Search: id:"swepub:oai:DiVA.org:uu-464448" >
Plasma Proteome Fin...
-
Bauer, WolfgangCharite Univ Med Berlin, Dept Emergency Med, Freie Univ Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany.
(author)
Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection
- Article/chapterEnglish2021
Publisher, publication year, extent ...
-
2021-12-07
-
MDPI,2021
-
electronicrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-464448
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-464448URI
-
https://doi.org/10.3390/v13122456DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-307156URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
De två sista författarna delar sistaförfattarskapet
-
QC 20220126
-
Background: We evaluated how plasma proteomic signatures in patients with suspected COVID-19 can unravel the pathophysiology, and determine kinetics and clinical outcome of the infection.Methods: Plasma samples from patients presenting to the emergency department (ED) with symptoms of COVID-19 were stratified into: (1) patients with suspected COVID-19 that was not confirmed (n = 44); (2) non-hospitalized patients with confirmed COVID-19 (n = 44); (3) hospitalized patients with confirmed COVID-19 (n = 53) with variable outcome; and (4) patients presenting to the ED with minor diseases unrelated to SARS-CoV-2 infection (n = 20). Besides standard of care diagnostics, 177 circulating proteins related to inflammation and cardiovascular disease were analyzed using proximity extension assay (PEA, Olink) technology.Results: Comparative proteome analysis revealed 14 distinct proteins as highly associated with SARS-CoV-2 infection and 12 proteins with subsequent hospitalization (p < 0.001). ADM, IL-6, MCP-3, TRAIL-R2, and PD-L1 were each predictive for death (AUROC curve 0.80-0.87). The consistent increase of these markers, from hospital admission to intensive care and fatality, supported the concept that these proteins are of major clinical relevance.Conclusions: We identified distinct plasma proteins linked to the presence and course of COVID-19. These plasma proteomic findings may translate to a protein fingerprint, helping to assist clinical management decisions.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Weber, MarcusZuse Inst Berlin ZIB, Takustr 7, D-14195 Berlin, Germany.
(author)
-
Diehl-Wiesenecker, EvaCharite Univ Med Berlin, Dept Emergency Med, Freie Univ Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany.
(author)
-
Galtung, NoaCharite Univ Med Berlin, Dept Emergency Med, Freie Univ Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany.
(author)
-
Prpic, MonikaFree Univ Berlin, Charite Univ Med Berlin, Inst Lab Med Clin Chem & Pathobiochem, Augustenburger Pl 1, D-13353 Berlin, Germany.
(author)
-
Somasundaram, RajanCharite Univ Med Berlin, Dept Emergency Med, Freie Univ Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany.
(author)
-
Tauber, RudolfFree Univ Berlin, Charite Univ Med Berlin, Inst Lab Med Clin Chem & Pathobiochem, Augustenburger Pl 1, D-13353 Berlin, Germany.;Labor Berlin Charite Vivantes GmbH, D-13353 Berlin, Germany.
(author)
-
Schwenk, Jochen M.KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Tomtebodavagen 23, S-17165 Solna, Sweden.(Swepub:kth)u1h7wtme
(author)
-
Micke, PatrickUppsala universitet,Klinisk och experimentell patologi,Patrick Micke,Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjolds Vag 20, S-75185 Uppsala, Sweden.(Swepub:uu)patmi676
(author)
-
Kappert, KaiFree Univ Berlin, Charite Univ Med Berlin, Inst Lab Med Clin Chem & Pathobiochem, Augustenburger Pl 1, D-13353 Berlin, Germany.;Labor Berlin Charite Vivantes GmbH, D-13353 Berlin, Germany.
(author)
-
Charite Univ Med Berlin, Dept Emergency Med, Freie Univ Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany.Zuse Inst Berlin ZIB, Takustr 7, D-14195 Berlin, Germany.
(creator_code:org_t)
Related titles
-
In:Viruses: MDPI13:121999-4915
Internet link
Find in a library
-
Viruses
(Search for host publication in LIBRIS)
To the university's database