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  • Ramos-Casals, ManuelInstitutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),Hospital Clínic of Barcelona (författare)

EULAR recommendations for the management of Sjögren's syndrome with topical and systemic therapies.

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2019-10-31
  • BMJ,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-464333
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-464333URI
  • https://doi.org/10.1136/annrheumdis-2019-216114DOI
  • https://lup.lub.lu.se/record/a8258db2-f6e3-4b83-9504-00b1f0ab9dd2URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • The therapeutic management of Sjögren syndrome (SjS) has not changed substantially in recent decades: treatment decisions remain challenging in clinical practice, without a specific therapeutic target beyond the relief of symptoms as the most important goal. In view of this scenario, the European League Against Rheumatism (EULAR) promoted and supported an international collaborative study (EULAR SS Task Force) aimed at developing the first EULAR evidence and consensus-based recommendations for the management of patients with SjS with topical and systemic medications. The aim was to develop a rational therapeutic approach to SjS patients useful for healthcare professionals, physicians undergoing specialist training, medical students, the pharmaceutical industry and drug regulatory organisations following the 2014 EULAR standardised operating procedures. The Task Force (TF) included specialists in rheumatology, internal medicine, oral health, ophthalmology, gynaecology, dermatology and epidemiology, statisticians, general practitioners, nurses and patient representatives from 30 countries of the 5 continents. Evidence was collected from studies including primary SjS patients fulfilling the 2002/2016 criteria; when no evidence was available, evidence from studies including associated SjS or patients fulfilling previous sets of criteria was considered and extrapolated. The TF endorsed the presentation of general principles for the management of patients with SjS as three overarching, general consensus-based recommendations and 12 specific recommendations that form a logical sequence, starting with the management of the central triplet of symptoms (dryness, fatigue and pain) followed by the management of systemic disease. The recommendations address the use of topical oral (saliva substitutes) and ocular (artificial tear drops, topical non-steroidal anti-inflammatory drugs, topical corticosteroids, topical CyA, serum tear drops) therapies, oral muscarinic agonists (pilocarpine, cevimeline), hydroxychloroquine, oral glucocorticoids, synthetic immunosuppressive agents (cyclophosphamide, azathioprine, methotrexate, leflunomide and mycophenolate), and biological therapies (rituximab, abatacept and belimumab). For each recommendation, levels of evidence (mostly modest) and TF agreement (mostly very high) are provided. The 2019 EULAR recommendations are based on the evidence collected in the last 16 years in the management of primary 2002 SjS patients and on discussions between a large and broadly international TF. The recommendations synthesise current thinking on SjS treatment in a set of overarching principles and recommendations. We hope that the current recommendations will be broadly applied in clinical practice and/or serve as a template for national societies to develop local recommendations.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Brito-Zerón, PilarInstitutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),Hospital CIMA (författare)
  • Bombardieri, StefanoUniversity of Pisa (författare)
  • Bootsma, HendrikaUniversity of Groningen (författare)
  • De Vita, SalvatoreUniversity Hospital 'Santa Maria della Misericordia' (författare)
  • Dörner, ThomasCharité - University Medicine Berlin (författare)
  • Fisher, Benjamin AUniversity of Birmingham,University Hospitals Birmingham (författare)
  • Gottenberg, Jacques-EricUniversity of Strasbourg,University Hospital Of Strasbourg (författare)
  • Hernandez-Molina, GabrielaSalvador Zubirán National Institute of Health Sciences and Nutrition (författare)
  • Kocher, AgnesUniversity of Bern,Bern University Hospital (författare)
  • Kostov, BelchinPolytechnic University of Catalonia,Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS) (författare)
  • Kruize, Aike AUniversity Medical Center Utrecht (författare)
  • Mandl, ThomasLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-tma (författare)
  • Ng, Wan-FaiNIHR Newcastle Biomedical Research Centre,University of Newcastle upon Tyne (författare)
  • Retamozo, SoledadNational University of Cordoba, Argentina,Instituto Universitario de Ciencias Biomédicas de Córdoba (författare)
  • Seror, RaphaèleBicêtre Hospital,Assistance Publique des Hôpitaux de Paris (författare)
  • Shoenfeld, YehudaSheba Medical Center,Saint Petersburg State University (författare)
  • Sisó-Almirall, AntoniInstitutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),El Consorci d’Atenció Primària de Salut Barcelona Esquerra (författare)
  • Tzioufas, Athanasios GNational and Kapodistrian University of Athens (författare)
  • Vitali, ClaudioVilla San Giuseppe Santo Stefano Riabilitazione, Como (författare)
  • Bowman, SimonUniversity Hospitals Birmingham (författare)
  • Mariette, XavierBicêtre Hospital,University of Paris-Saclay,Assistance Publique des Hôpitaux de Paris (författare)
  • Nordmark, GunnelUppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)gunnnord (bidragsgivare)
  • Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)Hospital Clínic of Barcelona (creator_code:org_t)
  • EULAR-Sjögren Syndrome Task Force Group

Sammanhörande titlar

  • Ingår i:Annals of the Rheumatic Diseases: BMJ79:1, s. 3-180003-49671468-2060

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