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  • Ayhan, NazliAix Marseille Univ, Unite Virus Emergents, IRD 190, Inserm 1207,IHU Mediterranee Infect, Marseille, France. (författare)

Field surveys in Croatia and North Macedonia reveal two novel phleboviruses circulating in sandflies

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Microbiology Society,2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-466914
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-466914URI
  • https://doi.org/10.1099/jgv.0.001674DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Sandfly-borne phleboviruses are distributed widely throughout the Mediterranean Basin, presenting a threat to public health in areas where they circulate. However, the true diversity and distribution of pathogenic and apathogenic sandfly-borne phleboviruses remains a key issue to be studied. In the Balkans, most published data rely on serology-based studies although virus isolation has occasionally been reported. Here, we report the discovery of two novel sandfly-borne phleboviruses, provisionally named Zaba virus (ZABAV) and Bregalaka virus (BREV), which were isolated in Croatia and North Macedonia, respectively. This constitutes the first isolation of phleboviruses in both countries. Genetic analysis based on complete coding sequences indicated that ZABAV and BREV are distinct from each other and belong to the genus Phlebovirus, family Phenuiviridae. Phylogenetic and amino acid modelling of viral polymerase shows that ZABAV and BREV are new members of the Salehabad phlebovirus species and the Adana phlebovirus species, respectively. Moreover, sequence-based vector identification suggests that ZABAV is mainly transmitted by Phlebotomus neglectus and BREV is mainly transmitted by Phlebotomus perfiliewi. BREV neutralizing antibodies were detected in 3.3% of human sera with rates up to 16.7% in certain districts, demonstrating that BREV frequently infects humans in North Macedonia. In vitro viral growth kinetics experiments demonstrated viral replication of both viruses in mammalian and mosquito cells. In vivo experimental studies in mice suggest that ZABAV and BREV exhibit characteristics making them possible human pathogens.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Alten, BulentHacettepe Univ, Fac Sci, Dept Biol, Ecol Div,VERG Labs, Ankara, Turkey. (författare)
  • Ivovic, VladimirUniv Primorska, Fac Math Nat Sci & Informat Technol FAMNIT, Koper, Slovenia. (författare)
  • Cvetkovikj, AleksandarSs Cyril & Methodius Univ Skopje, Fac Vet Med, Dept Parasitol & Parasit Dis, Lazar Pop Trajkov 5-7, Skopje 1000, North Macedonia. (författare)
  • Stefanovska, JovanaSs Cyril & Methodius Univ Skopje, Fac Vet Med, Dept Parasitol & Parasit Dis, Lazar Pop Trajkov 5-7, Skopje 1000, North Macedonia. (författare)
  • Martinkovic, FranjoUniv Zagreb, Fac Vet Med, Dept Parasitol & Parasit Dis Clin, Zagreb, Croatia. (författare)
  • Piorkowski, GeraldineAix Marseille Univ, Unite Virus Emergents, IRD 190, Inserm 1207,IHU Mediterranee Infect, Marseille, France. (författare)
  • Moureau, GregoryAix Marseille Univ, Unite Virus Emergents, IRD 190, Inserm 1207,IHU Mediterranee Infect, Marseille, France. (författare)
  • Gould, Ernest A.Aix Marseille Univ, Unite Virus Emergents, IRD 190, Inserm 1207,IHU Mediterranee Infect, Marseille, France. (författare)
  • Pettersson, John,1981-Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala Univ, Zoonosis Sci Ctr, Dept Med Biochem & Microbiol IMBIM, Uppsala, Sweden.;Univ Sydney, Charles Perkins Ctr, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia.;Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia.(Swepub:uu)johpe964 (författare)
  • de Lamballerie, XavierAix Marseille Univ, Unite Virus Emergents, IRD 190, Inserm 1207,IHU Mediterranee Infect, Marseille, France. (författare)
  • Charrel, Remi N.Aix Marseille Univ, Unite Virus Emergents, IRD 190, Inserm 1207,IHU Mediterranee Infect, Marseille, France. (författare)
  • Aix Marseille Univ, Unite Virus Emergents, IRD 190, Inserm 1207,IHU Mediterranee Infect, Marseille, France.Hacettepe Univ, Fac Sci, Dept Biol, Ecol Div,VERG Labs, Ankara, Turkey. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of General Virology: Microbiology Society102:110022-13171465-2099

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