SwePub
Sök i LIBRIS databas

  Extended search

id:"swepub:oai:DiVA.org:uu-464448"
 

Search: id:"swepub:oai:DiVA.org:uu-464448" > Plasma Proteome Fin...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Bauer, WolfgangCharite Univ Med Berlin, Dept Emergency Med, Freie Univ Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany. (author)

Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-12-07
  • MDPI,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-464448
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-464448URI
  • https://doi.org/10.3390/v13122456DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-307156URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • De två sista författarna delar sistaförfattarskapet
  • QC 20220126
  • Background: We evaluated how plasma proteomic signatures in patients with suspected COVID-19 can unravel the pathophysiology, and determine kinetics and clinical outcome of the infection.Methods: Plasma samples from patients presenting to the emergency department (ED) with symptoms of COVID-19 were stratified into: (1) patients with suspected COVID-19 that was not confirmed (n = 44); (2) non-hospitalized patients with confirmed COVID-19 (n = 44); (3) hospitalized patients with confirmed COVID-19 (n = 53) with variable outcome; and (4) patients presenting to the ED with minor diseases unrelated to SARS-CoV-2 infection (n = 20). Besides standard of care diagnostics, 177 circulating proteins related to inflammation and cardiovascular disease were analyzed using proximity extension assay (PEA, Olink) technology.Results: Comparative proteome analysis revealed 14 distinct proteins as highly associated with SARS-CoV-2 infection and 12 proteins with subsequent hospitalization (p < 0.001). ADM, IL-6, MCP-3, TRAIL-R2, and PD-L1 were each predictive for death (AUROC curve 0.80-0.87). The consistent increase of these markers, from hospital admission to intensive care and fatality, supported the concept that these proteins are of major clinical relevance.Conclusions: We identified distinct plasma proteins linked to the presence and course of COVID-19. These plasma proteomic findings may translate to a protein fingerprint, helping to assist clinical management decisions.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Weber, MarcusZuse Inst Berlin ZIB, Takustr 7, D-14195 Berlin, Germany. (author)
  • Diehl-Wiesenecker, EvaCharite Univ Med Berlin, Dept Emergency Med, Freie Univ Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany. (author)
  • Galtung, NoaCharite Univ Med Berlin, Dept Emergency Med, Freie Univ Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany. (author)
  • Prpic, MonikaFree Univ Berlin, Charite Univ Med Berlin, Inst Lab Med Clin Chem & Pathobiochem, Augustenburger Pl 1, D-13353 Berlin, Germany. (author)
  • Somasundaram, RajanCharite Univ Med Berlin, Dept Emergency Med, Freie Univ Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany. (author)
  • Tauber, RudolfFree Univ Berlin, Charite Univ Med Berlin, Inst Lab Med Clin Chem & Pathobiochem, Augustenburger Pl 1, D-13353 Berlin, Germany.;Labor Berlin Charite Vivantes GmbH, D-13353 Berlin, Germany. (author)
  • Schwenk, Jochen M.KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Tomtebodavagen 23, S-17165 Solna, Sweden.(Swepub:kth)u1h7wtme (author)
  • Micke, PatrickUppsala universitet,Klinisk och experimentell patologi,Patrick Micke,Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjolds Vag 20, S-75185 Uppsala, Sweden.(Swepub:uu)patmi676 (author)
  • Kappert, KaiFree Univ Berlin, Charite Univ Med Berlin, Inst Lab Med Clin Chem & Pathobiochem, Augustenburger Pl 1, D-13353 Berlin, Germany.;Labor Berlin Charite Vivantes GmbH, D-13353 Berlin, Germany. (author)
  • Charite Univ Med Berlin, Dept Emergency Med, Freie Univ Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany.Zuse Inst Berlin ZIB, Takustr 7, D-14195 Berlin, Germany. (creator_code:org_t)

Related titles

  • In:Viruses: MDPI13:121999-4915

Internet link

Find in a library

  • Viruses (Search for host publication in LIBRIS)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view