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  • Nutman, AmirTel Aviv Sourasky Med Ctr, Div Epidemiol & Prevent Med, Tel Aviv, Israel.;Israel Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel.;Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel. (författare)

In vivo fitness of carbapenem-resistant Acinetobacter baumannii strains in murine infection is associated with treatment failure in human infections

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Elsevier,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-463645
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-463645URI
  • https://doi.org/10.1016/j.cmi.2021.05.005DOI

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  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objectives: Mortality among patients with carbapenem-resistant Acinetobacter baumannii (CRAB) infections varies between studies. We examined whether in vivo fitness of CRAB strains is associated with clinical outcomes in patients with CRAB infections.Methods: Isolates were collected from patients enrolled in the AIDA trial with hospital-acquired pneumonia, bloodstream infections and/or urinary tract infections caused by CRAB. The primary outcome was 14-day clinical failure, defined as failure to meet all criteria: alive; haemodynamically stable; improved or stable Sequential Organ Failure Assessment (SOFA) score; improved or stable oxygenation; and microbiological cure of bacteraemia. The secondary outcome was 14-day mortality. We tested in vivo growth using a neutropenic murine thigh infection model. Fitness was defined based on the CFU count 24 hours after injection of an inoculum of 105 CFU. We used mixed-effects logistic regression to test the association between fitness and the two outcomes.Results: The sample included 266 patients; 215 (80.8%) experienced clinical failure. CRAB fitness ranged from 5.23 to 10.08 log CFU/g. The odds of clinical failure increased by 62% for every 1-log CFU/g increase in fitness (OR 1.62, 95% CI 1.04-2.52). After adjusting for age, Charlson score, SOFA score and acquisition in the intensive care unit, fitness remained significant (adjusted OR 1.63, 95% CI 1.03-2.59). CRAB fitness had a similar effect on 14-day mortailty, although the association was not statistically significant (OR 1.56, 95% CI 0.95-2.57). It became significant after adjusting for age, Charlson score, SOFA score and recent surgery (adjusted OR 1.88, 95% CI 1.09-3.25).Conclusions: In vivo CRAB fitness was associated with clinical failure in patients with CRAB infection. 

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Temkin, ElizabethTel Aviv Sourasky Med Ctr, Div Epidemiol & Prevent Med, Tel Aviv, Israel.;Israel Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel.;Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel. (författare)
  • Lellouche, JonathanIsrael Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel. (författare)
  • Rakovitsky, NadyaIsrael Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel. (författare)
  • Hameir, AmichayIsrael Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel. (författare)
  • Daikos, GeorgeNatl & Kapodistrian Univ Athens, Laikon Gen Hosp, Dept Med 1, Athens, Greece. (författare)
  • Durante-Mangoni, EmanueleUniv Campania Luigi Vanvitelli, AORN Colli Monaldi Hosp, Dept Precis Med, Naples, Italy. (författare)
  • Pavleas, IoannisLaikon Gen Hosp, Intens Care Unit, Athens, Greece. (författare)
  • Dishon, YaelRambam Hlth Care Campus, Inst Infect Dis, Haifa, Israel.;Univ Haifa, Cheryl Spencer Inst Nursing Res, Haifa, Israel. (författare)
  • Petersiel, NetaRambam Hlth Care Campus, Inst Infect Dis, Haifa, Israel. (författare)
  • Yahav, DafnaTel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.;Beilinson Med Ctr, Rabin Med Ctr, Infect Dis Unit, Petah Tiqwa, Israel. (författare)
  • Eliakim, NoaTel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.;Beilinson Med Ctr, Rabin Med Ctr, Dept Med E, Petah Tiqwa, Israel. (författare)
  • Bernardo, MarianoUniv Campania Luigi Vanvitelli, AORN Colli Monaldi Hosp, Dept Precis Med, Naples, Italy. (författare)
  • Iossa, DomenicoUniv Campania Luigi Vanvitelli, AORN Colli Monaldi Hosp, Dept Precis Med, Naples, Italy. (författare)
  • Friberg, LenaUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)lenasimo (författare)
  • Theuretzbacher, UrsulaCtr Antiinfect Agents, Vienna, Austria. (författare)
  • Leibovici, LeonardTel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.;Beilinson Med Ctr, Rabin Med Ctr, Dept Med E, Petah Tiqwa, Israel. (författare)
  • Paul, MicalRambam Hlth Care Campus, Inst Infect Dis, Haifa, Israel.;Tech Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Haifa, Israel. (författare)
  • Carmeli, YehudaTel Aviv Sourasky Med Ctr, Div Epidemiol & Prevent Med, Tel Aviv, Israel.;Israel Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel.;Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel. (författare)
  • Tel Aviv Sourasky Med Ctr, Div Epidemiol & Prevent Med, Tel Aviv, Israel.;Israel Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel.;Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.Israel Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Clinical Microbiology and Infection: Elsevier28:1, s. 73-781198-743X1469-0691

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