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Failure to restore ...
Failure to restore CD4(+) cell count associated with infection-related and noninfection-related cancer
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- Malmstrom, Stina (författare)
- Vastmanland Cty Hosp Västerås, Dept Infect Dis, Västerås, Sweden.;Uppsala Univ, Vastmanland Cty Hosp, Ctr Clin Res Vastmanland, Västerås, Sweden.
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- Wagner, Philippe (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås
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- Yilmaz, Aylin, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Svedhem, Veronica (författare)
- Karolinska Institutet
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- Carlander, Christina (författare)
- Karolinska Institutet
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Vastmanland Cty Hosp Västerås, Dept Infect Dis, Västerås, Sweden;Uppsala Univ, Vastmanland Cty Hosp, Ctr Clin Res Vastmanland, Västerås, Sweden. Centrum för klinisk forskning, Västerås (creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2022
- 2022
- Engelska.
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Ingår i: AIDS. - : Ovid Technologies (Wolters Kluwer Health). - 0269-9370 .- 1473-5571. ; 36:3, s. 447-457
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Objective: To assess incidence and relative risk of cancer in Sweden, by HIV status, from 1988 to 2017. Design: Population-based register study. Methods: From the Swedish Total Population Register, all people born between 1940 and 2000 (n = 8 587 629), and resident in Sweden sometime 1983-2017 were identified and linked to National HIV Register InfCareHIV, National Cancer Register, and LISA database. We present incidence and adjusted hazard ratios (adjHR) of infection and noninfection-related cancer for three periods between 1988 and 2017. Results: Incidence and relative risk of infection-related cancer decreased but remained higher in people with HIV (PWH) than in HIV-negative. The proportion attributable to infection remained higher in PWH than in HIV-negative (44 vs. 9%). Women with HIV had lower risk of infection-related cancer than men with HIV [adjusted hazard ratio (adjHR) 0.6, 95% CI 0.4-0.9], mainly driven by lower incidence of Kaposi's sarcoma (adjHR 0.1, 95% CI 0.0-0.4). Current viral suppression (adjHR 0.3, 95% CI 0.2-0.5) was associated with lower risk of infection-related cancer. Current CD4(+) cell count less than 200 cells/mu l was associated with both infection-related (adjHR 15.3, 95% CI 10.7-21.8) and noninfection-related cancer (adjHR 2.5, 95% CI 1.5-4.1), as was CD4(+) cell count increases less than 100 cells/mu l post antiretroviral therapy (ART) (infection-related cancer adjHR 6.6, 95% CI 4.2-10.6, noninfection-related cancer adjHR 2.0, 95% CI 1.2-3.3). Conclusion: Current CD4(+) cell count and failure to restore CD4(+) cell count both associated with infection and noninfection-related cancer. Viral suppression associated with lower risk of infection-related cancer. Early HIV detection and early adherent ART remain essential for cancer prevention.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- antiretroviral therapy
- cancer
- HIV
- incidence rates
- women
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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