Aberrant default mode connectivity in adolescents with early-onset psychosis: A resting state fMRI study

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Aberrant default mode connectivity in adolescents with early-onset psychosis : A resting state fMRI study

Hilland, Eva (författare): Univ Oslo, Norwegian Ctr Mental Disorders Res NORMENT, Inst Clin Med, Oslo, Norway.;Oslo Metropolitan Univ, Fac Hlth Sci, Oslo, Norway

Johannessen, Cecilie (författare): Univ Oslo, Norwegian Ctr Mental Disorders Res NORMENT, Inst Clin Med, Oslo, Norway

Jonassen, Rune (författare): Oslo Metropolitan Univ, Fac Hlth Sci, Oslo, Norway

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Alnaes, Dag (författare): Bjorknes Coll, Oslo, Norway.;Oslo Univ Hosp, Norwegian Ctr Mental Disorders Res NORMENT, Div Mental Hlth & Addict, Oslo, Norway

Jorgensen, Kjetil N. (författare): Univ Oslo, Norwegian Ctr Mental Disorders Res NORMENT, Inst Clin Med, Oslo, Norway.;Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway

Barth, Claudia (författare): Univ Oslo, Norwegian Ctr Mental Disorders Res NORMENT, Inst Clin Med, Oslo, Norway.;Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway

Andreou, Dimitrios (författare): Karolinska Institutet

Nerland, Stener (författare): Univ Oslo, Norwegian Ctr Mental Disorders Res NORMENT, Inst Clin Med, Oslo, Norway.;Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway

Wortinger, Laura A. (författare): Univ Oslo, Norwegian Ctr Mental Disorders Res NORMENT, Inst Clin Med, Oslo, Norway.;Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway

Smelror, Runar E. (författare): Univ Oslo, Norwegian Ctr Mental Disorders Res NORMENT, Inst Clin Med, Oslo, Norway.;Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway

Wedervang-Resell, Kirsten (författare): Oslo Univ Hosp, Norwegian Ctr Mental Disorders Res NORMENT, Div Mental Hlth & Addict, Oslo, Norway

Bohman, Hannes, 1965- (författare): Karolinska Institutet,Uppsala universitet,Ramklint: Barn- och ungdomspsykiatri,Institutionen för medicinska vetenskaper,Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Stockholm Regio, Sweden.;Stockholm Hlth Care Serv, Stockholm, Stockholm Regio, Sweden.;Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Stockholm, Sweden

Lundberg, Mathias (författare): Uppsala universitet,Ramklint: Barn- och ungdomspsykiatri,Institutionen för medicinska vetenskaper,Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Stockholm Regio, Sweden.;Stockholm Hlth Care Serv, Stockholm, Stockholm Regio, Sweden;Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Stockholm, Sweden

Westlye, Lars T. (författare): Oslo Univ Hosp, Norwegian Ctr Mental Disorders Res NORMENT, Div Mental Hlth & Addict, Oslo, Norway.;Univ Oslo, Dept Psychol, Oslo, Norway

Andreassen, Ole A. (författare): Univ Oslo, Norwegian Ctr Mental Disorders Res NORMENT, Inst Clin Med, Oslo, Norway.;Oslo Univ Hosp, Norwegian Ctr Mental Disorders Res NORMENT, Div Mental Hlth & Addict, Oslo, Norway

Jonsson, Erik G. (författare): Karolinska Institutet

Agartz, Ingrid (författare): Karolinska Institutet

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Univ Oslo, Norwegian Ctr Mental Disorders Res NORMENT, Inst Clin Med, Oslo, Norway;Oslo Metropolitan Univ, Fac Hlth Sci, Oslo, Norway Univ Oslo, Norwegian Ctr Mental Disorders Res NORMENT, Inst Clin Med, Oslo, Norway (creator_code:org_t)

Elsevier, 2022
2022
Engelska.
Ingår i: NeuroImage. - : Elsevier. - 2213-1582. ; 33

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://doi.org/10.1...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

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Abnormal default mode network (DMN) connectivity has been found in schizophrenia and other psychotic disorders. However, there are limited studies on early onset psychosis (EOP), and their results show lack of agreement. Here, we investigated within-network DMN connectivity in EOP compared to healthy controls (HC), and its relationship to clinical characteristics. A sample of 68 adolescent patients with EOP (mean age 16.53 +/- 1.12 [SD] years, females 66%) and 95 HC (mean age 16.24 +/- 1.50 [SD], females 60%) from two Scandinavian cohorts underwent resting state functional magnetic resonance imaging (rsfMRI). A group independent component analysis (ICA) was performed to identify the DMN across all participants. Dual regression was used to estimate spatial maps reflecting each participant's DMN network, which were compared between EOP and HC using voxel-wise general linear models and permutation-based analyses. Subgroup analyses were performed within the patient group, to explore associations between diagnostic subcategories and current use of psychotropic medication in relation to connectivity strength. The analysis revealed significantly reduced DMN connectivity in EOP compared to HC in the posterior cingulate cortex, precuneus, fusiform cortex, putamen, pallidum, amygdala, and insula. The subgroup analysis in the EOP group showed strongest deviations for affective psychosis, followed by other psychotic disorders and schizophrenia. There was no association between DMN connectivity strength and the current use of psychotropic medication. In conclusion, the findings demonstrate weaker DMN connectivity in adolescent patients with EOP compared to healthy peers, and differential effects across diagnostic subcategories, which may inform our understanding of underlying disease mechanisms in EOP.

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Av författaren/redakt...: Hilland, Eva; Johannessen, Cec ...; Jonassen, Rune; Alnaes, Dag; Jorgensen, Kjeti ...; Barth, Claudia; visa fler...; Andreou, Dimitri ...; Nerland, Stener; Wortinger, Laura ...; Smelror, Runar E ...; Wedervang-Resell ...; Bohman, Hannes, ...; Lundberg, Mathia ...; Westlye, Lars T.; Andreassen, Ole ...; Jonsson, Erik G.; Agartz, Ingrid; visa färre...

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Av lärosätet: Uppsala universitet; Karolinska Institutet

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Aberrant default mode connectivity in adolescents with early-onset psychosis : A resting state fMRI study

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