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  • Gauffin, HelenaLinköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping (author)

Similar Profile and Magnitude of Cognitive Impairments in Focal and Generalized Epilepsy : A Pilot Study

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-01-12
  • Lausanne, Switzerland :Frontiers Media S.A.2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-464636
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-464636URI
  • https://doi.org/10.3389/fneur.2021.746381DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-182764URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148616454URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding: Funding was received (ALF) from the County Council of Östergötland
  • Introduction: Cognitive impairments in epilepsy are not well-understood. In addition, long-term emotional, interpersonal, and social consequences of the underlying disturbances are important to evaluate.Purpose: To compare cognitive function including language in young adults with focal or generalized epilepsy. In addition, quality of life and self-esteem were investigated.Patients and Methods: Young adults with no primary intellectual disability, 17 with focal epilepsy and 11 with generalized epilepsy participated and were compared to 28 healthy controls. Groups were matched on age (mean = 26 years), sex, and education. Participants were administered a battery of neuropsychological tasks and carried out self-ratings of quality of life, self-esteem, and psychological problems.Results: Similar impairments regarding cognitive function were noted in focal and generalized epilepsy. The cognitive domains tested were episodic long-term memory, executive functions, attention, working memory, visuospatial functions, and language. Both epilepsy groups had lower results compared to controls (effect sizes 0.24-1.07). The total number of convulsive seizures was predictive of episodic long-term memory function. Participants with focal epilepsy reported lower quality of life than participants with generalized epilepsy. Lowered self-esteem values were seen in both epilepsy groups and particularly in those with focal epilepsy. Along with measures of cognitive speed and depression, the total number of seizures explained more than 50% of variation in quality of life.Conclusion: Interestingly, similarities rather than differences characterized the widespread cognitive deficits that were seen in focal and generalized epilepsy, ranging from mild to moderate. These similarities were modified by quality of life and self-esteem. This study confirms the notion that epilepsy is a network disorder.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Landtblom, Anne-MarieLinköpings universitet,Uppsala universitet,Landtblom: Neurovetenskap,Department of Neurology, Faculty of Medicine and Health Sciences Linköping University, Linköping, Sweden.;Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences Linköping University, Linköping, Sweden.;Neurology Division, Clinic of Medical Specialist, Motala General Hospital, Motala, Sweden;Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden.,Avdelningen för neurobiologi,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Neurologiska kliniken i Linköping,Region Östergötland, Medicinska specialistkliniken,Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden;(Swepub:liu)annla55 (author)
  • Vigren, PatrickLinköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping(Swepub:liu)patvi83 (author)
  • Frick, Andreas,DocentUppsala universitet,Cervenka: Psykiatri,The Beijer Laboratory, Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden(Swepub:uu)andfr548 (author)
  • Engström, MariaLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)maren21 (author)
  • McAllister, AnitaKarolinska Institutet (author)
  • Karlsson, ThomasLinköpings universitet,Uppsala universitet,Landtblom: Neurovetenskap,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden(Swepub:liu)thoka00 (author)
  • Linköpings universitetAvdelningen för neurobiologi (creator_code:org_t)

Related titles

  • In:Frontiers in NeurologyLausanne, Switzerland : Frontiers Media S.A.121664-2295

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