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In vivo fitness of ...
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Nutman, AmirTel Aviv Sourasky Med Ctr, Div Epidemiol & Prevent Med, Tel Aviv, Israel.;Israel Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel.;Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
(författare)
In vivo fitness of carbapenem-resistant Acinetobacter baumannii strains in murine infection is associated with treatment failure in human infections
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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Elsevier,2022
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-463645
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-463645URI
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https://doi.org/10.1016/j.cmi.2021.05.005DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Objectives: Mortality among patients with carbapenem-resistant Acinetobacter baumannii (CRAB) infections varies between studies. We examined whether in vivo fitness of CRAB strains is associated with clinical outcomes in patients with CRAB infections.Methods: Isolates were collected from patients enrolled in the AIDA trial with hospital-acquired pneumonia, bloodstream infections and/or urinary tract infections caused by CRAB. The primary outcome was 14-day clinical failure, defined as failure to meet all criteria: alive; haemodynamically stable; improved or stable Sequential Organ Failure Assessment (SOFA) score; improved or stable oxygenation; and microbiological cure of bacteraemia. The secondary outcome was 14-day mortality. We tested in vivo growth using a neutropenic murine thigh infection model. Fitness was defined based on the CFU count 24 hours after injection of an inoculum of 105 CFU. We used mixed-effects logistic regression to test the association between fitness and the two outcomes.Results: The sample included 266 patients; 215 (80.8%) experienced clinical failure. CRAB fitness ranged from 5.23 to 10.08 log CFU/g. The odds of clinical failure increased by 62% for every 1-log CFU/g increase in fitness (OR 1.62, 95% CI 1.04-2.52). After adjusting for age, Charlson score, SOFA score and acquisition in the intensive care unit, fitness remained significant (adjusted OR 1.63, 95% CI 1.03-2.59). CRAB fitness had a similar effect on 14-day mortailty, although the association was not statistically significant (OR 1.56, 95% CI 0.95-2.57). It became significant after adjusting for age, Charlson score, SOFA score and recent surgery (adjusted OR 1.88, 95% CI 1.09-3.25).Conclusions: In vivo CRAB fitness was associated with clinical failure in patients with CRAB infection.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Temkin, ElizabethTel Aviv Sourasky Med Ctr, Div Epidemiol & Prevent Med, Tel Aviv, Israel.;Israel Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel.;Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
(författare)
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Lellouche, JonathanIsrael Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel.
(författare)
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Rakovitsky, NadyaIsrael Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel.
(författare)
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Hameir, AmichayIsrael Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel.
(författare)
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Daikos, GeorgeNatl & Kapodistrian Univ Athens, Laikon Gen Hosp, Dept Med 1, Athens, Greece.
(författare)
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Durante-Mangoni, EmanueleUniv Campania Luigi Vanvitelli, AORN Colli Monaldi Hosp, Dept Precis Med, Naples, Italy.
(författare)
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Pavleas, IoannisLaikon Gen Hosp, Intens Care Unit, Athens, Greece.
(författare)
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Dishon, YaelRambam Hlth Care Campus, Inst Infect Dis, Haifa, Israel.;Univ Haifa, Cheryl Spencer Inst Nursing Res, Haifa, Israel.
(författare)
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Petersiel, NetaRambam Hlth Care Campus, Inst Infect Dis, Haifa, Israel.
(författare)
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Yahav, DafnaTel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.;Beilinson Med Ctr, Rabin Med Ctr, Infect Dis Unit, Petah Tiqwa, Israel.
(författare)
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Eliakim, NoaTel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.;Beilinson Med Ctr, Rabin Med Ctr, Dept Med E, Petah Tiqwa, Israel.
(författare)
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Bernardo, MarianoUniv Campania Luigi Vanvitelli, AORN Colli Monaldi Hosp, Dept Precis Med, Naples, Italy.
(författare)
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Iossa, DomenicoUniv Campania Luigi Vanvitelli, AORN Colli Monaldi Hosp, Dept Precis Med, Naples, Italy.
(författare)
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Friberg, LenaUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)lenasimo
(författare)
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Theuretzbacher, UrsulaCtr Antiinfect Agents, Vienna, Austria.
(författare)
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Leibovici, LeonardTel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.;Beilinson Med Ctr, Rabin Med Ctr, Dept Med E, Petah Tiqwa, Israel.
(författare)
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Paul, MicalRambam Hlth Care Campus, Inst Infect Dis, Haifa, Israel.;Tech Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Haifa, Israel.
(författare)
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Carmeli, YehudaTel Aviv Sourasky Med Ctr, Div Epidemiol & Prevent Med, Tel Aviv, Israel.;Israel Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel.;Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
(författare)
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Tel Aviv Sourasky Med Ctr, Div Epidemiol & Prevent Med, Tel Aviv, Israel.;Israel Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel.;Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.Israel Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinical Microbiology and Infection: Elsevier28:1, s. 73-781198-743X1469-0691
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Nutman, Amir
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Temkin, Elizabet ...
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Lellouche, Jonat ...
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Rakovitsky, Nady ...
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Hameir, Amichay
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Daikos, George
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visa fler...
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Durante-Mangoni, ...
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Pavleas, Ioannis
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Dishon, Yael
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Petersiel, Neta
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Yahav, Dafna
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Eliakim, Noa
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Bernardo, Marian ...
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Iossa, Domenico
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Friberg, Lena
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Theuretzbacher, ...
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Leibovici, Leona ...
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Paul, Mical
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Carmeli, Yehuda
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