decrease colorectal cancer (CRC) risk. Aspirin (acetylsalicylic acid, that rapidly deacetylates to SA) is an effective primary and secondary chemopreventive agent. Through a Mendelian randomization (MR) approach, we aimed to address whether levels of SA affected CRC risk, stratifying by aspirin use. A two-sample MR analysis was performed using GWAS summary statistics of SA (INTERVAL and EPIC-Norfolk, N = 14,149) and CRC (CCFR, CORECT, GECCO and UK Biobank, 55,168 cases and 65,160 controls). The DACHS study (4410 cases and 3441 controls) was used for replication and stratification of aspirin-use. SNPs proxying SA were selected via three methods: (1) functional SNPs that influence the activity of aspirin-metabolising enzymes; (2) pathway SNPs present in enzymes' coding regions; and (3) genome-wide significant SNPs. We found no association between functional SNPs and SA levels. The pathway and genome-wide SNPs showed no association between SA and CRC risk (OR: 1.03, 95% CI: 0.84-1.27 and OR: 1.08, 95% CI: 0.86-1.34, respectively). Results remained unchanged upon aspirin use stratification. We found little evidence to suggest that an SD increase in genetically predicted SA protects against CRC risk in the general population and upon stratification by aspirin use.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- salicylic acid
- aspirin
- colorectal cancer
- Mendelian randomization
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- ref (ämneskategori)
- art (ämneskategori)
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Nounu, Aayah
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Richmond, Rebecc ...
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Stewart, Isobel ...
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Surendran, Prave ...
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Wareham, Nichola ...
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Butterworth, Ada ...
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visa fler...
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Weinstein, Steph ...
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Albanes, Demetri ...
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Baron, John A.
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Hopper, John L.
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Figueiredo, Jane ...
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Newcomb, Polly A ...
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Lindor, Noralane ...
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Casey, Graham
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Platz, Elizabeth ...
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Marchand, Loic L ...
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Ulrich, Cornelia ...
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Li, Christopher ...
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van Dujinhoven, ...
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Gsur, Andrea
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Campbell, Peter ...
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Moreno, Victor
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Vodicka, Pavel
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Vodickova, Ludmi ...
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Amitay, Efrat
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Alwers, Elizabet ...
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Chang-Claude, Je ...
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Sakoda, Lori C.
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Slattery, Martha ...
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Schoen, Robert E ...
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Gunter, Marc J.
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Castellvi-Bel, S ...
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Kim, Hyeong-Rok
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Kweon, Sun-Seog
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Chan, Andrew T.
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Li, Li
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Zheng, Wei
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Bishop, D. Timot ...
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Buchanan, Daniel ...
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Giles, Graham G.
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Gruber, Stephen ...
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Rennert, Gad
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Stadler, Zsofia ...
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Harrison, Tabith ...
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Lin, Yi
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Keku, Temitope O ...
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Woods, Michael O ...
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Schafmayer, Clem ...
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van Guelpen, Bet ...
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Gallinger, Steve ...
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Hampel, Heather
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Berndt, Sonja I.
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Pharoah, Paul D. ...
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Lindblom, Annika
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Wolk, Alicja
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Wu, Anna H.
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White, Emily
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Peters, Ulrike
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Drew, David A.
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Scherer, Dominiq ...
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Bermejo, Justo L ...
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Brenner, Hermann
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