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Influence of the ag...
Influence of the age at diagnosis in the disease expression of primary Sjogren's syndrome : Analysis of 12,753 patients from the Sjogren Big Data Consortium
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- Retamozo, S. (author)
- Inst Univ Ciencias Biomed Cordoba IUCBC, Inst Modelo Cardiol Privado SRL, Cordoba, Argentina.;Hosp Univ Parc Tauli, Rheumatol Dept, Barcelona, Spain.
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- Acar-Denizli, N. (author)
- Univ Politecn Cataluna, Dept Stat & Operat Res, Barcelona, Spain.
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- Horvath, I. F. (author)
- Univ Debrecen, Fac Med, Div Clin Immunol, Debrecen, Hungary.
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show more...
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- Ng, W-F (author)
- Newcastle Univ, NIHR Biomed Res Ctr, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England.
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- Rasmussen, A. (author)
- Oklahoma Med Res Fdn, Genes & Human Dis Res Program, 825 NE 13th St, Oklahoma City, OK 73104 USA.
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- Dong, X. (author)
- Peking Union Med Coll Hosp, Dept Rheumatol, Beijing, Peoples R China.
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- Li, X. (author)
- Anhui Prov Hosp, Dept Rheumatol & Immunol, Hefei, Peoples R China.
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- Baldini, C. (author)
- Univ Pisa, Rheumatol Unit, Pisa, Italy.
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- Olsson, P. (author)
- Lund Univ, Skane Univ Hosp Malmö, Dept Rheumatol, Lund, Sweden.
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- Priori, R. (author)
- Sapienza Univ Rome, Dept Internal Med & Med Specialties, Rheumatol Clin, Rome, Italy.;UniCamillus, St Camillus Int Univ Hlth Sci, Rome, Italy.
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- Seror, R. (author)
- Hop Univ Paris Sud, AP HP, Ctr Immunol Viral Infect & Autoimmune Dis, Le Kremlin Bicetre, France.;Univ Paris Sud, INSERM, Paris, France.
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- Gottenberg, J-E (author)
- Univ Strasbourg, Strasbourg Univ Hosp, Dept Rheumatol, CNRS, Strasbourg, France.
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- Kruize, A. A. (author)
- Univ Med Ctr Utrecht, Dept Rheumatol & Clin Immunol, Utrecht, Netherlands.
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- Hernandez-Molina, G. (author)
- Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Immunol & Rheumatol Dept, Mexico City, DF, Mexico.
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- Vissink, A. (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Oral & Maxillofacial Surg, Groningen, Netherlands.
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- Sandhya, P. (author)
- Christian Med Coll & Hosp, Dept Clin Immunol & Rheumatol, Vellore, Tamil Nadu, India.
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- Armagan, B. (author)
- Hacettepe Univ, Fac Med, Dept Internal Med, Ankara, Turkey.
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- Quartuccio, L. (author)
- Univ Hosp Santa Maria della Misericordia, Dept Med & Biol Sci, Clin Rheumatol, Udine, Italy.
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- Sebastian, A. (author)
- Wroclaw Med Hosp, Dept Rheumatol & Internal Med, Wroclaw, Poland.
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- Praprotnik, S. (author)
- Univ Med Ctr, Dept Rheumatol, Ljubljana, Slovenia.
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- Bartoloni, E. (author)
- Univ Perugia, Dept Med, Rheumatol Unit, Perugia, Italy.
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- Kwok, S-K (author)
- Catholic Univ Korea, Coll Med, Dept Internal Med, Div Rheumatol,Seoul St Marys Hosp, Seoul, South Korea.
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- Kvarnstrom, M. (author)
- Karolinska Institutet
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- Rischmueller, M. (author)
- Univ Adelaide, Queen Elizabeth Hosp, Dept Rheumatol, Discipline Med, Adelaide, SA, Australia.
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- Solans-Laque, R. (author)
- Hosp Valle De Hebron, Dept Internal Med, Barcelona, Spain.
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- Sene, D. (author)
- Univ Paris VII, Serv Med Interne 2, Hop Lariboisiere, Paris, France.
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- Pasoto, S. G. (author)
- Univ Sao Paulo, Hosp Clin HCFMUSP, Rheumatol Div, Fac Med, Sao Paulo, Brazil.
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- Suzuki, Y. (author)
- Kanazawa Univ Hosp, Div Rheumatol, Kanazawa, Ishikawa, Japan.
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- Isenberg, D. A. (author)
- UCL, Ctr Rheumatol, Div Med, London, England.
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- Valim, V. (author)
- Univ Fed Espirito Santo, Dept Med, Vitoria, ES, Brazil.
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- Nordmark, Gunnel (author)
- Uppsala universitet,Reumatologi
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- Nakamura, H. (author)
- Nagasaki Univ, Dept Immunol & Rheumatol, Div Adv Prevent Med Sci, Grad Sch Biomed Sci, Nagasaki, Japan.
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- Fernandes Moca Trevisani, V (author)
- Univ Fed Sao Paulo, Div Hlth Based Evidence, Sao Paulo, Brazil.
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- Hofauer, B. (author)
- Tech Univ Munich, Otorhinolaryngol Head & Neck Surg, Munich, Germany.
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- Siso-Almirall, A. (author)
- Consorci Atencio Primaria Salut Barcelona Esquerr, Primary Care Ctr Corts, Barcelona, Spain.
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- Giacomelli, R. (author)
- Univ Aquila, Sch Med, Clin Unit Rheumatol, Laquila, Italy.
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- Devauchelle-Pensec, V (author)
- Brest Univ Hosp, Rheumatol Dept, Brest, France.
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- Bombardieri, M. (author)
- Queen Mary Univ London, Ctr Expt Med & Rheumatol, London, England.
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- Atzeni, F. (author)
- Univ Messina, IRCCS Galeazzi Orthopaed Inst, Milan & Rheumatol Unit, Messina, Italy.
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- Hammenfors, D. (author)
- Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haenglandeland Univ Hosp, Dept Rheumatol, Bergen, Norway.
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- Maure, B. (author)
- Complexo Hosp Univ Vigo, Dept Internal Med, Vigo, Spain.
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- Carsons, S. E. (author)
- NYU, Div Rheumatol Allergy & Immunol, Winthrop Hosp, New York, NY USA.;NYU Langone Hlth, New York, NY USA.
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- Gheita, T. (author)
- Cairo Univ, Kasr Al Ainy Sch Med, Rheumatol Dept, Giza, Egypt.
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- Sanchez-Berna, I (author)
- Hosp Rey Juan Carlos Mostoles, Dept Internal Med, Madrid, Spain.
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- Lopez-Dupla, M. (author)
- Hosp Joan 23, Dept Internal Med, Tarragona, Spain.
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- Morel, J. (author)
- Teaching Hosp, Dept Rheumatol, Montpellier, France.;Univ Montpellier, Montpellier, France.
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- Inanc, N. (author)
- Marmara Univ, Sch Med, Istanbul, Turkey.
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- Fonseca-Aizpuru, E. (author)
- Hosp Cabuenes, Dept Internal Med, Gijon, Spain.
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- Morcillo, C. (author)
- Hosp CIMA Sanitas, Dept Med, Autoimmune Dis Unit, Barcelona, Spain.
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- Vollenweider, C. (author)
- German Hosp, Buenos Aires, DF, Argentina.
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- Melchor, S. (author)
- Hosp 12 Octubre, Dept Rheumatol, Madrid, Spain.
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- Vazquez, M. (author)
- Hosp Clin, Dept Rheumatol, San Lorenzo, Paraguay.
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- Diaz-Cuiza, E. (author)
- Seguro Social Univ & Consultorio Privado Reumatol, Dept Reumatol, Sucre, Bolivia.
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- Consani-Fernandez, S. (author)
- Hosp Maciel, Internal Med, Montevideo, Uruguay.;Univ Republ UdelaR, Montevideo, Uruguay.
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- de-Miguel-Campo, B. (author)
- Hosp 12 Octubre, Dept Internal Med, Madrid, Spain.
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- Szanto, A. (author)
- Univ Debrecen, Fac Med, Div Clin Immunol, Debrecen, Hungary.
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- Bombardieri, S. (author)
- Univ Pisa, Rheumatol Unit, Pisa, Italy.
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- Gattamelata, A. (author)
- Sapienza Univ Rome, Dept Internal Med & Med Specialties, Rheumatol Clin, Rome, Italy.
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- Hinrichs, A. (author)
- Univ Med Ctr Utrecht, Dept Rheumatol & Clin Immunol, Utrecht, Netherlands.
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- Sanchez-Guerrero, J. (author)
- Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Immunol & Rheumatol Dept, Mexico City, DF, Mexico.
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- Danda, D. (author)
- Christian Med Coll & Hosp, Dept Clin Immunol & Rheumatol, Vellore, Tamil Nadu, India.
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- Kilic, L. (author)
- Hacettepe Univ, Fac Med, Dept Internal Med, Ankara, Turkey.
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- de Vita, S. (author)
- Univ Hosp Santa Maria della Misericordia, Dept Med & Biol Sci, Clin Rheumatol, Udine, Italy.
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- Wiland, P. (author)
- Wroclaw Med Hosp, Dept Rheumatol & Internal Med, Wroclaw, Poland.
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- Gerli, R. (author)
- Univ Perugia, Dept Med, Rheumatol Unit, Perugia, Italy.
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- Park, S-H (author)
- Catholic Univ Korea, Coll Med, Dept Internal Med, Div Rheumatol,Seoul St Marys Hosp, Seoul, South Korea.
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- Wahren-Herlenius, M. (author)
- Karolinska Institutet
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- Bootsma, H. (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Rheumatol & Clin Immunol, Groningen, Netherlands.
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- Mariette, X. (author)
- Hop Univ Paris Sud, AP HP, Ctr Immunol Viral Infect & Autoimmune Dis, Le Kremlin Bicetre, France.;Univ Paris Sud, INSERM, Paris, France.
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- Ramos-Casals, M. (author)
- Univ Barcelona, Hosp Clin, Dept Autoimmune Dis, ICMiD, Barcelona, Spain.
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- Brito-Zeron, P. (author)
- Hosp CIMA Sanitas, Dept Med, Autoimmune Dis Unit, Barcelona, Spain.
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Inst Univ Ciencias Biomed Cordoba IUCBC, Inst Modelo Cardiol Privado SRL, Cordoba, Argentina;Hosp Univ Parc Tauli, Rheumatol Dept, Barcelona, Spain. Univ Politecn Cataluna, Dept Stat & Operat Res, Barcelona, Spain. (creator_code:org_t)
- CLINICAL & EXPER RHEUMATOLOGY, 2021
- 2021
- English.
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In: Clinical and Experimental Rheumatology. - : CLINICAL & EXPER RHEUMATOLOGY. - 0392-856X .- 1593-098X. ; 39:6, s. S166-S174
- Related links:
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https://www.clinexpr...
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https://urn.kb.se/re...
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http://kipublication...
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https://doi.org/10.5...
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Abstract
Subject headings
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- Objective. To analyse how the main components of the disease phenotype (sicca symptoms, diagnostic tests, immunological markers and systemic disease) can be driven by the age at diagnosis of primary Sjogren's syndrome (pSS).Methods. By January 2021, the participant centres had included 12,753 patients from 25 countries that fulfilled the 2002/2016 classification criteria for pSS. The age at diagnosis was defined as the time when the attending physician confirmed fulfilment of the criteria. Patients were clustered according to age at diagnosis. 50 clusters with more than 100 observations (from 27 to 76 years) were used to study the influence of the age at diagnosis in the disease expression.Results. There was a consistent increase in the frequency of oral dryness according to the age at diagnosis, with a frequency of <90% in patients diagnosed at the youngest ages and >95% in those diagnosed at the oldest ages. The smooth curves that best fitted a linear model were the frequency of dry mouth (adjusted R-2 0.87) and the frequency of abnormal oral tests (adjusted R-2 0.72). Therefore, for each 1-year increase in the age at diagnosis, the frequency of dry mouth increased by 0.13%, and the frequency of abnormal oral diagnostic tests by 0.11%. There was a consistent year-by-year decrease in the frequency of all autoantibodies and immunological markers except for cryoglobulins. According to the linear models, for each 1-year increase in the age at diagnosis, the frequency of a positive result decreased by 0.57% (for anti-Ro antibodies), 0.47% (for RF) and 0.42% (for anti-La antibodies). The ESSDAI domains which showed a more consistent decrease were glandular and lymph node involvement (for each 1-year increase in the age at diagnosis, the frequency of activity decreased by 0.18%), and constitutional, cutaneous, and haematological involvements (the frequency decreased by 0.09% for each 1-year increase). In contrast, other domains showed an ascending pattern, especially pulmonary involvement (for each 1-year increase in the age at diagnosis, the frequency of activity increased by 0.22%), and peripheral nerve involvement (the frequency increased by 0.09% for each 1-year increase).Conclusion. The influence of the age at diagnosis on the key phenotypic features of pSS is strong, and should be considered critical not only for designing a personalised diagnostic approach, but also to be carefully considered when analysing the results of diagnostic tests and immunological parameters, and when internal organ involvement is suspected at diagnosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Sjogren's syndrome
- age
- disease phenotype
- immunological markers
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Retamozo, S.
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Acar-Denizli, N.
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Horvath, I. F.
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Ng, W-F
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Rasmussen, A.
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Dong, X.
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show more...
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Li, X.
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Baldini, C.
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Olsson, P.
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Priori, R.
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Seror, R.
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Gottenberg, J-E
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Kruize, A. A.
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Hernandez-Molina ...
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Vissink, A.
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Sandhya, P.
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Armagan, B.
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Quartuccio, L.
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Sebastian, A.
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Praprotnik, S.
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Bartoloni, E.
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Kwok, S-K
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Kvarnstrom, M.
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Rischmueller, M.
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Solans-Laque, R.
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Sene, D.
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Pasoto, S. G.
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Suzuki, Y.
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Isenberg, D. A.
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Valim, V.
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Nordmark, Gunnel
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Nakamura, H.
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Fernandes Moca T ...
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Hofauer, B.
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Siso-Almirall, A ...
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Giacomelli, R.
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Devauchelle-Pens ...
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Bombardieri, M.
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Atzeni, F.
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Hammenfors, D.
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Maure, B.
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Carsons, S. E.
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Gheita, T.
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Sanchez-Berna, I
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Lopez-Dupla, M.
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Morel, J.
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Inanc, N.
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Fonseca-Aizpuru, ...
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Morcillo, C.
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Vollenweider, C.
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Melchor, S.
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Vazquez, M.
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Diaz-Cuiza, E.
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Consani-Fernande ...
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de-Miguel-Campo, ...
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Szanto, A.
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Bombardieri, S.
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Gattamelata, A.
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Hinrichs, A.
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Sanchez-Guerrero ...
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Danda, D.
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Kilic, L.
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de Vita, S.
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Wiland, P.
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Gerli, R.
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Park, S-H
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Wahren-Herlenius ...
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Bootsma, H.
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Mariette, X.
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Ramos-Casals, M.
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Brito-Zeron, P.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Clinical and Exp ...
- By the university
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Uppsala University
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Karolinska Institutet