Sökning: WFRF:(Nyström Petra Witt) >
Treatment plan comp...
Treatment plan comparison of proton vs photon radiotherapy for lower-grade gliomas
-
- Byskov, Camilla S. (författare)
- Aarhus Univ Hosp, Dept Oncol, Aarhus, Denmark.;Aarhus Univ Hosp, Danish Ctr Particle Therapy, Blvd 99, DK-8200 Aarhus N, Denmark.
-
- Hansen, Christian R. (författare)
- Aarhus Univ Hosp, Danish Ctr Particle Therapy, Blvd 99, DK-8200 Aarhus N, Denmark.;Odense Univ Hosp, Dept Oncol, Odense, Denmark.;Odense Univ Hosp, Lab Radiat Phys, Odense, Denmark.
-
- Dahlrot, Rikke H. (författare)
- Aarhus Univ Hosp, Danish Ctr Particle Therapy, Blvd 99, DK-8200 Aarhus N, Denmark.;Odense Univ Hosp, Dept Oncol, Odense, Denmark.;Univ Southern Denmark, Inst Clin Res, Odense, Denmark.
-
visa fler...
-
- Haldbo-Classen, Lene (författare)
- Aarhus Univ Hosp, Dept Oncol, Aarhus, Denmark.
-
- Haslund, Charlotte A. (författare)
- Aalborg Univ Hosp, Dept Oncol, Aalborg, Denmark.
-
- Kjaer-Kristoffersen, Flemming (författare)
- Rigshosp, Dept Oncol, Copenhagen, Denmark.
-
- Kristensen, Thomas O. (författare)
- Aalborg Univ Hosp, Dept Oncol, Aalborg, Denmark.
-
- Lassen-Ramshad, Yasmin (författare)
- Aarhus Univ Hosp, Danish Ctr Particle Therapy, Blvd 99, DK-8200 Aarhus N, Denmark.
-
- Lukacova, Slavka (författare)
- Aarhus Univ Hosp, Dept Oncol, Aarhus, Denmark.
-
- Muhic, Aida (författare)
- Rigshosp, Dept Oncol, Copenhagen, Denmark.
-
- Witt Nyström, Petra (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Aarhus Univ Hosp, Danish Ctr Particle Therapy, Blvd 99, DK-8200 Aarhus N, Denmark.;Uppsala Univ Hosp, Dept Oncol, Uppsala, Sweden.
-
- Weber, Britta (författare)
- Aarhus Univ Hosp, Danish Ctr Particle Therapy, Blvd 99, DK-8200 Aarhus N, Denmark.
-
- Kallehauge, Jesper F. (författare)
- Aarhus Univ Hosp, Danish Ctr Particle Therapy, Blvd 99, DK-8200 Aarhus N, Denmark.;Aarhus Univ, Dept Clin Med, Aarhus, Denmark.
-
visa färre...
-
Aarhus Univ Hosp, Dept Oncol, Aarhus, Denmark;Aarhus Univ Hosp, Danish Ctr Particle Therapy, Blvd 99, DK-8200 Aarhus N, Denmark. Aarhus Univ Hosp, Danish Ctr Particle Therapy, Blvd 99, DK-8200 Aarhus N, Denmark.;Odense Univ Hosp, Dept Oncol, Odense, Denmark.;Odense Univ Hosp, Lab Radiat Phys, Odense, Denmark. (creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
-
Ingår i: Physics and Imaging in Radiation Oncology. - : Elsevier. - 2405-6316. ; 20, s. 98-104
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
http://phiro.science...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background and purpose: Patients with lower-grade gliomas are long-term survivors after radiotherapy and may benefit from the reduced dose to normal tissue achievable with proton therapy. Here, we aimed to quantify differences in dose to the uninvolved brain and contralateral hippocampus and compare the risk of radiation-induced secondary cancer for photon and proton plans for lower-grade glioma patients. Materials and methods: Twenty-three patients were included in this in-silico planning comparative study and had photon and proton plans calculated (50.4 Gy(RBE = 1.1), 28 Fx) applying similar dose constraints to the target and organs at risk. Automatically calculated photon plans were generated with a 3 mm margin from clinical target volume (CTV) to planning target volume. Manual proton plans were generated using robust optimisation on the CTV. Dose metrics of organs at risk were compared using population mean dose-volume histograms and Wilcoxon signed-rank test. Secondary cancer risk per 10,000 persons per year (PPY) was estimated using dose-volume data and a risk model for secondary cancer induction. Results: CTV coverage (V95%>98%) was similar for the two treatment modalities. Mean dose (D-mean) to the uninvolved brain was significantly reduced from 21.5 Gy (median, IQR 17.1-24.4 Gy) with photons compared to 10.3 Gy(RBE) (8.1-13.9 Gy(RBE)) with protons. D-mean to the contralateral hippocampus was significantly reduced from 6.5 Gy (5.4-11.7 Gy) with photons to 1.5 Gy(RBE) (0.4-6.8 Gy(RBE)) with protons. The estimated secondary cancer risk was reduced from 6.7 PPY (median, range 3.3-10.4 PPY) with photons to 3.0 PPY (1.3-7.5 PPY) with protons. Conclusion: A significant reduction in mean dose to uninvolved brain and contralateral hippocampus was found with proton planning. The estimated secondary cancer risk was reduced with proton therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Brain cancer
- Radiotherapy
- proton therapy
- Treatment Planning
- secondary cancer risk
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Byskov, Camilla ...
-
Hansen, Christia ...
-
Dahlrot, Rikke H ...
-
Haldbo-Classen, ...
-
Haslund, Charlot ...
-
Kjaer-Kristoffer ...
-
visa fler...
-
Kristensen, Thom ...
-
Lassen-Ramshad, ...
-
Lukacova, Slavka
-
Muhic, Aida
-
Witt Nyström, Pe ...
-
Weber, Britta
-
Kallehauge, Jesp ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Physics and Imag ...
- Av lärosätet
-
Uppsala universitet